IL-15 Antibody (34559) [Phycoerythrin]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Interleukin 15 (IL-15) is a widely expressed 14 kDa cytokine that is structurally and functionally related to IL-2 (1‑3). Mature human IL‑15 shares 70% amino acid sequence identity with mouse and rat IL-15. Alternate splicing generates isoforms of IL-15 with either a long or short signal peptide (LSP or SSP), and the SSP isoform is retained intracellularly (4). IL-15 binds with high affinity to IL-15 R alpha (5). It binds with lower affinity to a complex of IL-2 R beta and the common gamma chain ( gamma c) which are also subunits of the IL-2 receptor complex (1, 6). IL-15 associates with IL-15 R alpha in the endoplasmic reticulum, and this complex is expressed on the cell surface (7, 8). The dominant mechanism of IL-15 action is known as transpresentation in which IL-15 and IL-15 R alpha are coordinately expressed on the surface of one cell and interact with complexes of IL-2 R beta / gamma c on adjacent cells (9). This enables cells to respond to IL-15 even if they do not express IL-15 R alpha (8, 10). Soluble IL-15-binding forms of IL-15 R alpha can be generated by proteolytic shedding or alternate splicing (11‑13). These molecules retain the ability to bind tightly to IL-15 and can either inhibit or augment IL-15 function (5, 12, 13). Consistent with its shared use of IL-2 receptor subunits, IL-15 induces IL-2-like effects in lymphocyte development and homeostasis (3). It is particularly important for the maintenance and activation of NK cells and CD8⁺ memory T cells (3). IL-15 also exerts pleiotropic effects on other hematopoietic cells and non-immune cells (2). Ligation of membrane-associated IL-15/IL-15 R alpha complexes induces reverse signaling that promotes cellular adhesion, tyrosine phosphorylation of intracellular proteins, and cytokine secretion by the IL-15/IL-15 R alpha expressing cells (14, 15).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: Flow Cytometry.

Showing Publications 1 - 10 of 12. Show All 12 Publications. Collapse Publications.

Publications using IC2471P	Applications	Species
T Gulic, G Laskarin, L Glavan, T Grubi? Kez, H Haller, D Rukavina Human Decidual CD1a+ Dendritic Cells Undergo Functional Maturation Program Mediated by Gp96 International Journal of Molecular Sciences, 2023-01-23;24(3):. 2023-01-23 [PMID: 36768601] (Flow Cytometry, Human)	Flow Cytometry	Human
LR Yang, L Li, MY Meng, WJ Wang, SL Yang, YY Zhao, RQ Wang, H Gao, WW Tang, Y Yang, LL Yang, LW Liao, ZL Hou Evaluation of piggyBac-mediated anti-CD19 CAR-T cells after ex vivo expansion with aAPCs or magnetic beads J Cell Mol Med, 2020-11-22;0(0):. 2020-11-22 [PMID: 33225580] (Flow Cytometry, Human)	Flow Cytometry	Human
Aurore Devocelle, Lola Lecru, Hélène François, Christophe Desterke, Cindy Gallerne, Pierre Eid et al. Inhibition of TGF-beta 1 Signaling by IL-15: A Novel Role for IL-15 in the Control of Renal Epithelial-Mesenchymal Transition: IL-15 Counteracts TGF-beta 1-Induced EMT in Renal Fibrosis International Journal of Cell Biology 7/7/2019 [PMID: 31360169]
R Rekik, M Smiti Khan, T Larbi, I Zamali, A Beldi-Ferc, O Kammoun, S Marzouki, S Hamzaoui, S Mrad, MR Barbouche, MH Houman, M Ben Ahmed Impaired TGF-? signaling in patients with active systemic lupus erythematosus is associated with an overexpression of IL-22 Cytokine, 2018-04-21;108(0):182-189. 2018-04-21 [PMID: 29684755] (Flow Cytometry, Human)	Flow Cytometry	Human
Sandy Azzi, Cindy Gallerne, Cristina Romei, Vincent Le Coz, Rosaria Gangemi, Krystel Khawam et al. Human Renal Normal, Tumoral, and Cancer Stem Cells Express Membrane-Bound Interleukin-15 Isoforms Displaying Different Functions1 Neoplasia 7/4/2015 [PMID: 26152359]
Anguille S, Van Acker H, Van den Bergh J, Willemen Y, Goossens H, Van Tendeloo V, Smits E, Berneman Z, Lion E Interleukin-15 Dendritic Cells Harness NK Cell Cytotoxic Effector Function in a Contact- and IL-15-Dependent Manner. PLoS ONE, 2015-05-07;10(5):e0123340. 2015-05-07 [PMID: 25951230] (Flow Cytometry, Human)	Flow Cytometry	Human
Williams M, Yousafzai Y, Cox C, Blair A, Carmody R, Sai S, Chapman K, McAndrew R, Thomas A, Spence A, Gibson B, Graham G, Halsey C Interleukin-15 enhances cellular proliferation and upregulates CNS homing molecules in pre-B acute lymphoblastic leukemia. Blood, 2014-04-03;123(20):3116-27. 2014-04-03 [PMID: 24700781] (Flow Cytometry, Human)	Flow Cytometry	Human
Bastidas S, Graw F, Smith M, Kuster H, Gunthard H, Oxenius A CD8+ T cells are activated in an antigen-independent manner in HIV-infected individuals. J Immunol, 2014-01-20;192(4):1732-44. 2014-01-20 [PMID: 24446519] (Flow Cytometry, Human)	Flow Cytometry	Human
Arneja A, Johnson H, Gabrovsek L, Lauffenburger D, White F Qualitatively different T cell phenotypic responses to IL-2 versus IL-15 are unified by identical dependences on receptor signal strength and duration. J Immunol, 2013-12-02;192(1):123-35. 2013-12-02 [PMID: 24298013] (Flow Cytometry, Human)	Flow Cytometry	Human
Scutera S, Fraone T, Musso T, Cappello P, Rossi S, Pierobon D, Orinska Z, Paus R, Bulfone-Paus S, Giovarelli M Survival and migration of human dendritic cells are regulated by an IFN-alpha-inducible Axl/Gas6 pathway. J. Immunol., 2009-08-05;183(5):3004-13. 2009-08-05 [PMID: 19657094] (Flow Cytometry, Human)	Flow Cytometry	Human
Hussain SF, Kong LY, Jordan J, Conrad C, Madden T, Fokt I, Priebe W, Heimberger AB A novel small molecule inhibitor of signal transducers and activators of transcription 3 reverses immune tolerance in malignant glioma patients. Cancer Res., 2007-10-15;67(20):9630-6. 2007-10-15 [PMID: 17942891] (Flow Cytometry, Human)	Flow Cytometry	Human
Ferlazzo G, Pack M, Thomas D, Paludan C, Schmid D, Strowig T, Bougras G, Muller WA, Moretta L, Munz C Distinct roles of IL-12 and IL-15 in human natural killer cell activation by dendritic cells from secondary lymphoid organs. Proc. Natl. Acad. Sci. U.S.A., 2004-11-09;101(47):16606-11. 2004-11-09 [PMID: 15536127] (Flow Cytometry, Human)	Flow Cytometry	Human
Show All 12 Publications. Collapse Publications.

Images	Ratings	Applications	Species	Date	Details
	5 reviewed by: Verified Customer	Flow	Mouse	01/27/2015	View Summary Application Flow Cytometry Sample Tested See PMID: 22841164 Species Mouse

Array IC2471P

• IL-15 Antibodies
• IL-15 Antibody Pair
• IL-15 ELISA Kits
• IL-15 Lysate
• IL-15 Proteins
• IL-15 ELISAs
• IL-15 Proteins and Enzymes