Immunohistochemistry-Paraffin: KiSS1R/GPR54 Antibody [NLS1928] - Anti-KISS1R / GPR54 antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. ...read more
Immunohistochemistry-Paraffin: KiSS1R/GPR54 Antibody [NLS1928] - Analysis of anti-KISS1R / GPR54 antibody with human brain, cerebellum at dilution 3-5 ug/ml.
Predicted cross-reactivity based on sequence identity: Gibbon (95%), Marmoset (80%).
Packaging, Storage & Formulations
Storage
Keep as concentrated solution. Aliquot and store at -20C or below. Avoid multiple freeze-thaw cycles.
Buffer
PBS
Preservative
0.1% Sodium Azide
Concentration
1.0 mg/ml
Purity
Immunogen affinity purified
Alternate Names for KiSS1R/GPR54 Antibody - BSA Free
AXOR12
AXOR12hypogonadotropin-1
G protein-coupled receptor 54
GPR54
GPR54kiSS-1R
G-protein coupled receptor 54
G-protein coupled receptor OT7T175
HOT7T175
Hypogonadotropin-1
KISS1 receptor
kiSS-1 receptor
KiSS1R
KiSS-1R
Kisspeptins receptor
Metastin Receptor
OT7T175
Background
GPR54 is a Metastin Receptor. Metastin, also known as KiSS-1, is a metastasis suppressor gene. Mutations in GPR54 have been shown to cause autosomal recessive idiopathic hypogonadotropic hypogonadism in humans and mice, suggesting that GPR54 is a key regulator for the onset of puberty (Seminara et al. 2003). GPR54 has been reported in various human brain regions, placenta, pancreas, and spinal cord, and at lower levels in spleen, peripheral blood leukocytes, testis, lymph node, thymus, small intestine, stomach, lung, and kidney. The receptor is also abundant in tumor tissues. In rat, GPR54 is expressed in liver, intestine, and in the pons, midbrain, thalamus, hypothalamus, hippocampus, amygdala, cortex (including frontal), and striatum. ESTs have been isolated from normal placenta and kidney cancer libraries.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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