Integrin alpha 7 Antibody

ITGA7 encodes integrin alpha chain 7. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 7 undergoes post-translational cleavage within the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form an integrin that binds to the extracellular matrix protein laminin-1. Alpha 7 beta 1 is the major integrin complex expressed in differentiated muscle cells. Splice variants of alpha 7 that differ in both the extracellular and cytoplasmic domains exist in the mouse; however, to date only a single human transcript type has been isolated: it contains extracellular and cytoplasmic domains corresponding to the mouse X2 and B variants, respectively. A unique extracellular splice variant has been identified in human, although it clearly represents a minor species and its biological significance is unclear.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 1 application: IF/IHC.

Showing Publication 1 - 1 of 1.

Publication using NBP1-86118	Applications	Species
Gonzalez Porras MA, Stojkova K, Vaicik MK et al. Integrins and extracellular matrix proteins modulate adipocyte thermogenic capacity Scientific reports 2021-03-08 [PMID: 33686208] (IF/IHC, Mouse)	IF/IHC	Mouse

Images	Ratings	Applications	Species	Date	Details
Enlarge	4 reviewed by: Verified Customer	ICC	Bovine	03/20/2018	View Summary Application Immunocytochemistry Sample Tested skeletal muscle derived cells Species Bovine Lot A83179 Comments Comments Mononucleated cells containing satellite cells and fibroblasts were isolated from bovine skeletal muscle tissue and induced for myogenic differentiation. Cells were fixed in methanol and stained using anti-myosin antibody and anti-Integrin a7 (#NBP1-86118) antibody. Corresponding secondary antibodies were used to visualize the result. Strong integrin a7 signal was observed in myotubes. But some weaker signals were also observed in fibroblasts which are known to be negative for it.

Array NBP1-86118

• Integrin alpha 7 Antibodies
• Integrin alpha 7 Proteins