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IGF-I R/IGF1R [p Tyr1165, p Tyr1166] Antibody

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Western Blot: IGF-I R/IGF1R [p Tyr1165, p Tyr1166] Antibody [NB100-81983] - Western blot in MCF7 (A), MCF7-insulin-15min (B), A2780 (C) whole cell lysates. (Predicted band size: 154 kD; Observed band size: 95; 200 kD)
Western Blot: IGF-I R/IGF1R [p Tyr1165, p Tyr1166] Antibody [NB100-81983] - Western blot in MCF7 (A), MCF7-insulin-15min (B), A2780 (C) whole cell lysates. (Predicted band size: 154 kD; Observed band size: 95; 200 kD)
Immunohistochemistry-Paraffin: IGF-I R/IGF1R [p Tyr1165, p Tyr1166] Antibody [NB100-81983] - Immunohistochemical staining in human colorectal cancer formalin fixed paraffin embedded tissue section.

Product Details

Summary
Reactivity Hu, Mu, RtSpecies Glossary
Applications WB, IHC
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
1.0 mg/ml

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IGF-I R/IGF1R [p Tyr1165, p Tyr1166] Antibody Summary

Immunogen
The antiserum was produced against synthesized phosphopeptide derived from human IGF-I R/IGF1R around the phosphorylation site of tyrosine 1165/tyrosine 1166 (T-D-YP-YP-R-K).
Modification
p Tyr1165, p Tyr1166
Specificity
Detects endogenous levels of IGF-I R/IGF1R only when phosphorylated at tyrosine 1165/tyrosine1166.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
IGF1R
Purity
Immunogen affinity purified
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Applications/Dilutions

Dilutions
  • Immunohistochemistry 1:50-1:100
  • Western Blot 1:500-1:1000
Control
IGF-I R/IGF1R Overexpression Lysate
Publications
Read Publications using
NB100-81983 in the following applications:

  • WB
    2 publications

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol
Preservative
0.01% Sodium Azide
Concentration
1.0 mg/ml
Purity
Immunogen affinity purified

Alternate Names for IGF-I R/IGF1R [p Tyr1165, p Tyr1166] Antibody

  • CD221 antigen
  • CD221
  • EC 2.7.10
  • EC 2.7.10.1
  • IGF1R
  • IGF-1R
  • IGF-I R
  • IGF-I receptor
  • IGFIR
  • IGF-IR
  • IGFR
  • insulin-like growth factor 1 receptor
  • Insulin-like growth factor I receptor
  • JTK13
  • MGC142170
  • MGC142172
  • MGC18216
  • soluble IGF1R variant 1
  • soluble IGF1R variant 2

Background

There are two kinds of IGF receptors based on their relative affinities for IGF1 versus IGF2. The IGF1 receptor prefers IGF1 over IGF2 and weakly binds insulin. IGF1 receptor is a disulfide-linked heterotetrameric transmembrane protein consisting of two alpha (130 kD) and two beta (95 kD) subunits. Both the alpha and beta subunits are encoded within a single receptor precursor cDNA. The IGF1 receptor is therefore similar in structure to the insulin receptor. The proreceptor polypeptide is proteolytically cleaved and disulfide-linked to yield the mature heterotetrameric receptor. The IGF1 receptor is highly expressed in all cell types and tissues and is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for IGF-I R/IGF1R Antibody (NB100-81983)(2)

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: WB.


Filter By Application
WB
(2)
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Filter By Species
Human
(2)
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Showing Publications 1 - 2 of 2.
Publications using NB100-81983 Applications Species
Welsink T Schomburg L . Development and Diagnostic Application of a Novel Quantitative Testfor Determination and Characterization of Autoantibodies againstInsulin-like Growth Factor 1 Receptor. Thesis. 2015-01-01 (WB, Human) WB Human
Schwiebert C, Kuhnen P, Becker NP et al. Antagonistic Autoantibodies to Insulin-Like Growth Factor-1 Receptor Associate with Poor Physical Strength Int J Mol Sci 2020-01-11 [PMID: 31940750] (WB, Human) WB Human

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WB Video Protocol

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Control Lysate(s)

IGF-I R/IGF1R Overexpression Lysate

Secondary Antibodies

 

Isotype Controls

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Bioinformatics

Gene Symbol IGF1R
Entrez
Uniprot