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Integrin alpha V beta 3 Antibody (2549B) [DyLight 488]

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications Flow, CyTOF-ready
Clone
2549B
Clonality
Monoclonal
Host
Rabbit
Conjugate
DyLight 488

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 350
FAB12192U-100UG
Alexa Fluor 405
FAB12192V-100UG
Alexa Fluor 488
FAB12192G-100UG
Alexa Fluor 532
FAB12192X
Alexa Fluor 594
FAB12192T-100UG
Alexa Fluor 647
FAB12192R-100UG
Alexa Fluor 700
FAB12192N-100UG
Alexa Fluor 750
FAB12192S-100UG
Allophycocyanin
FAB12192A
Allophycocyanin/Cy7
FAB12192APCCY7
Biotin
FAB12192B
CoraFluor 1
FAB12192CL1
DyLight 350
FAB12192D
DyLight 405
FAB12192E
DyLight 550
FAB12192L
DyLight 594
FAB12192M
DyLight 650
FAB12192W
DyLight 680
FAB12192Y
DyLight 755
FAB12192Z
FITC
FAB12192F
HRP
FAB12192H
Janelia Fluor 525
FAB12192JF525
Janelia Fluor 549
FAB12192I
Janelia Fluor 646
FAB12192J
Janelia Fluor 669
FAB12192JF669
PE
FAB12192P
PE/Atto594
FAB12192PEATT594
PE/Cy5.5
FAB12192PECY55
PE/Cy7
FAB12192PECY7
PerCP
FAB12192C
Unconjugated
MAB12192-100
mFluor Violet 450 SE
FAB12192MFV450
mFluor Violet 500 SE
FAB12192MFV500
mFluor Violet 610 SE
FAB12192MFV610
View Available Formulations
Catalog# & Formulation Size Price
Standard Formulation
MAB12192-100
Carrier Free
MAB12192-100
Carrier Free
MAB12192-SP
Carrier Free
FAB12192V-100UG
Carrier Free
FAB12192U-100UG
Carrier Free
FAB12192T-100UG
Carrier Free
FAB12192S-100UG
Carrier Free
FAB12192R-100UG
Carrier Free
FAB12192N-100UG
Carrier Free
FAB12192G-100UG
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Integrin alpha V beta 3 Antibody (2549B) [DyLight 488] Summary

Additional Information
Recombinant Monoclonal Antibody
Immunogen
Chinese Hamster Ovary cell line CHO-derived human Integrin alpha V beta 3.
Human Integrin alpha V (Phe31-Val992) and Human Integrin beta 3 (Gly27-Asp718)
Accession # NP_002201 and AAA52589
Specificity
In ELISAs, it detects recombinant human Integrin  alpha V beta 3 heterodimer, but does not detect recombinant human Integrin  alpha V beta 1 and Integrin  alpha 6 beta 1 heterodimers or recombinant human Integrin  alpha V monomer.
Isotype
IgG
Clonality
Monoclonal
Host
Rabbit
Purity
Protein A or G purified from cell culture supernatant
Innovator's Reward
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Applications/Dilutions

Dilutions
  • CyTOF-ready
  • Flow Cytometry
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Protein A or G purified from cell culture supernatant

Notes

DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

Alternate Names for Integrin alpha V beta 3 Antibody (2549B) [DyLight 488]

  • antigen identified by monoclonal L230
  • CD51 antigen
  • CD51
  • Integrin alpha V beta 3
  • integrin alpha-V
  • integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)
  • MSK8
  • Vitronectin receptor subunit alpha
  • VNRADKFZp686A08142

Background

Integrins are heterodimeric cell surface receptors composed of alpha and beta subunits, which mediate cell-cell and cell-extracellular matrix attachments. Aberrant integrin expression has been found in many epithelial tumours. Changes in integrin expression have been shown to be important for the growth and early metastatic capacity of melanoma cells. Integrin alpha V beta 3 is the predominant integrin of osteoclasts (bone resorbing cells) and is upregulated in malignant melanoma. Integrin alpha V beta 3 binds to a range of ECM proteins (e.g. vitronectin, fibrinogen, fibronectin) via an Arg-Gly-Asp (RGD) motif.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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