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IFN-alpha/beta R1 Antibody [Janelia Fluor® 549]

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, IP
Clonality
Polyclonal
Host
Rabbit
Conjugate
Janelia Fluor 549

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 350
NBP2-32196AF350
Alexa Fluor 405
NBP2-32196AF405
Alexa Fluor 488
NBP2-32196AF488
Alexa Fluor 532
NBP2-32196AF532
Alexa Fluor 594
NBP2-32196AF594
Alexa Fluor 647
NBP2-32196AF647
Alexa Fluor 700
NBP2-32196AF700
Alexa Fluor 750
NBP2-32196AF750
Biotin
NBP2-32196B
DyLight 350
NBP2-32196UV
DyLight 405
NBP2-32196V
DyLight 488
NBP2-32196G
DyLight 550
NBP2-32196R
DyLight 594
NBP2-32196DL594
DyLight 650
NBP2-32196C
DyLight 680
NBP2-32196FR
DyLight 755
NBP2-32196IR
HRP
NBP2-32196H
Janelia Fluor 646
NBP2-32196JF646
Unconjugated
NBP2-32196
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IFN-alpha/beta R1 Antibody [Janelia Fluor® 549] Summary

Immunogen
The immunogen this antibody was made to, maps to a region between residue 507 to 557 of human Interferon (alpha, beta and omega) Receptor 1 using the numbering given in entry NP_000620.2 (GeneID 3454).
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
IFNAR1
Purity
Immunogen affinity purified
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Applications/Dilutions

Dilutions
  • Immunoprecipitation
  • Western Blot
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Immunogen affinity purified

Notes



Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.

Alternate Names for IFN-alpha/beta R1 Antibody [Janelia Fluor® 549]

  • alpha-type antiviral protein
  • AVP
  • beta-type antiviral protein
  • CRF2-1
  • Cytokine receptor class-II member 1
  • Cytokine receptor family 2 member 1
  • human interferon-alpha receptor (HuIFN-alpha-Rec)10IFRC
  • IFN-alpha/beta R1
  • IFN-alpha/beta receptor 1
  • IFN-alpha-REC
  • IFNAR
  • IFNAR1
  • IFN-aR1
  • IFNBR
  • IFNbR1
  • IFN-bR1
  • IFN-R-1
  • interferon (alpha, beta and omega) receptor 1
  • interferon alpha/beta receptor 1
  • interferon-alpha/beta receptor alpha chain
  • interferon-beta receptor 1
  • Type I interferon receptor 1

Background

Interferon alpha receptor 1 (IFN-alpha R1) is a class II cytokine receptor which belongs to type I human interferons (IFNs) family. IFNs plays a role in antiviral, antiproliferative, immunomodulatory, antitumor, and antiparasitic activities by inducing transcription of IFN-stimuated genes (ISGs) through activation of the Jak-STAT pathway. Specifically, IFN- R1 is a 135-kda signal transducing subunit of the IFN alpha/beta receptor complex (IFN-alpha R) (1). IFN-alpha R1 is phospholyated through PTK- and PKC-mediated phosphorylation, which initiates docking of STAT proteins to IFNs. This leads to activation of STAT proteins by PTK-mediated phosphorylation. The mechanism behind the amplification of IFN-alpha R complex mediated transmembrane signaling has been linked to tyrosine phosphorylation on IFN-alpha R1 (2).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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NBP2-32196JF549
IFN-alpha/beta R1 Antibody [Janelia Fluor® 549]
Species: Hu
Applications: WB, IP

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Bioinformatics

Gene Symbol IFNAR1