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MBD2 Antibody (4D4D5)

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Western Blot: MBD2 Antibody (4D4D5) [NBP3-16317] - Western blot analysis of extracts of Mouse liver cells, using MBD2 antibody (NBP3-16317) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at ...read more

Product Details

Summary
Reactivity MuSpecies Glossary
Applications WB
Clone
4D4D5
Clonality
Monoclonal
Host
Rabbit
Conjugate
Unconjugated

Order Details

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MBD2 Antibody (4D4D5) Summary

Additional Information
Recombinant Monoclonal Antibody
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 100-200 of human MBD2 (Q9UBB5). GGSGLGGDGGGCGGGGSGGGGAPRREPVPFPSGSAGPGPRGPRATESGKRMDCPALPPGWKKEEVIRKSGLSAGKSDVYYFSPSGKKFRSKPQLARYLGNT
Isotype
IgG
Clonality
Monoclonal
Host
Rabbit
Gene
MBD2
Purity
Affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:500 - 1:1000

Packaging, Storage & Formulations

Storage
Store at -20C. Avoid freeze-thaw cycles.
Buffer
PBS, 0.05% BSA, 50% glycerol, pH7.3
Preservative
0.02% Sodium Azide
Purity
Affinity purified

Alternate Names for MBD2 Antibody (4D4D5)

  • Demethylase
  • DKFZp586O0821
  • DMTase
  • MBD2
  • methyl-CpG binding domain protein 2
  • methyl-CpG-binding domain protein 2
  • Methyl-CpG-binding protein MBD2
  • NY-CO-41

Background

DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. The protein encoded by this gene may function as a mediator of the biological consequences of the methylation signal. It is also reported that the this protein functions as a demethylase to activate transcription, as DNA methylation causes gene silencing. [provided by RefSeq]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol

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Secondary Antibodies

 

Isotype Controls

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Array NBP3-16317

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Bioinformatics

Gene Symbol MBD2