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Insulin Antibody (E2-E3 + 2D11-H5 (same as INS04 + INS05)) [DyLight 650]

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Product Details

Summary
Reactivity Hu, Mu, Po, Bv, RbSpecies Glossary
Applications IHC
Clone
E2-E3 + 2D11-H5 (same as INS04 + INS05)
Clonality
Monoclonal
Host
Mouse
Conjugate
DyLight 650

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 350
NBP2-34612AF350
Alexa Fluor 405
NBP2-34612AF405
Alexa Fluor 488
NBP2-34612AF488
Alexa Fluor 532
NBP2-34612AF532
Alexa Fluor 594
NBP2-34612AF594
Alexa Fluor 647
NBP2-34612AF647
Alexa Fluor 700
NBP2-34612AF700
Alexa Fluor 750
NBP2-34612AF750
Biotin
NBP2-34612B
DyLight 350
NBP2-34612UV
DyLight 405
NBP2-34612V
DyLight 488
NBP2-34612G
DyLight 550
NBP2-34612R
DyLight 594
NBP2-34612DL594
DyLight 680
NBP2-34612FR
DyLight 755
NBP2-34612IR
FITC
NBP2-34612F
HRP
NBP2-34612H
Janelia Fluor 549
NBP2-34612JF549
Janelia Fluor 646
NBP2-34612JF646
Unconjugated
NBP2-34261-0.1mg
View Available Formulations
Catalog# & Formulation Size Price
Standard Formulation
NBP2-34261-0.1mg
IHC-Prediluted
NBP2-45107
Azide and BSA Free
NBP2-34612-0.1mg
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Insulin Antibody (E2-E3 + 2D11-H5 (same as INS04 + INS05)) [DyLight 650] Summary

Description
This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.
Immunogen
Purified pig insulin, conjugated to KLH (E2-E3 & 2D11-H5) (Uniprot: P01308)
Localization
Cytoplasmic
Marker
beta-Cell & Insulinoma Marker
Specificity
Recognizes a polypeptide which is identified as insulin, a 51-amino acid polypeptide composed of A and B chains connected through the C-peptide. Proinsulin, which has very little biological activity, is cleaved by proteases within its cell of origin into the insulin molecule and the C-terminal basic residue. Insulin enhances membrane transport of glucose, amino acids, and certain ions. It also promotes glycogen storage, formation of triglycerides, and synthesis of proteins and nucleic acids. Deficiency of insulin results in diabetes mellitus. The main storage site for insulin is the pancreatic islets. Antibodies to insulin are important as beta-cell and insulinoma marker.
Isotype
IgG1 Kappa/IgG1 Kappa
Clonality
Monoclonal
Host
Mouse
Gene
INS
Purity
Protein G purified
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Applications/Dilutions

Dilutions
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Protein G purified

Notes



DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

Alternate Names for Insulin Antibody (E2-E3 + 2D11-H5 (same as INS04 + INS05)) [DyLight 650]

  • IDDM2
  • ILPR
  • INS
  • Insulin
  • IRDN
  • MODY10
  • proinsulin

Background

After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into two chains (peptide A and peptide B) that are covalently linked via two disulfide bonds. Binding of this mature form of insulin to the insulin receptor (INSR) stimulates glucose uptake. A variety of mutant alleles with changes in the coding region have been identified. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5' region and with the IGF2 gene at the 3' region. (provided by RefSeq)

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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FAQs for Insulin Antibody (NBP2-34612C). (Showing 1 - 1 of 1 FAQ).

  1. Will you please recommend me antibodies to insulin, the most suitable for immunohistochemistry in the pancreas of guinea pigs? Desirable to be conjugated with some pigment and there was no need for secondary antibodies.
    • I have carried out a search and the best antibody I recommend is NB600-1488. This is a primary unconjugated antibody however and you will need a secondary. If you click on the product link and then click on related products, a list of all recommended secondary antibodies will appear.

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Bioinformatics

Gene Symbol INS