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Integrin alpha V beta 3 Antibody (23C6) [PE/Cy5.5]

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications Flow
Clone
23C6
Clonality
Monoclonal
Host
Mouse
Conjugate
PE/Cy5.5

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 350
FAB3050U-100UG
Alexa Fluor 405
FAB3050V-100UG
Alexa Fluor 488
FAB3050G
Alexa Fluor 532
FAB3050X
Alexa Fluor 594
FAB3050T-100UG
Alexa Fluor 647
FAB3050R-100UG
Alexa Fluor 700
FAB3050N-100UG
Alexa Fluor 750
FAB3050S-100UG
Allophycocyanin
FAB3050A
Allophycocyanin/Cy7
FAB3050APCCY7
Biotin
FAB3050B
CoraFluor 1
FAB3050CL1
DyLight 350
FAB3050D
DyLight 405
FAB3050E
DyLight 488
FAB3050K
DyLight 550
FAB3050L
DyLight 594
FAB3050M
DyLight 650
FAB3050W
DyLight 680
FAB3050Y
DyLight 755
FAB3050Z
FITC
FAB3050F
HRP
FAB3050H
Janelia Fluor 525
FAB3050JF525
Janelia Fluor 549
FAB3050I
Janelia Fluor 646
FAB3050J
Janelia Fluor 669
FAB3050JF669
PE/Atto594
FAB3050PEATT594
PE/Cy7
FAB3050PECY7
PerCP
FAB3050C
Unconjugated
FAB3050A
mFluor Violet 450 SE
FAB3050MFV450
mFluor Violet 500 SE
FAB3050MFV500
mFluor Violet 610 SE
FAB3050MFV610
View Available Formulations
Catalog# & Formulation Size Price
Standard Formulation
FAB3050A
Carrier Free
FAB3050A
Carrier Free
FAB3050G
Carrier Free
FAB3050V-100UG
Carrier Free
FAB3050U-100UG
Carrier Free
FAB3050T-100UG
Carrier Free
FAB3050S-100UG
Carrier Free
FAB3050R-100UG
Carrier Free
FAB3050N-100UG
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Integrin alpha V beta 3 Antibody (23C6) [PE/Cy5.5] Summary

Immunogen
Human osteoclasts
Specificity
Detects human Integrin alpha V beta 3.
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
ITGAV
Purity
Protein A or G purified from hybridoma culture supernatant
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.
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Applications/Dilutions

Dilutions
  • Flow Cytometry
Application Notes
Optimal dilution of this antibody should be experimentally determined. For optimal results using our Tandem dyes, please avoid prolonged exposure to light or extreme temperature fluctuations. These can lead to irreversible degradation or decoupling. When staining intracellular targets, specific attention to the fixation and permeabilization steps in your flow protocol may be required. Please contact our technical support team at technical@novusbio.com if you have any questions.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark. Do not freeze.
Buffer
PBS
Preservative
0.05% Sodium Azide
Purity
Protein A or G purified from hybridoma culture supernatant

Alternate Names for Integrin alpha V beta 3 Antibody (23C6) [PE/Cy5.5]

  • antigen identified by monoclonal L230
  • CD51 antigen
  • CD51
  • Integrin alpha V beta 3
  • integrin alpha-V
  • integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)
  • MSK8
  • Vitronectin receptor subunit alpha
  • VNRADKFZp686A08142

Background

Integrins are heterodimeric cell surface receptors composed of alpha and beta subunits, which mediate cell-cell and cell-extracellular matrix attachments. Aberrant integrin expression has been found in many epithelial tumours. Changes in integrin expression have been shown to be important for the growth and early metastatic capacity of melanoma cells. Integrin alpha V beta 3 is the predominant integrin of osteoclasts (bone resorbing cells) and is upregulated in malignant melanoma. Integrin alpha V beta 3 binds to a range of ECM proteins (e.g. vitronectin, fibrinogen, fibronectin) via an Arg-Gly-Asp (RGD) motif.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol ITGAV