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Integrin alpha V beta 3 Antibody (27.1 (VNR-1)) [DyLight 755]

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications ICC/IF, IHC, IP, IHC-P (-)
Clone
27.1 (VNR-1)
Clonality
Monoclonal
Host
Mouse
Conjugate
DyLight 755

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 350
NBP2-29719AF350
Alexa Fluor 405
NBP2-29719AF405
Alexa Fluor 488
NBP2-29719AF488
Alexa Fluor 532
NBP2-29719AF532
Alexa Fluor 594
NBP2-29719AF594
Alexa Fluor 647
NBP2-29719AF647
Alexa Fluor 700
NBP2-29719AF700
Alexa Fluor 750
NBP2-29719AF750
Biotin
NBP2-29719B
CoraFluor 1
NBP2-29719CL1
DyLight 350
NBP2-29719UV
DyLight 405
NBP2-29719V
DyLight 488
NBP2-29719G
DyLight 550
NBP2-29719R
DyLight 594
NBP2-29719DL594
DyLight 650
NBP2-29719C
DyLight 680
NBP2-29719FR
FITC
NBP2-29719F
HRP
NBP2-29719H
Janelia Fluor 525
NBP2-29719JF525
Janelia Fluor 549
NBP2-29719JF549
Janelia Fluor 646
NBP2-29719JF646
Janelia Fluor 669
NBP2-29719JF669
Unconjugated
NBP2-29719
View Available Formulations
Catalog# & Formulation Size Price
Standard Formulation
NBP2-29719
BSA Free
NBP2-29719
BSA Free
NBP2-29719-0.025mg
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Integrin alpha V beta 3 Antibody (27.1 (VNR-1)) [DyLight 755] Summary

Immunogen
This antibody is specific to Integrin Alpha VBeta 3
Specificity
Reacts with the human integrin alphaVbeta3. Shown to be specific for alphaVbeta3 by Loftus JC et al (1990) Science 249:915-918.
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
ITGAV
Purity
Protein A purified
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Applications/Dilutions

Dilutions
  • Immunocytochemistry/ Immunofluorescence
  • Immunohistochemistry
  • Immunoprecipitation
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Reactivity Notes

0

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Protein A purified

Notes



DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

Alternate Names for Integrin alpha V beta 3 Antibody (27.1 (VNR-1)) [DyLight 755]

  • antigen identified by monoclonal L230
  • CD51 antigen
  • CD51
  • Integrin alpha V beta 3
  • integrin alpha-V
  • integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)
  • MSK8
  • Vitronectin receptor subunit alpha
  • VNRADKFZp686A08142

Background

Integrins are heterodimeric cell surface receptors composed of alpha and beta subunits, which mediate cell-cell and cell-extracellular matrix attachments. Aberrant integrin expression has been found in many epithelial tumours. Changes in integrin expression have been shown to be important for the growth and early metastatic capacity of melanoma cells. Integrin alpha V beta 3 is the predominant integrin of osteoclasts (bone resorbing cells) and is upregulated in malignant melanoma. Integrin alpha V beta 3 binds to a range of ECM proteins (e.g. vitronectin, fibrinogen, fibronectin) via an Arg-Gly-Asp (RGD) motif.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

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Bioinformatics

Gene Symbol ITGAV