Integrin alpha 7 Products

Description

ITGA7 encodes integrin alpha chain 7. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 7 undergoes post-translational cleavage within the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form an integrin that binds to the extracellular matrix protein laminin-1. Alpha 7 beta 1 is the major integrin complex expressed in differentiated muscle cells. Splice variants of alpha 7 that differ in both the extracellular and cytoplasmic domains exist in the mouse; however, to date only a single human transcript type has been isolated: it contains extracellular and cytoplasmic domains corresponding to the mouse X2 and B variants, respectively. A unique extracellular splice variant has been identified in human, although it clearly represents a minor species and its biological significance is unclear.

Bioinformatics

Entrez	3679 Human
Uniprot	NP_002197 Human Q13683 Human Q61738 Mouse
Product By Gene ID	3679
Alternate Names	FLJ25220 integrin alpha 7 chain integrin alpha-7 integrin, alpha 7

Research Areas for Integrin alpha 7

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Signal Transduction