Species: Hu
Applications: Flow, IHC, IP, CyTOF-ready
Host: Mouse Monoclonal
Species: Hu
Applications: Flow, CyTOF-ready
Host: Rabbit Monoclonal
Species: Hu, Rt, Ch
Applications: ELISA, Flow, ICC/IF, IHC, IP
Host: Mouse Monoclonal
Species: Hu
Applications: Binding Activity
Species: Mu
Applications: Bioactivity
Species: Pm-Cm
Applications: Bioactivity
Description
Integrins are heterodimeric cell surface receptors composed of alpha and beta subunits, which mediate cell-cell and cell-extracellular matrix attachments. Aberrant integrin expression has been found in many epithelial tumours. Changes in integrin expression have been shown to be important for the growth and early metastatic capacity of melanoma cells. Integrin alpha V beta 3 is the predominant integrin of osteoclasts (bone resorbing cells) and is upregulated in malignant melanoma. Integrin alpha V beta 3 binds to a range of ECM proteins (e.g. vitronectin, fibrinogen, fibronectin) via an Arg-Gly-Asp (RGD) motif.
Bioinformatics
| Entrez |
Human
|
| Product By Gene ID |
3685 |
| Alternate Names |
- antigen identified by monoclonal L230
- CD51 antigen
- CD51
- integrin alpha-V
- integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)
- MSK8
- Vitronectin receptor subunit alpha
- VNRADKFZp686A08142
|
![Flow Cytometry Integrin alpha V beta 3 Antibody (2549B) [Unconjugated]](http://images.novusbio.com/fullsize2/Integrin_alpha_V_MAB12192_Flow_Cytometry_23931.jpg)
![Binding Activity Integrin alpha V beta 3 [Unconjugated]](http://images.novusbio.com/fullsize2/Integrin_alpha_V_beta_3_10426AV_3133.jpg)
![SDS-PAGE Integrin alpha V beta 3 [Unconjugated]](http://images.novusbio.com/fullsize2/Integrin_alpha_V_beta_3_10426AV_3058.jpg)