KiSS1R/GPR54 Products

Description

GPR54 is a Metastin Receptor. Metastin, also known as KiSS-1, is a metastasis suppressor gene. Mutations in GPR54 have been shown to cause autosomal recessive idiopathic hypogonadotropic hypogonadism in humans and mice, suggesting that GPR54 is a key regulator for the onset of puberty (Seminara et al. 2003). GPR54 has been reported in various human brain regions, placenta, pancreas, and spinal cord, and at lower levels in spleen, peripheral blood leukocytes, testis, lymph node, thymus, small intestine, stomach, lung, and kidney. The receptor is also abundant in tumor tissues. In rat, GPR54 is expressed in liver, intestine, and in the pons, midbrain, thalamus, hypothalamus, hippocampus, amygdala, cortex (including frontal), and striatum. ESTs have been isolated from normal placenta and kidney cancer libraries.

Bioinformatics

Entrez	84634 Human
Uniprot	Q969F8 Human
Product By Gene ID	84634
Alternate Names	AXOR12hypogonadotropin-1 G protein-coupled receptor 54 GPR54kiSS-1R G-protein coupled receptor 54 G-protein coupled receptor OT7T175 hOT7T175 HOT7T175 Hypogonadotropin-1 KISS1 receptor kiSS-1 receptor KiSS-1R Kisspeptins receptor Metastin receptor

Research Areas for KiSS1R/GPR54

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GPCR