LDLR Antibody - BSA Free

LDL Receptor (low-density lipoprotein receptor or LDLR) is a key determinant of plasma cholesterol levels and as a ubiquitously expressed cell membrane glycoprotein, it binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells via endocytosis. LDLR is found distributed from plasma membrane to intracellular compartments, cell surface (in the presence of PCSK9) and also localizes to Golgi apparatus as well as early/late endosomes and lysosomes. VLDL, IDL, HDL, and chylomicron remnant are also recognized by LDLR at neutral pH. Receptor-ligand complexes undergo endocytosis via clathrin-coated pits and coated vehicle dispenses to endosomes with LRP6 and ARH (also known as LDLR adaptor protein), connecting LDLR family protein and the endocytic machinery; thereby, acidic condition activates dissociation of internalized ligands. Released ligand particles further travel to lysosomes wherein the ligand is degraded by enzyme, while the receptors recycle back to cell surface. After internalization, LDL particles trigger reduction in HMGCR expression to suppress cholesterol biosynthesis; enhancement of ACAT activity to reduce toxic free cholesterol, and suppression of LDLR synthesis to reduce LDL uptake via SREBPs. Genetic mutations impairing LDLR function results in a condition with extremely elevated serum LDL levels and early onset atherosclerosis known as familial hypercholesterolemia (FH).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 6 applications: ICC/IF, IF/IHC, Immunohistochemistry-Paraffin, In vitro, Simple Western, WB.

Showing Publications 1 - 10 of 17. Show All 17 Publications. Collapse Publications.

Publications using NBP1-06709	Applications	Species
Hu S, Zhu Y, Zhao X et al. Hepatocytic lipocalin-2 controls HDL metabolism and atherosclerosis via Nedd4-1-SR-BI axis in mice Developmental cell 2023-10-18 [PMID: 37863040] (In vitro, Mouse)	In vitro	Mouse
Thapa K, Kadiri JJ, Saukkonen K et al. Melanocortin 1 receptor regulates cholesterol and bile acid metabolism in the liver eLife 2023-07-25 [PMID: 37490042]
O'Neill KI, Kuo LW, Williams MM et al. NPC1 Confers Metabolic Flexibility in Triple Negative Breast Cancer Cancers 2022-07-21 [PMID: 35884604] (WB, Human)	WB	Human
Ho WY; Chang JC; Lim K et al. TDP-43 mediates SREBF2-regulated gene expression required for oligodendrocyte myelination Journal of Cell Biology 2021-09-06 [PMID: 34347016] (Immunohistochemistry-Paraffin)	Immunohistochemistry-Paraffin
Xu Y, Li Y, Jadhav K, et al. Hepatocyte ATF3 protects against atherosclerosis by regulating HDL and bile acid metabolism Nature metabolism 2021-01-01 [PMID: 33462514]
Kohlhaas J, Jager M. A, et al. Endothelial cells control vascular smooth muscle cell cholesterol levels by regulating 24-dehydrocholesterol reductase expression. Exp Cell Res 2021-01-07 [PMID: 33422461] (Simple Western, Human)	Simple Western	Human
He B, Moreau R R-alpha-Lipoic Acid and 4-Phenylbutyric Acid Have Distinct Hypolipidemic Mechanisms in Hepatic Cells Biomedicines 2020-08-15 [PMID: 32824248] (WB, Human)	WB	Human
Xu Y, Zhu Y, Bawa F et al. HepatocyteSpecific Expression of Human Carboxylesterase 1 Attenuates Diet-Induced Steatohepatitis and Hyperlipidemia in Mice Hepatol Commun 2020-02-20 [PMID: 32258948] (WB, Mouse)	WB	Mouse
Biswas L, Zeng Z, Graham A, Shu X Gypenosides mediate cholesterol efflux and suppress oxidized LDL induced inflammation in retinal pigment epithelium cells Exp. Eye Res. 2020-01-10 [PMID: 31931003] (WB, Human)	WB	Human
Xu J, Xu Y, Xu Y et al. Global inactivation of carboxylesterase 1 (Ces1/Ces1g) protects against atherosclerosis in Ldlr -/- mice. Sci Rep 2017-12-19 [PMID: 29259301] (WB, Mouse)	WB	Mouse
Aldar I, Roy A, ChrEtien M et al. Blockers of PCSK9 Ribosome Synthesis: Computational Predictions and in Vitro Confirmation SSRN Electronic Journal 2022-03-26 (WB, Human)	WB	Human
Sharma B, Gupta V, Dahiya D et al. Clinical relevance of cholesterol homeostasis genes in colorectal cancer Biochim Biophys Acta Mol Cell Biol Lipids 2019-06-13 [PMID: 31202724] (WB, Human)	WB	Human
Yang Yingjie, Yang Qian, Yang Jian et al. Angiotensin II induces cholesterol accumulation and injury in podocytes. Scientific Reports 2017-09-06 [PMID: 28878222] (WB, Human)	WB	Human
Sun L, Yang X et al. Activation of Adiponectin Receptor Regulates Proprotein Convertase Subtilisin/Kexin Type 9 Expression and Inhibits Lesions in ApoE-Deficient Mice. Arterioscler Thromb Vasc Biol 2017-01-07 [PMID: 28546220] (WB, Mouse, Human)	WB	Mouse, Human
Wang M, Gao M, Liao J et al. Adipose tissue deficiency results in severe hyperlipidemia and atherosclerosis in the low-density lipoprotein receptor knockout mice. Biochim. Biophys. Acta. 2016-02-24 [PMID: 26921684] (WB, Mouse)	WB	Mouse
Duan Y, Chen Y, Hu W et al. Peroxisome Proliferator-activated Receptor Activation by Ligands and Dephosphorylation Induces Proprotein Convertase Subtilisin Kexin Type 9 and Low Density Lipoprotein Receptor Expression J Biol Chem 2012-07-06 [PMID: 22593575] (ICC/IF, IF/IHC, WB, Human, Mouse)	ICC/IF, IF/IHC, WB	Human, Mouse
Guo H, Zhang Y, Brockman DA et al. Lipocalin 2 Deficiency Alters Estradiol Production and Estrogen Receptor Signaling in Female Mice. Endocrinology. 2012-01-10 [PMID: 22234464]
Show All 17 Publications. Collapse Publications.

Images	Ratings	Applications	Species	Date	Details
Enlarge	5 reviewed by: Dina Schneider	WB	Mouse	12/08/2016	View Summary Application Western Blot Sample Tested Liver Species Mouse

Array NBP1-06709

• LDLR Antibodies
• LDLR Antibody Pair
• LDLR ELISA Kit
• LDLR Lysate
• LDLR Proteins
• LDLR Proteins and Enzymes
• LDLR ELISAs