KMT3B/NSD1 Antibody (4F1)

This product is produced by and distributed for Abnova, a company based in Taiwan.

This gene encodes a protein containing a SET domain, 2 LXXLL motifs, 3 nuclear translocation signals (NLSs), 4 plant homeodomain (PHD) finger regions, and a proline-rich region. The encoded protein enhances androgen receptor (AR) transactivation, and this enhancement can be increased further in the presence of other androgen receptor associated coregulators. This protein may act as a nucleus-localized, basic transcriptional factor and also as a bifunctional transcriptional regulator. Mutations of this gene have been associated with Sotos syndrome and Weaver syndrome. One version of childhood acute myeloid leukemia is the result of a cryptic translocation with the breakpoints occurring within nuclear receptor-binding Su-var, enhancer of zeste, and trithorax domain protein 1 on chromosome 5 and nucleoporin, 98-kd on chromosome 11. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq]

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: WB.

Showing Publications 1 - 3 of 3.

Publications using H00064324-M08	Applications	Species
Zhang S, Jiang M, Cao H et al. CTB-193M12.5 Promotes Hepatocellular Carcinoma Progression via Enhancing NSD1-Mediated WNT10B/Wnt/beta-Catenin Signaling Activation Journal of hepatocellular carcinoma 2022-06-07 [PMID: 35698644] (WB, Human)	WB	Human
Zhang S, Xu J, Cao H et al. KB-68A7.1 Inhibits Hepatocellular Carcinoma Development Through Binding to NSD1 and Suppressing Wnt/?-Catenin Signalling Frontiers in Oncology 2022-01-20 [PMID: 35127520]
Lu T, Jackson MW, Wang B et al. Regulation of NF-kappaB by NSD1/FBXL11-dependent reversible lysine methylation of p65. Proc Natl Acad Sci U S A 107(1):46-51. 2010-01-05 [PMID: 20080798]

Array H00064324-M08

• KMT3B/NSD1 Antibodies
• KMT3B/NSD1 Proteins