ASAH1 Antibody

ASAH1 encodes a heterodimeric protein consisting of a nonglycosylated alpha subunit and a glycosylated beta subunit that is cleaved to the mature enzyme posttranslationally. The encoded protein catalyzes the synthesis and degradation of ceramide into sphingosine and fatty acid. Mutations in this gene have been associated with a lysosomal storage disorder known as Farber disease. Multiple transcript variants encoding several distinct isoforms have been identified for this gene. [provided by RefSeq]

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: WB.

Showing Publications 1 - 7 of 7.

Publications using NBP1-89296	Applications	Species
Torrino S, Tiroille V, Dolfi B Et al. UBTD1 regulates ceramide balance and endolysosomal positioning to coordinate EGFR signaling eLife 2021-04-22 [PMID: 33884955]
Cho SM, Lee HK, Liu Q et al. A guanidine-based synthetic compound suppresses angiogenesis via inhibition of acid ceramidase ACS Chem. Biol. 2018-12-03 [PMID: 30507149] (WB, Human)	WB	Human
Cai K, Lucki NC, Sewer MB. Silencing diacylglycerol kinase-theta expression reduces steroid hormone biosynthesis and cholesterol metabolism in human adrenocortical cells. Biochim Biophys Acta 2014-04-04 [PMID: 24369117] (WB, Human)	WB	Human
Lucki NC, Li D, Bandyopadhyay S et al. Acid Ceramidase (ASAH1) Represses Steroidogenic Factor 1-Dependent Gene Transcription in H295R Human Adrenocortical Cells by Binding to the Receptor. Mol Cell Biol 2012-11-01 [PMID: 22927646]
Lucki NC, Bandyopadhyay S, Wang E et al. Acid Ceramidase (ASAH1) Is a Global Regulator of Steroidogenic Capacity and Adrenocortical Gene Expression. Mol Endocrinol 2012-02-01 [PMID: 22261821]
Lucki NC, Sewer MB et al. Genistein stimulates MCF-7 breast cancer cell growth by inducing acid ceramidase (ASAH1) gene expression. J Biol Chem 2011-06-01 [PMID: 21493710]
Lucki N, Sewer MB et al. The cAMP-responsive element binding protein (CREB) regulates the expression of acid ceramidase (ASAH1) in H295R human adrenocortical cells. Biochim Biophys Acta 2009-08-01 [PMID: 19298866]

Array NBP1-89296

• ASAH1 Antibodies
• ASAH1 ELISA Kit
• ASAH1 Lysate
• ASAH1 Proteins