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Matriptase 2 Antibody

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Western Blot: Matriptase 2 Antibody [NBP1-57098] - Titration: 0.2-1 ug/ml, Positive Control: Jurkat cell lysate.
Western Blot: Matriptase 2 Antibody [NBP1-57098] - Titration: 0.2-1 ug/ml, Positive Control: Jurkat cell lysate.
Immunohistochemistry-Paraffin: Matriptase 2 Antibody [NBP1-57098] - Human Liver tissue, 5 ug/ml.

Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, IHC
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
0.5 mg/ml

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Matriptase 2 Antibody Summary

Description
The addition of 50% glycerol is optional for those storing this antibody at -20C and not aliquoting smaller units. However, please note that glycerol may interrupt some downstream antibody applications and should be added with caution.
Immunogen
Synthetic peptides corresponding to TMPRSS6(transmembrane protease, serine 6) The peptide sequence was selected from the N terminal of TMPRSS6. Peptide sequence LLWYFLGYKAEVMVSQVYSGSLRVLNRHFSQDLTRRESSAFRSETAKAQK. The peptide sequence for this immunogen was taken from within the described region.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
TMPRSS6
Purity
Affinity purified
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Applications/Dilutions

Dilutions
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 1:10-1:500
  • Western Blot 1.0 ug/ml

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS, 2% Sucrose
Preservative
0.09% Sodium Azide
Concentration
0.5 mg/ml
Purity
Affinity purified

Alternate Names for Matriptase 2 Antibody

  • EC 3.4.21
  • EC 3.4.21.-
  • FLJ30744
  • IRIDA
  • Matriptase-2
  • membrane-bound mosaic serine proteinase matriptase-2
  • transmembrane protease serine 6
  • transmembrane protease, serine 6
  • type II transmembrane serine protease 6

Background

TMPRSS6 is a serine protease which hydrolyzes a range of proteins including type I collagen, fibronectin and fibrinogen. TMPRSS6 can also activate urokinase-type plasminogen activator with low efficiency. TMPRSS6 may play a specialized role in matrix remodeling processes in liver. TMPRSS6 is required to sense iron deficiency. Overexpression of TMPRSS6 suppresses activation of the HAMP promoter.The protein encoded by this gene is a type II transmembrane serine proteinase that is found attached to the cell surface. The encoded protein may be involved in matrix remodeling processes in the liver.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Matriptase 2 Antibody
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Bioinformatics

Gene Symbol TMPRSS6
Uniprot