IFN-gamma Antibody (H22) [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Interferon-gamma (IFN-gamma, IFNG), also known as type II or Immune Interferon, exerts a wide range of immunoregulatory activities and is considered to be the prototype proinflammatory cytokine. Mature human IFN-gamma exists as a non-covalently linked homodimer of 20-25 kDa molecular weight variably glycosylated subunits. It shares 86% amino acid (aa) sequence identity with rat IFN-gamma, 38-44% with bovine, canine, cotton rat, equine, feline, human, porcine and rhesus IFN‑ gamma. IFN-gamma dimers bind to IFN-gamma RI (alpha subunits) which then interact with IFN-gamma RII (beta subunits) to form the functional receptor complex of two alpha and two beta subunits. Inclusion of IFN-gamma RII increases the binding affinity for ligand and the efficiency of signal transduction. IFN-gamma is produced by a variety of immune cells under inflammatory conditions, notably by T cells and NK cells. It plays a key function in host defense by promoting the development and activation of Th1 cells, chemoattraction and activation of monocytes and macrophages, up‑regulation of antigen presentation molecules, and immunoglobulin class switching in B cells. It also exhibits antiviral, antiproliferative, and apoptotic effects. In addition, IFN-gamma functions as an anti-inflammatory mediator by promoting the development of regulatory T cells and inhibiting Th17 cell differentiation. The pleiotropic effects of IFN-gamma contribute to the development of multiple aspects of atherosclerosis.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Mouse, Transgenic Mouse.

We have publications tested in 3 applications: Bioassay, In Vivo, Neutralization.

Showing Publications 1 - 10 of 12. Show All 12 Publications. Collapse Publications.

Publications using MAB4851	Applications	Species
Rangel Rivera, GO;Dwyer, CJ;Knochelmann, HM;Smith, AS;Aksoy, BA;Cole, AC;Wyatt, MM;Kumaresan, S;Thaxton, JE;Lesinski, GB;Paulos, CM; Progressively enhancing stemness of adoptively transferred T cells with PI3K? blockade improves metabolism and anti-tumor immunity Cancer research 2023-10-06 [PMID: 37801615] (Bioassay, Transgenic Mouse)	Bioassay	Transgenic Mouse
Wai Po Chong, Mary J. Mattapallil, Kumarkrishna Raychaudhuri, So Jin Bing, Sihan Wu, Yajie Zhong et al. The Cytokine IL-17A Limits Th17 Pathogenicity via a Negative Feedback Loop Driven by Autocrine Induction of IL-24 Immunity 8/1/2020 [PMID: 32673565]
B Theivanthi, KS Evans, NC DeVito, MP Plebanek, M Sturdivant, LP Wachsmuth, AK Salama, Y Kang, D Hsu, JM Balko, DB Johnson, M Starr, AB Nixon, A Holtzhause, BA Hanks A tumor-intrinsic PD-L1-NLRP3 inflammasome signaling pathway drives resistance to anti-PD-1 immunotherapy J. Clin. Invest., 2020-05-01;0(0):. 5/1/2020 [PMID: 32017708]
Sujin An, Yung Jin Jeon, Ara Jo, Hyun Jung Lim, Young Eun Han, Sung Woo Cho et al. Initial Influenza Virus Replication Can Be Limited in Allergic Asthma Through Rapid Induction of Type III Interferons in Respiratory Epithelium Frontiers in Immunology 5/17/2018 [PMID: 29867963]
RC Davicino, SP Méndez-Hue, RJ Eliçabe, JC Stupirski, I Autenrieth, MS Di Genaro, GA Rabinovich Galectin-1-Driven Tolerogenic Programs Aggravate Yersinia enterocolitica Infection by Repressing Antibacterial Immunity J. Immunol., 2017-07-17;0(0):. 2017-07-17 [PMID: 28716827] (In Vivo, Mouse)	In Vivo	Mouse
El-Behi M, Ciric B, Dai H The encephalitogenicity of T(H)17 cells is dependent on IL-1- and IL-23-induced production of the cytokine GM-CSF. Nat. Immunol., 2011-04-24;12(6):568-75. 2011-04-24 [PMID: 21516111] (Neutralization, Mouse)	Neutralization	Mouse
Elicabe RJ, Cargnelutti E, Serer MI, Stege PW, Valdez SR, Toscano MA, Rabinovich GA, Di Genaro MS Lack of TNFR p55 results in heightened expression of IFN-gamma and IL-17 during the development of reactive arthritis. J. Immunol., 2010-09-01;185(7):4485-95. 2010-09-01 [PMID: 20810989] (Neutralization, Mouse)	Neutralization	Mouse
Srivastava K, Zhang T, Yang N, Sampson H, Li XM Anti-Asthma Simplified Herbal Medicine Intervention-induced long-lasting tolerance to allergen exposure in an asthma model is interferon-gamma, but not transforming growth factor-beta dependent. Clin. Exp. Allergy, 2010-11-01;40(11):1678-88. 2010-11-01 [PMID: 20573156] (Neutralization, Mouse)	Neutralization	Mouse
Wildbaum G, Zohar Y, Karin N Antigen-specific CD25- Foxp3- IFN-gamma(high) CD4+ T cells restrain the development of experimental allergic encephalomyelitis by suppressing Th17. Am. J. Pathol., 2010-04-09;176(6):2764-75. 2010-04-09 [PMID: 20382706] (Neutralization, Mouse)	Neutralization	Mouse
Ito H, Ando K, Ishikawa T Role of Valpha14+ NKT cells in the development of Hepatitis B virus-specific CTL: activation of Valpha14+ NKT cells promotes the breakage of CTL tolerance. Int. Immunol., 2008-05-16;20(7):869-79. 2008-05-16 [PMID: 18487227] (Neutralization, Mouse)	Neutralization	Mouse
Wan N, Dai H, Wang T, Moore Y, Zheng XX, Dai Z Bystander central memory but not effector memory CD8+ T cells suppress allograft rejection. J. Immunol., 2008-01-01;180(1):113-21. 2008-01-01 [PMID: 18097010] (Neutralization, Mouse)	Neutralization	Mouse
Seshasayee D, Lee WP, Zhou M, Shu J, Suto E, Zhang J, Diehl L, Austin CD, Meng YG, Tan M, Bullens SL, Seeber S, Fuentes ME, Labrijn AF, Graus YM, Miller LA, Schelegle ES, Hyde DM, Wu LC, Hymowitz SG, Martin F In vivo blockade of OX40 ligand inhibits thymic stromal lymphopoietin driven atopic inflammation. J. Clin. Invest., 2007-12-01;117(12):3868-3878. 2007-12-01 [PMID: 18060034] (Neutralization, Mouse)	Neutralization	Mouse
Show All 12 Publications. Collapse Publications.

Array MAB4851

• IFN-gamma Antibodies
• IFN-gamma Antibody Pairs
• IFN-gamma ELISA Kits
• IFN-gamma Kits
• IFN-gamma Lysate
• IFN-gamma Proteins
• IFN-gamma ELISAs
• IFN-gamma Proteins and Enzymes