LLGL2 Antibody (4G2)

This product is produced by and distributed for Abnova, a company based in Taiwan.

The lethal (2) giant larvae protein of Drosophila plays a role in asymmetric cell division, epithelial cell polarity, and cell migration. This human gene encodes a protein similar to lethal (2) giant larvae of Drosophila. In fly, the protein's ability to localize cell fate determinants is regulated by the atypical protein kinase C (aPKC). In human, this protein interacts with aPKC-containing complexes and is cortically localized in mitotic cells. Alternative splicing results in multiple transcript variants encoding different isoforms.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: IHC-P.

Showing Publications 1 - 8 of 8.

Publications using H00003993-M06	Applications	Species
Dong W, Zhang X, Liu W et al. A conserved polybasic domain mediates plasma membrane targeting of Lgl and its regulation by hypoxia. J Cell Biol. 2015-10-26 [PMID: 26483556]
Patil DT, Bennett AE, Mahajan D, Bronner MP. Distinguishing Barrett gastric foveolar dysplasia from reactive cardiac mucosa in gastroesophageal reflux disease. Hum Pathol. 2013-01-17 [PMID: 23332925]
Russ A, Louderbough JM, Zarnescu D, Schroeder JA. Hugl1 and Hugl2 in mammary epithelial cells: polarity, proliferation, and differentiation. PLoS One. 2012-01-01 [PMID: 23110097] (Human)		Human
Norman M, Wisniewska KA, Lawrenson K et al. Loss of Scribble causes cell competition in mammalian cells. J Cell Sci. 2012-01-16 [PMID: 22250205]
Tamori Y, Bialucha CU, Tian AG et al. Involvement of Lgl and Mahjong/VprBP in cell competition. PLoS Biol. 2010-07-13 [PMID: 20644714]
Cong W, Hirose T, Harita Y et al. ASPP2 Regulates Epithelial Cell Polarity through the PAR Complex. Curr Biol. 2010-07-07 [PMID: 20619648]
Lisovsky M, Dresser K, Baker S et al. Cell polarity protein Lgl2 is lost or aberrantly localized in gastric dysplasia and adenocarcinoma: an immunohistochemical study. Mod Pathol 2009-07-01 [PMID: 19407852] (IHC-P, Human)	IHC-P	Human
Halbert D, Domenyuk V, Spetzler D et al. Aptamers and uses thereof United States Patent Application US 9958448 B2 2018-01-01

Array H00003993-M06

• LLGL2 Antibodies
• LLGL2 Protein