IFN-gamma Antibody (37801/37875) [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Interferon-gamma (IFN-gamma, IFNG), also known as type II or Immune Interferon, exerts a wide range of immunoregulatory activities and is considered to be the prototype proinflammatory cytokine. Mature human IFN-gamma exists as a non-covalently linked homodimer of 20-25 kDa molecular weight variably glycosylated subunits. It shares 86% amino acid (aa) sequence identity with rat IFN-gamma, 38-44% with bovine, canine, cotton rat, equine, feline, human, porcine and rhesus IFN‑ gamma. IFN-gamma dimers bind to IFN-gamma RI (alpha subunits) which then interact with IFN-gamma RII (beta subunits) to form the functional receptor complex of two alpha and two beta subunits. Inclusion of IFN-gamma RII increases the binding affinity for ligand and the efficiency of signal transduction. IFN-gamma is produced by a variety of immune cells under inflammatory conditions, notably by T cells and NK cells. It plays a key function in host defense by promoting the development and activation of Th1 cells, chemoattraction and activation of monocytes and macrophages, up‑regulation of antigen presentation molecules, and immunoglobulin class switching in B cells. It also exhibits antiviral, antiproliferative, and apoptotic effects. In addition, IFN-gamma functions as an anti-inflammatory mediator by promoting the development of regulatory T cells and inhibiting Th17 cell differentiation. The pleiotropic effects of IFN-gamma contribute to the development of multiple aspects of atherosclerosis.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 4 applications: ELISA Capture, ELISA Development, ELISA Development (Capture), ELISpot Development.

Showing Publications 1 - 10 of 20. Show All 20 Publications. Collapse Publications.

Publications using MAB785	Applications	Species
K Kasahara, N Sasaki, HZ Amin, T Tanaka, S Horibe, T Yamashita, KI Hirata, Y Rikitake Depletion of Foxp3+ regulatory T cells augments CD4+ T cell immune responses in atherosclerosis-prone hypercholesterolemic mice Heliyon, 2022-07-19;8(7):e09981. 2022-07-19 [PMID: 35898604] (ELISA Capture, Mouse)	ELISA Capture	Mouse
D Shin, Y Shin, E Kim, H Nam, H Nan, J Lee Immunological characteristics of MAV/06 strain of varicella-zoster virus vaccine in an animal model Oncogene, 2022-06-03;23(1):27. 2022-06-03 [PMID: 35658899] (ELISA Capture, Mouse)	ELISA Capture	Mouse
M Ramírez, S Santos, O Martínez, R Rodríguez, E Miranda, WD Ramos-Pere, M Otero Characterization of the immune response elicited by the vaccinia virus L3 protein delivered as naked DNA Vaccine, 2018-03-07;36(15):2049-2055. 2018-03-07 [PMID: 29525282] (ELISA Capture, Mouse)	ELISA Capture	Mouse
O Martínez, A Bravo Cruz, S Santos, M Ramírez, E Miranda, J Shisler, M Otero Vaccination with a codon-optimized A27L-containing plasmid decreases virus replication and dissemination after vaccinia virus challenge Vaccine, 2017-06-16;0(0):. 2017-06-16 [PMID: 28629922] (ELISA Development (Capture), Mouse)	ELISA Development (Capture)	Mouse
W Dawicki, C Li, J Town, X Zhang, JR Gordon Therapeutic reversal of food allergen sensitivity by mature retinoic acid-differentiated dendritic cell induction of LAG3(+)CD49b(-)Foxp3(-) regulatory T�cells J. Allergy Clin. Immunol., 2016-10-26;139(5):1608-1620.e3. 2016-10-26 [PMID: 28277274] (ELISA Development (Capture), Mouse)	ELISA Development (Capture)	Mouse
I Hwang, K Kim, S Choi, M Lomunova Potentiation of T Cell Stimulatory Activity by Chemical Fixation of a Weak Peptide-MHC Complex Mol. Cells, 2017-01-31;40(1):24-36. 2017-01-31 [PMID: 28152301] (ELISA Development (Capture), Mouse)	ELISA Development (Capture)	Mouse
Miljana Mom?ilovi? Tenascin-C deficiency protects mice from experimental autoimmune encephalomyelitis J. Neuroimmunol, 2016-12-07;0(0):. 2016-12-07 [PMID: 27974153] (ELISA Development (Capture), Mouse)	ELISA Development (Capture)	Mouse
Martinez O, Miranda E, Ramirez M, Santos S, Rivera C, Vazquez L, Sanchez T, Tremblay R, Rios-Olivares E, Otero M Immunomodulator-based enhancement of anti smallpox immune responses. PLoS ONE, 2015-04-13;10(4):e0123113. 2015-04-13 [PMID: 25875833] (ELISA Development (Capture), Mouse)	ELISA Development (Capture)	Mouse
Khalil S, Tonkin D, Snead A, Parks G, Johnston R, White L An alphavirus-based adjuvant enhances serum and mucosal antibodies, T cells, and protective immunity to influenza virus in neonatal mice. J Virol, 2014-06-04;88(16):9182-96. 2014-06-04 [PMID: 24899195] (ELISA Development (Capture), Mouse)	ELISA Development (Capture)	Mouse
Zhang X, Schaumburg C, Coursey T, Siemasko K, Volpe E, Gandhi N, Li D, Niederkorn J, Stern M, Pflugfelder S, de Paiva C CD8(+) cells regulate the T helper-17 response in an experimental murine model of Sjogren syndrome. Mucosal Immunol, 2013-09-11;7(2):417-27. 2013-09-11 [PMID: 24022789] (ELISA Development (Capture), Mouse)	ELISA Development (Capture)	Mouse
Costa MF, Bornstein VU, Candea AL, Henriques-Pons A, Henriques MG, Penido C CCL25 induces alpha 4 beta 7 integrin-dependent migration of IL-17+ gamma/delta T lymphocytes during an allergic reaction. Eur. J. Immunol., 2012-05-01;42(5):1250-60. 2012-05-01 [PMID: 22539297] (ELISA Development, Mouse)	ELISA Development	Mouse
Kraynyak KA, Kutzler MA, Cisper NJ, Khan AS, Draghia-Akli R, Sardesal NY, Lewis MG, Yan J, Weiner DB Systemic immunization with CCL27/CTACK modulates immune responses at mucosal sites in mice and macaques. Vaccine, 2010-02-23;28(8):1942-51. 2010-02-23 [PMID: 20188250] (ELISpot Development, Mouse)	ELISpot Development	Mouse
Lemos HP, Grespan R, Vieira SM, Cunha TM, Verri WA, Fernandes KS, Souto FO, McInnes IB, Ferreira SH, Liew FY, Cunha FQ Prostaglandin mediates IL-23/IL-17-induced neutrophil migration in inflammation by inhibiting IL-12 and IFNgamma production. Proc. Natl. Acad. Sci. U.S.A., 2009-03-16;106(14):5954-9. 2009-03-16 [PMID: 19289819] (ELISA Development, Mouse)	ELISA Development	Mouse
Wieland CW, van der Windt GJ, Florquin S, McKenzie AN, van der Poll T ST2 deficient mice display a normal host defense against pulmonary infection with Mycobacterium tuberculosis. Microbes Infect., 2009-03-13;11(4):524-30. 2009-03-13 [PMID: 19286469] (ELISA Development, Mouse)	ELISA Development	Mouse
Wieland CW, van der Windt GJ, Wiersinga WJ, Florquin S, van der Poll T CD14 contributes to pulmonary inflammation and mortality during murine tuberculosis. Immunology, 2008-04-03;125(2):272-9. 2008-04-03 [PMID: 18393969] (ELISA Development, Mouse)	ELISA Development	Mouse
Muranski P, Boni A, Antony PA, Cassard L, Irvine KR, Kaiser A, Paulos CM, Palmer DC, Touloukian CE, Ptak K, Gattinoni L, Wrzesinski C, Hinrichs CS, Kerstann KW, Feigenbaum L, Chan CC, Restifo NP Tumor-specific Th17-polarized cells eradicate large established melanoma. Blood, 2008-03-19;112(2):362-73. 2008-03-19 [PMID: 18354038] (ELISA Development, Mouse)	ELISA Development	Mouse
Chattergoon MA, Muthumani K, Tamura Y, Ramanathan M, Shames JP, Saulino V, Robinson TM, Montaner LJ, Weiner DB DR5 activation of caspase-8 induces DC maturation and immune enhancement in vivo. Mol. Ther., 2007-12-18;16(2):419-26. 2007-12-18 [PMID: 18087262] (ELISA Development, Mouse)	ELISA Development	Mouse
Watanabe H, Kubo M, Numata K, Takagi K, Mizuta H, Okada S, Ito T, Matsukawa A Overexpression of suppressor of cytokine signaling-5 in T cells augments innate immunity during septic peritonitis. J. Immunol., 2006-12-15;177(12):8650-7. 2006-12-15 [PMID: 17142765] (ELISA Development, Mouse)	ELISA Development	Mouse
Osuchowski MF, Siddiqui J, Copeland S, Remick DG Sequential ELISA to profile multiple cytokines from small volumes. J. Immunol. Methods, 2005-07-01;302(1):172-81. 2005-07-01 [PMID: 16023134] (ELISA Development, Mouse)	ELISA Development	Mouse
Quarcoo D, Schulte-Herbruggen O, Lommatzsch M, Schierhorn K, Hoyle GW, Renz H, Braun A Nerve growth factor induces increased airway inflammation via a neuropeptide-dependent mechanism in a transgenic animal model of allergic airway inflammation. Clin. Exp. Allergy, 2004-07-01;34(7):1146-51. 2004-07-01 [PMID: 15248864] (ELISA Development, Mouse)	ELISA Development	Mouse
Show All 20 Publications. Collapse Publications.

Array MAB785

• IFN-gamma Antibodies
• IFN-gamma Antibody Pairs
• IFN-gamma ELISA Kits
• IFN-gamma Kits
• IFN-gamma Lysate
• IFN-gamma Proteins
• IFN-gamma ELISAs
• IFN-gamma Proteins and Enzymes