IRS2 Products

Description

Insulin receptor substrates (IRS), the major intracellular substrates of the insulin receptor (IR), are adaptor proteins that transduce signals from the IR to downstream effectors that are important for the biological effect of insulin (1-2). After insulin stimulation, IRS proteins are rapidly phosphorylated on multiple tyrosine residues. Once phosphorylated, IRS proteins bind and activate Grb-2, SHP2 and the PI3-K p85 subunit (2-3). Sequences of IRS-2 and IRS-1 reveal a highly conserved amino terminus containing a pleckstrin-homology domain and a phosphotyrosine-binding domain, and a poorly conserved carboxy terminus containing several tyrosine phosphorylation motifs. IRS-2 is expressed in many cells, including tissues from IRS-1-/- mice, and may be essential for signaling by several receptor systems such as insulin and cytokine (1).

Bioinformatics

Entrez	29376 Rat 384783 Mouse 8660 Human
Uniprot	NP_003740 Human NP_003740.2 Human Q9Y4H2 Human
Product By Gene ID	8660
Alternate Names	insulin receptor substrate 2 IRS-2

Research Areas for IRS2

Find related products by research area and learn more about each of the different research areas below.

Cell Cycle and Replication
Lipid and Metabolism
Nutrient Sensing in the Brain
Phospho-Specific
Signal Transduction