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Integrin alpha 2b/CD41 Antibody (745201) [DyLight 594]

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, Flow, CyTOF-ready
Clone
745201
Clonality
Monoclonal
Host
Mouse
Conjugate
DyLight 594

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 350
FAB7616U-100UG
Alexa Fluor 405
FAB7616V-100UG
Alexa Fluor 488
FAB7616G-100UG
Alexa Fluor 532
FAB7616X
Alexa Fluor 594
FAB7616T-100UG
Alexa Fluor 647
FAB7616R-100UG
Alexa Fluor 700
FAB7616N-100UG
Alexa Fluor 750
FAB7616S-100UG
Allophycocyanin
FAB7616A
Allophycocyanin/Cy7
FAB7616APCCY7
Biotin
FAB7616B
DyLight 350
FAB7616D
DyLight 405
FAB7616E
DyLight 488
FAB7616K
DyLight 550
FAB7616L
DyLight 650
FAB7616W
DyLight 680
FAB7616Y
DyLight 755
FAB7616Z
FITC
FAB7616F
HRP
FAB7616H
Janelia Fluor 549
FAB7616I
Janelia Fluor 646
FAB7616J
PE/Atto594
FAB7616PEATT594
PE/Cy5.5
FAB7616PECY55
PE/Cy7
FAB7616PECY7
PerCP
FAB7616C
Phycoerythrin
FAB7616P
Unconjugated
MAB7616
mFluor Violet 450 SE
FAB7616MFV450
mFluor Violet 500 SE
FAB7616MFV500
mFluor Violet 610 SE
FAB7616MFV610
View Available Formulations
Catalog# & Formulation Size Price
Standard Formulation
MAB7616
Carrier Free
FAB7616P
Carrier Free
MAB7616
Carrier Free
FAB7616A
Carrier Free
MAB7616-SP
Carrier Free
FAB7616V-100UG
Carrier Free
FAB7616U-100UG
Carrier Free
FAB7616T-100UG
Carrier Free
FAB7616S-100UG
Carrier Free
FAB7616R-100UG
Carrier Free
FAB7616N-100UG
Carrier Free
FAB7616G-100UG
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Integrin alpha 2b/CD41 Antibody (745201) [DyLight 594] Summary

Immunogen
heterodimer of human Integrin alpha 2B (Leu32-Arg993; R887L) Accession P08514 + human Integrin beta 3 (Gly27-Asp718) Accession P05106
Specificity
Detects human Integrin alpha 2b/CD41 in direct ELISAs. In direct ELISAs, no cross-reactivity with recombinant human Integrin alpha 5, alpha 8, alpha V, beta 3, beta 5, beta 6, recombinant mouse Integrin beta 2b or beta 3 is observed.
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
ITGA2B
Purity
Protein A or G purified from hybridoma culture supernatant
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Applications/Dilutions

Dilutions
  • CyTOF-ready
  • Flow Cytometry
  • Western Blot
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Protein A or G purified from hybridoma culture supernatant

Notes

DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

Alternate Names for Integrin alpha 2b/CD41 Antibody (745201) [DyLight 594]

  • CD41 antigen
  • CD41
  • CD41BHPA3
  • GP2B
  • GP2Bintegrin alpha-IIb
  • GPalpha IIb
  • GPIIb
  • GTA
  • HPA3
  • Integrin alpha 2b
  • integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigenCD41)
  • integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigenCD41B)
  • ITGA2b
  • ITGAB
  • platelet fibrinogen receptor, alpha subunit
  • Platelet membrane glycoprotein IIb
  • platelet-specific antigen BAK

Background

Integrin alpha 2b (CD41) is a calcium-dependent, noncovalently associated heterodimer and contains a heavy chain (GPIIb alpha) and a light chain (GPIIb beta) linked by a single disulfide bond. The Integrin alpha 2B chain interacts with the Integrin beta 3 subunit/CD61 to form the platelet glycoprotein complex, gpIIb/IIIa. It is expressed on platelets and megakaryocytes. Ligands for the gpIIb/IIIa heterodimer include fibrinogen, von Willebrand factor, fibronectin, vitronectin, and thrombospondin. The gpIIb/IIIa complex is the major Integrin on platelets and is important for platelet adhesion and aggregation.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol ITGA2B