Lactate Dehydrogenase B Antibody (2H6)

This product is produced by and distributed for Abnova, a company based in Taiwan.

Lactate dehydrogenase (LDH) is an ubiquitous enzyme commonly found in wide variety of organisms, including plants and microbes. LDH is involved in the interconversion of the pyruvate and NADH to lactate and NAD+. It is also called Hydroxybutyrate Dehydrogenase (HBD), because it can catalyze the oxidation of hydroxybutyrate (1). In mammals, three types of LDH subunits (35 kDa) are encoded by the genes Ldh-A, Ldh-B, and Ldh-C. All LDH subunits can combine to form various terameric isoenzymes (140 kDa). Lactate dehydrogenase B (LDH-B, heart subunit, LDH-H) is involved in the conversion of L-lactate and NAD to pryruvate and NADH and it is predominantly localized in the heart tissue. Similar to other LDH subunit, LDH-B is considered to be an important marker for germ cell tumor (2).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: WB.

Showing Publications 1 - 7 of 7.

Publications using H00003945-M01	Applications	Species
Haruki S, Hisakazu K, Yuki K et al. Aberrant accumulation of TMEM43 accompanied by perturbed transmural gene expression in arrhythmogenic cardiomyopathy. FASEB J. 2021-11-15 [PMID: 34674311]
Catherine Vander Linden, Cyril Corbet, Estelle Bastien, Ruben Martherus, Céline Guilbaud, Laurenne Petit, Loris Wauthier, Axelle Loriot, Charles De Smet, Olivier Feron Therapy-induced DNA methylation inactivates MCT1 and renders tumor cells vulnerable to MCT4 inhibition. Cell reports 2022-02-11 [PMID: 34077729]
Wen-Kuan H, Jiwei G, Ziqing C et al. Heterogeneity of Metabolic Vulnerability in Imatinib -Resistant Gastrointestinal Stromal Tumor. Cells. 2020-05-26 [PMID: 32466502]
Ohkawara H, Ishibashi T, Sugimoto K et al. Membrane Type 1-Matrix Metalloproteinase/Akt Signaling Axis Modulates TNF-alpha-Induced Procoagulant Activity and Apoptosis in Endothelial Cells. PLoS One. 2014-08-27 [PMID: 25162582]
De Saedeleer CJ, Copetti T, Porporato PE et al. Lactate Activates HIF-1 in Oxidative but Not in Warburg-Phenotype Human Tumor Cells PLoS One 2012-01-01 [PMID: 23082126] (WB, Human)	WB	Human
Len AC, Powner MB, Zhu L et al. Pilot application of iTRAQ to the retinal disease Macular Telangiectasia. J Proteome Res. 2012-02-03 [PMID: 22098468] (Human)		Human
Zhang L, Zhang ZP, Zhang XE et al. Quantitative proteomics analysis reveals BAG3 as a potential target to suppress severe acute respiratory syndrome coronavirus replication. J Virol 84(12):6050-9. 2010-06-01 [PMID: 20392858]

Array H00003945-M01

• Lactate Dehydrogenase B Antibodies
• Lactate Dehydrogenase B ELISA Kits
• Lactate Dehydrogenase B Lysate
• Lactate Dehydrogenase B Protein
• Lactate Dehydrogenase B Proteins and Enzyme