LRP-6 Antibody (255302) [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

LRP-6 (Low-density lipoprotein receptor-related protein 6) is a 200-210 kDa member of the LDLR family of proteins. It is widely expressed, and serves as a coreceptor for both Wnt and parathyroid hormone. In the Wnt system, LRP-6 associates with select Fzd multipass receptors; in the PTH system, LRP-6 complexes with PTH1R. Mature human LRP-6 is a 1594 amino acid (aa) type I transmembrane glycoprotein. It contains a 1351 aa extracellular region (aa 20-1370) plus a 220 aa cytoplasmic domain (aa 1394-1613). The cytoplasmic domain contains two palmitoylation sites, one ubiquitination residue, and multiple phosphorylation motifs.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: Flow Cytometry.

Showing Publications 1 - 6 of 6.

Publications using MAB1505	Applications	Species
Alice Yu, Yuanyuan Li, Irene Li, Michael G. Ozawa, Christine Yeh, Aaron E. Chiou et al. Reconstructing codependent cellular cross-talk in lung adenocarcinoma using REMI Science Advances 3/18/2022 [PMID: 35302849]
George T. Chen, Delia F. Tifrea, Rabi Murad, Amber N. Habowski, Yung Lyou, Madeleine R. Duong et al. Disruption of beta-catenin dependent Wnt signaling in colon cancer cells remodels the microenvironment to promote tumor invasion Molecular Cancer Research 3/1/2022 [PMID: 34799404]
Megan J. Agajanian, Matthew P. Walker, Alison D. Axtman, Roberta R. Ruela-de-Sousa, D. Stephen Serafin, Alex D. Rabinowitz et al. WNT Activates the AAK1 Kinase to Promote Clathrin-Mediated Endocytosis of LRP6 and Establish a Negative Feedback Loop Cell Reports 1/2/2019 [PMID: 30605688]
BS Berger, SP Acebron, J Herbst, S Koch, C Niehrs Parkinson's disease-associated receptor GPR37 is an ER chaperone for LRP6 EMBO Rep, 2017-03-24;0(0):. 3/24/2017 [PMID: 28341812]
USP6 oncogene promotes Wnt signaling by deubiquitylating Frizzleds Proc Natl Acad Sci USA, 2016-05-09;113(21):E2945-54. 2016-05-09 [PMID: 27162353] (Flow Cytometry, Human)	Flow Cytometry	Human
Hao HX, Xie Y, Zhang Y, Charlat O, Oster E, Avello M, Lei H, Mickanin C, Liu D, Ruffner H, Mao X, Ma Q, Zamponi R, Bouwmeester T, Finan PM, Kirschner MW, Porter JA, Serluca FC, Cong F ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner. Nature, 2012-04-29;485(7397):195-200. 2012-04-29 [PMID: 22575959] (Flow Cytometry, Human)	Flow Cytometry	Human

Array MAB1505

• LRP-6 Antibodies
• LRP-6 ELISA Kit
• LRP-6 Lysate
• LRP-6 Proteins and Enzymes