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Latent TGF-beta bp1 Antibody (35409) [Unconjugated]

 (11 Publications)
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Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, AP
Clone
35409
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Allophycocyanin
IC388A
View Available Formulations
Catalog# & Formulation Size Price
Carrier Free
IC388A
Carrier Free
MAB388-SP
Carrier Free
MAB388-500
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Latent TGF-beta bp1 Antibody (35409) [Unconjugated] Summary

Immunogen
Human platelet-derived large latent TGF-beta 1 complex
Specificity
Detects human LTBP-1 from the large latent TGF-beta 1 complex.
Source
N/A
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
LTBP1
Purity Statement
Protein A or G purified from ascites
Innovator's Reward
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Applications/Dilutions

Dilutions
  • Immunoaffinity Purification
  • Western Blot 1 ug/mL
Publications
Read Publications using
MAB388 in the following applications:

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Preservative
No Preservative
Reconstitution Instructions
Reconstitute at 0.5 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Latent TGF-beta bp1 Antibody (35409) [Unconjugated]

  • Latent TGFbeta bp1
  • Latent TGF-beta bp1
  • latent transforming growth factor beta binding protein 1
  • latent-transforming growth factor beta-binding protein 1
  • LTBP1
  • LTBP-1
  • MGC163161
  • TGF-beta1-BP-1
  • Transforming growth factor beta-1-binding protein 1

Background

TGF-beta  is synthesized as high molecular weight latent complexes. In platelets, the large latent TGF-beta 1 complex is composed of three components: mature TGF-beta 1 dimer; latency associated peptide; and a latent TGF-beta binding protein (LTBP) (1-3).The cDNAs for four binding proteins (LTBP-1, -2, -3 and -4) have now been cloned (4-5).
  1. Miyazono, K. et al. (1991) EMBO J. 10:1091.
  2. Moren, A. et al. (1994) J. Biol. Chem. 269:32469.
  3. Yin, W. et al. (1995) J. Biol. Chem. 270:10147.
  4. Kanzaki, T. et al. (1990) Cell 61:1051.
  5. Saharinen, J. et al. (1998) J. Biol. Chem. 273:18459.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Latent TGF-beta
bp1 Antibody (35409) ...
MAB388
Latent TGF-beta bp1 Antibody (35409) [Unconjugated]
Species: Hu
Applications: WB, AP

Publications for Latent TGF-beta bp1 Antibody (MAB388)(11)

We have publications tested in 2 confirmed species: Human, Primate - Macaca mulatta (Rhesus Macaque).

We have publications tested in 6 applications: ICC, IHC, IHC-Fr, IHC-P, Immunoprecipitation, Western Blot.


Filter By Application
ICC
(4)
IHC
(1)
IHC-Fr
(1)
IHC-P
(1)
Immunoprecipitation
(1)
Western Blot
(5)
All Applications
Filter By Species
Human
(8)
Primate - Macaca mulatta (Rhesus Macaque)
(1)
All Species
Showing Publications 1 - 10 of 11. Show All 11 Publications.
Publications using MAB388 Applications Species
AJ Alshawaf, S Viventi, W Qiu, G D'Abaco, B Nayagam, M Erlichster, G Chana, I Everall, J Ivanusic, E Skafidas, M Dottori Phenotypic and Functional Characterization of Peripheral Sensory Neurons derived from Human Embryonic Stem Cells Sci Rep, 2018-01-12;8(1):603. 2018-01-12 [PMID: 29330377] (ICC, Human) ICC Human
ATRA modulates mechanical activation of TGF-? by pancreatic stellate cells Sci Rep, 2016-07-04;6(0):27639. 2016-07-04 [PMID: 27375161] (IHC, Human) IHC Human
Franco Klingberg, Melissa L. Chow, Anne Koehler, Stellar Boo, Lara Buscemi, Thomas M. Quinn et al. Prestress in the extracellular matrix sensitizes latent TGF-beta 1 for activation Journal of Cell Biology 10/27/2014 [PMID: 25332161]
Jessica Kast, Patrizia Hanecker, Nathalie Beaufort, Armin Giese, Anne Joutel, Martin Dichgans et al. Sequestration of latent TGF-beta binding protein 1 into CADASIL-related Notch3-ECD deposits Acta Neuropathologica Communications 12/1/2014 [PMID: 25190493]
Brophy T, Coller B, Ahamed J Identification of the thiol isomerase-binding peptide, mastoparan, as a novel inhibitor of shear-induced transforming growth factor beta1 (TGF-beta1) activation. J Biol Chem, 2013-03-05;288(15):10628-39. 2013-03-05 [PMID: 23463512] (Western Blot, Human) Western Blot Human
Willet J, Pichitsiri W, Jenkinson S, Brain J, Wood K, Alhasan A, Spielhofer J, Robertson H, Ali S, Kirby J Kidney transplantation: analysis of the expression and T cell-mediated activation of latent TGF-beta. J Leukoc Biol, 2012-11-27;93(4):471-8. 2012-11-27 [PMID: 23192429] (ICC, IHC-P, Human) ICC, IHC-P Human
Shen M, Siu S, Byrd S, Edelmann KH, Patel N, Ketchem RR, Mehlin C, Arnett HA, Hasegawa H Diverse functions of reactive cysteines facilitate unique biosynthetic processes of aggregate-prone interleukin-31. Exp. Cell Res., 2010-12-21;317(7):976-93. 2010-12-21 [PMID: 21182835] (Western Blot, Human) Western Blot Human
Massam-Wu T, Chiu M, Choudhury R Assembly of fibrillin microfibrils governs extracellular deposition of latent TGF beta. J. Cell. Sci., 2010-08-10;123(0):3006-18. 2010-08-10 [PMID: 20699357] (ICC, Immunoprecipitation, Western Blot, Human) ICC, Immunoprecipitation, Western Blot Human
Vehvilainen P, Hyytiainen M, Keski-Oja J Matrix association of latent TGF-beta binding protein-2 (LTBP-2) is dependent on fibrillin-1. J. Cell. Physiol., 2009-12-01;221(3):586-93. 2009-12-01 [PMID: 19681046] (ICC, Western Blot, Human) ICC, Western Blot Human
Gomez D, Al Haj Zen A, Borges LF, Philippe M, Gutierrez PS, Jondeau G, Michel JB, Vranckx R Syndromic and non-syndromic aneurysms of the human ascending aorta share activation of the Smad2 pathway. J. Pathol., 2009-05-01;218(1):131-42. 2009-05-01 [PMID: 19224541] (IHC-Fr, Human) IHC-Fr Human
Show All 11 Publications.

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Bioinformatics

Gene Symbol LTBP1