Lysyl Oxidase Homolog 2/LOXL2 Antibody (262418)

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Lysyl Oxidase Homolog 2 (lysyl oxidase-like protein 2, LOXL2) is a member of lysyl oxidase-like (LOXL) gene family which includes LOXL1 through LOXL4. These enzymes are secreted copper-binding amine oxidases that oxidize primary amine substrates to aldehydes (1). The N-terminal region of LOXL2 contains four scavenger receptor cysteine-rich (SRCR) domains, and the C-terminal region is a catalytic domain similar to other lysyl oxidases (1). The catalytic domain contains conserved residues required for copper binding and formation of a lysyl tyrosylquinone co-factor (2). Although some of the LOXL enzymes are known to cross-link collagen and elastin substrates, such a function has yet to be characterized for LOXL2. It has been shown that LOXL2 promotes cell migration and tumor cell invasiveness (3, 4). Elevated expression of LOXL2 is also associated with cancer progression in various tumors and carcinoma cell lines, which makes it a potential marker for prognosis of cancer (5). LOXL2 is expressed in many tissues, with elevated levels in reproductive tissues such as placenta, uterus, and prostate (6).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 3 applications: IHC, Immunoprecipitation, Western Blot.

Showing Publications 1 - 4 of 4.

Publications using MAB2639	Applications	Species
S Vukicevic, A Colliva, V Kufner, V Martinelli, S Moimas, S Vodret, V Rumenovic, M Milosevic, B Brkljacic, D Delic-Brkl, R Correa, M Giacca, M Maglione, T Bordukalo-, I Dumic-Cule, S Zacchigna Bone morphogenetic protein 1.3 inhibition decreases scar formation and supports cardiomyocyte survival after myocardial infarction Nature Communications, 2022-01-10;13(1):81. 2022-01-10 [PMID: 35013172] (IHC, Mouse)	IHC	Mouse
Peng T, Deng X, Tian F et al. The interaction of LOXL2 with GATA6 induces VEGFA expression and angiogenesis in cholangiocarcinoma Int. J. Oncol. 7/15/2019 [PMID: 31322171]
Sethi A, Wordinger RJ, Clark AF. Gremlin utilizes canonical and non-canonical TGFbeta signaling to induce lysyl oxidase (LOX) genes in human trabecular meshwork cells. Exp Eye Res. 8/1/2013 [PMID: 23748100]
Peng L, Ran YL, Hu H, Yu L, Liu Q, Zhou Z, Sun YM, Sun LC, Pan J, Sun LX, Zhao P, Yang ZH Secreted LOXL2 is a novel therapeutic target that promotes gastric cancer metastasis via the Src/FAK pathway. Carcinogenesis, 2009-07-22;30(10):1660-9. 2009-07-22 [PMID: 19625348] (Immunoprecipitation, Western Blot, Human)	Immunoprecipitation, Western Blot	Human

Array MAB2639

• Lysyl Oxidase Homolog 2/LOXL2 Antibodies
• Lysyl Oxidase Homolog 2/LOXL2 Antibody Pair
• Lysyl Oxidase Homolog 2/LOXL2 Lysate
• Lysyl Oxidase Homolog 2/LOXL2 Protein
• Lysyl Oxidase Homolog 2/LOXL2 Proteins and Enzymes
• Lysyl Oxidase Homolog 2/LOXL2 ELISA