LRP-6 Products

Description

Please note, this product is one of a range of Investigative Grade antibodies, made against targets that have limited or no commercial antibodies available to them and for which there are no data on the expression of the protein in the range of common cell lines and tissues available to us. These antibodies are affinity purified using their peptide immunogen and are known to give low background staining in a western blot (see Application Notes below). However no additional claims are made for their ability to recognise native protein in any application. LRP6 is essential for the Wnt/beta catenin signaling pathway, probably by acting as a coreceptor together with Frizzled for Wnt. It is a specific, high-affinity receptor for DKK1 and DKK2, but not DKK3. The interaction with DKK1 blocks LRP6-mediated Wnt/beta catenin signaling via LRP6 removal via Kremen proteins-mediated endocytosis.

Bioinformatics

Entrez	16974 Mouse 4040 Human
Uniprot	NM_002336 Human NP_002327 Human O75581 Human
Product By Gene ID	4040
Alternate Names	ADCAD2 FLJ90062 FLJ90421 low density lipoprotein receptor-related protein 6 low-density lipoprotein receptor-related protein 6 LRP-6

Research Areas for LRP-6

Find related products by research area and learn more about each of the different research areas below.

Phospho-Specific
Stem Cell Signaling Pathway