IL-15 Antibody (34559) [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Interleukin 15 (IL-15) is a widely expressed 14 kDa cytokine that is structurally and functionally related to IL-2 (1‑3). Mature human IL‑15 shares 70% amino acid sequence identity with mouse and rat IL-15. Alternate splicing generates isoforms of IL-15 with either a long or short signal peptide (LSP or SSP), and the SSP isoform is retained intracellularly (4). IL-15 binds with high affinity to IL-15 R alpha (5). It binds with lower affinity to a complex of IL-2 R beta and the common gamma chain ( gamma c) which are also subunits of the IL-2 receptor complex (1, 6). IL-15 associates with IL-15 R alpha in the endoplasmic reticulum, and this complex is expressed on the cell surface (7, 8). The dominant mechanism of IL-15 action is known as transpresentation in which IL-15 and IL-15 R alpha are coordinately expressed on the surface of one cell and interact with complexes of IL-2 R beta / gamma c on adjacent cells (9). This enables cells to respond to IL-15 even if they do not express IL-15 R alpha (8, 10). Soluble IL-15-binding forms of IL-15 R alpha can be generated by proteolytic shedding or alternate splicing (11‑13). These molecules retain the ability to bind tightly to IL-15 and can either inhibit or augment IL-15 function (5, 12, 13). Consistent with its shared use of IL-2 receptor subunits, IL-15 induces IL-2-like effects in lymphocyte development and homeostasis (3). It is particularly important for the maintenance and activation of NK cells and CD8⁺ memory T cells (3). IL-15 also exerts pleiotropic effects on other hematopoietic cells and non-immune cells (2). Ligation of membrane-associated IL-15/IL-15 R alpha complexes induces reverse signaling that promotes cellular adhesion, tyrosine phosphorylation of intracellular proteins, and cytokine secretion by the IL-15/IL-15 R alpha expressing cells (14, 15).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 5 applications: Blocking, Cell Culture, Flow Cytometry, Neutralization, Western Blot.

Showing Publications 1 - 10 of 16. Show All 16 Publications. Collapse Publications.

Publications using MAB2471	Applications	Species
Yasmin Shakiba, Pavel O. Vorobyev, Gaukhar M. Yusubalieva, Dmitry V. Kochetkov, Ksenia V. Zajtseva, Marat P. Valikhov et al. Oncolytic therapy with recombinant vaccinia viruses targeting the interleukin-15 pathway elicits a synergistic response Molecular Therapy - Oncolytics 6/15/2023 [PMID: 37387795]
Y Rodríguez-, LG Batista-Ro, A Llopiz-Arz, P Puente-Pér, R Martínez-C, J Castro-Vel, A Santos-Sav Immunogenicity profile in African green monkeys of a vaccine candidate based on a mutated form of human Interleukin-15 BMC immunology, 2021-12-18;22(1):79. 2021-12-18 [PMID: 34922462] (Neutralization, Mouse)	Neutralization	Mouse
S Panigrahi, B Chen, M Fang, D Potashniko, AA Komissarov, A Lebedeva, GM Michaelson, JM Wyrick, SR Morris, SF Sieg, M Paiardini, FJ Villinger, K Harth, VS Kashyap, MJ Cameron, CM Cameron, E Vasilieva, L Margolis, SA Younes, NT Funderburg, DA Zidar, MM Lederman, ML Freeman CX3CL1 and IL-15 Promote CD8 T cell chemoattraction in HIV and in atherosclerosis PLoS Pathog, 2020-09-25;16(9):e1008885. 2020-09-25 [PMID: 32976527] (Cell Culture, Human)	Cell Culture	Human
P Oberoi, K Kamenjarin, JFV Ossa, B Uherek, H Bönig, WS Wels Directed Differentiation of Mobilized Hematopoietic Stem and Progenitor Cells into Functional NK cells with Enhanced Antitumor Activity Cells, 2020-03-27;9(4):. 2020-03-27 [PMID: 32230942] (Flow Cytometry, Human)	Flow Cytometry	Human
Laurent Vidard, Christine Dureuil, Jérémy Baudhuin, Lionel Vescovi, Laurence Durand, Véronique Sierra et al. CD137 (4-1BB) Engagement Fine-Tunes Synergistic IL-15– and IL-21–Driven NK Cell Proliferation The Journal of Immunology 8/1/2019 [PMID: 31201235]
H Touil, A Kobert, N Lebeurrier, A Rieger, P Saikali, C Lambert, L Fawaz, CS Moore, A Prat, J Gommerman, JP Antel, Y Itoyama, I Nakashima, A Bar-Or Human central nervous system astrocytes support survival and activation of B cells: implications for MS pathogenesis J Neuroinflammation, 2018-04-19;15(1):114. 2018-04-19 [PMID: 29673365] (Neutralization, Human)	Neutralization	Human
YE Du, G Tu, G Yang, G Li, D Yang, L Lang, L Xi, K Sun, Y Chen, K Shu, H Liao, M Liu, Y Hou MiR-205/YAP1 in Activated Fibroblasts of Breast Tumor Promotes VEGF-independent Angiogenesis through STAT3 Signaling Theranostics, 2017-09-15;7(16):3972-3988. 2017-09-15 [PMID: 29109792] (Neutralization, Human)	Neutralization	Human
JMJ Van den Be, ELJM Smits, M Versteven, H De Reu, ZN Berneman, VFI Van Tendel, E Lion Characterization of Interleukin-15-Transpresenting Dendritic Cells for Clinical Use J Immunol Res, 2017-07-13;2017(0):1975902. 2017-07-13 [PMID: 28785596] (Flow Cytometry, Human)	Flow Cytometry	Human
R Ciccociopp, A Gallia, MA Avanzini, E Betti, C Picone, A Vanoli, C Paganini, F Biagi, R Maccario, GR Corazza A Refractory Celiac Patient Successfully Treated With Mesenchymal Stem Cell Infusions Mayo Clin Proc, 2016-04-14;0(0):. 2016-04-14 [PMID: 27087453] (Western Blot, Human)	Western Blot	Human
Anguille S, Van Acker H, Van den Bergh J, Willemen Y, Goossens H, Van Tendeloo V, Smits E, Berneman Z, Lion E Interleukin-15 Dendritic Cells Harness NK Cell Cytotoxic Effector Function in a Contact- and IL-15-Dependent Manner. PLoS ONE, 2015-05-07;10(5):e0123340. 2015-05-07 [PMID: 25951230] (Neutralization, Human)	Neutralization	Human
Tsai C, Liong K, Gunalan M, Li N, Lim D, Fisher D, Macary P, Leo Y, Wong S, Puan K, Wong S Type I IFNs and IL-18 regulate the antiviral response of primary human gammadelta T cells against dendritic cells infected with Dengue virus. J Immunol, 2015-03-02;194(8):3890-900. 2015-03-02 [PMID: 25732728] (Neutralization, Human)	Neutralization	Human
Marra P, Mathew S, Grigoriadis A, Wu Y, Kyle-Cezar F, Watkins J, Rashid M, De Rinaldis E, Hessey S, Gazinska P, Hayday A, Tutt A IL15RA drives antagonistic mechanisms of cancer development and immune control in lymphocyte-enriched triple-negative breast cancers. Cancer Res, 2014-06-30;74(17):4908-21. 2014-06-30 [PMID: 24980552] (Blocking, Human)	Blocking	Human
Ana Cecilia Machado Diaz, Araceli Chico Capote, Celia Aurora Arrieta Aguero, Yunier Rodríguez Alvarez, Diana García del Barco Herrera, Miguel Estévez del Toro et al. Proinflammatory Soluble Interleukin-15 Receptor Alpha Is Increased in Rheumatoid Arthritis Arthritis 7/25/2012 [PMID: 22888423]
Muntasell A, Magri G, Pende D, Angulo A, Lopez-Botet M Inhibition of NKG2D expression in NK cells by cytokines secreted in response to human cytomegalovirus infection. Blood, 2010-04-14;115(25):5170-9. 2010-04-14 [PMID: 20393128] (Neutralization, Human)	Neutralization	Human
Tsukamoto K, Huang YC, Dorsey WC, Carns B, Sharma V Juxtacrine function of interleukin-15/interleukin-15 receptor system in tumour derived human B-cell lines. Clin. Exp. Immunol., 2006-12-01;146(3):559-66. 2006-12-01 [PMID: 17100778] (Flow Cytometry, Human)	Flow Cytometry	Human
Ong PY, Hamid QA, Travers JB, Strickland I, Al Kerithy M, Boguniewicz M, Leung DY Decreased IL-15 may contribute to elevated IgE and acute inflammation in atopic dermatitis. J. Immunol., 2002-01-01;168(1):505-10. 2002-01-01 [PMID: 11751999] (Flow Cytometry, Human)	Flow Cytometry	Human
Show All 16 Publications. Collapse Publications.

Array MAB2471

• IL-15 Antibodies
• IL-15 Antibody Pair
• IL-15 ELISA Kits
• IL-15 Lysate
• IL-15 Proteins
• IL-15 ELISAs
• IL-15 Proteins and Enzymes