Livin Antibody

Livin (BIRC7/KIAP) is a member of the family of inhibitor of apoptosis proteins (IAP) and contains a single copy of a baculovirus IAP repeat (BIR) as well as a RING-type zinc finger domain (reviewed in Ma et al 2006 and Crnkovic-Mertens et al 2006). Resistance towards apoptosis is a hallmark of cancer cells, and overexpression of IAPs can contribute to the development of cancer though inhibiting apoptosis (reviewed in Wright et al. 2005). IAP proteins inhibit apoptosis by binding to and inhibiting caspases through their BIR domain(s). Some IAP members, like Liven, also have a RING-type finger motif at their carboxyl-terminal which may enhance anti-apoptotic activity. Many RING finger-containing IAPs possess E3 ubiquitin ligase activity, and it has been shown that Liven acts an E3 ubiquitin ligase for targeting the degradation of Smac/DIABLO. Smac/DIABLO functions by inhibiting IAP-caspase interactions, thereby promoting apoptosis. Thus, degradation of Smac/DIABLO is thought to be a mechanism to enhance Livin anti-apoptotic activity, thereby promoting cell survival. Two splicing variants of Livin, alpha and beta, have been identified. The two isoforms are thought to have different anti-apoptotic properties; however, there are conflicting reports are to whether they actually differ in their biological activities. There is accumulating evidence that Liven plays a significant role in a spectrum of tumor types and it is thought that Liven may have potential as a diagnostic and prognostic tumor marker. Liven is expressed at low levels in adult tissues, and relatively higher levels in developmental tissues and in many cancer cells. Certain cancer patients develop autoantibodies against liven and in a number of cancers, Livin is detected only in the tumors but not, or to substantially lower levels, in the corresponding normal adjacent tissue. This antibody recognizes Livin, both isoform alpha and isoform beta. Human Livin isoform alpha is a 298 amino acid (aa) protein, GenBank no. NP_647478. Human Livin isoform beta is a 280 aa protein, GenBank no. NP_071444.1. The antibody will also recognize other isoforms of Livin that contain the peptide immunogen sequence.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 3 applications: IHC-P, WB, Western Blot.

Showing Publications 1 - 6 of 6.

Publications using NB100-56145	Applications	Species
Ye Z, Pan J, Yin Z et al. Dendritic cells infected with recombinant adenoviral vector encoding mouse fibroblast activation protein-? and human livin ? exert an antitumor effect against Lewis lung carcinoma in mice Immun Inflamm Dis 2023-09-27 [PMID: 37773704] (Western Blot)	Western Blot
Altieri B, Sbiera S, Della Casa S et al. Livin/BIRC7 expression as malignancy marker in adrenocortical tumors Oncotarget 2016-12-21 [PMID: 28030838] (IHC-P, WB, Human)	IHC-P, WB	Human
Wang J, Zhang X, Wei P et al. Livin, Survivin and Caspase 3 as early recurrence markers in non-muscle-invasive bladder cancer. World J Urol 2014-03-05 [PMID: 24595485] (IHC-P, Human) Details: Normal bladder and non-muscle-invasive bladder cancer, Figs 1a-b, 2, Tables 1-3	IHC-P	Human
Dai CH, Li J, Shi SB et al. Survivin and Smac gene expressions but not livin are predictors of prognosis in non-small cell lung cancer patients treated with adjuvant chemotherapy following surgery. Jpn J Clin Oncol. 2010-04-01 [PMID: 20056675] (IHC-P, Human) Details: IHC (P): Human non-small lung cancer, Figs 1 and 5; Table 1.	IHC-P	Human
Xie J, Xiong L, Tao X et al. Antitumor effects of murine bone marrow-derived dendritic cells infected with xenogeneic livin alpha recombinant adenoviral vectors against Lewis lung carcinoma. Lung Cancer. 2010-06-01 [PMID: 19671483] (WB) Details: WB (Fig 4): Lane 1, mouse dendritic cells infected with human livin alpha adenovirus (Ad) Lane 2, mock-infected mouse dendritic cells (negative control for livin expression) Lane 3, Lewis lung carcinoma mouse (LLC) cell line Note: the specificity of the a	WB
Liu HB, Kong CZ, Zeng Y et al. Livin may serve as a marker for prognosis of bladder cancer relapse and a target of bladder cancer treatment. Urol Oncol. 2009-05-01 [PMID: 18555709] (WB, Human) Details: WB: Fig 1 (human bladder cancer tissues) and Fig 2 (human livin alpha transfected human bladder cell lines, untransfected cell lines were used as a negative control). Note: the specificity of the antibody was validated by WB in human livin alpha transfect	WB	Human

Array NB100-56145

• Livin Antibodies
• Livin ELISA Kit
• Livin Lysates
• Livin Proteins
• Livin Proteins and Enzyme