IFN-alpha/beta R1 Antibody Summary
Immunogen |
The immunogen this antibody was made to, maps to a region between residue 507 to 557 of human Interferon (alpha, beta and omega) Receptor 1 using the numbering given in entry NP_000620.2 (GeneID 3454). |
Isotype |
IgG |
Clonality |
Polyclonal |
Host |
Rabbit |
Gene |
IFNAR1 |
Purity |
Immunogen affinity purified |
Innovator's Reward |
Test in a species/application not listed above to receive a full credit towards a future purchase. |
Applications/Dilutions
Dilutions |
- Immunoprecipitation 2 - 10 ug/mg lysate
- Western Blot 1:1000 - 1:5000
|
Application Notes |
Western blot of lysates performed using standard western blot reagents and 4-20% SDS-PAGE. |
Packaging, Storage & Formulations
Storage |
Store at 4C. Do not freeze. |
Buffer |
Tris-Citrate/Phosphate (pH 7.0 - 8.0) |
Preservative |
0.09% Sodium Azide |
Concentration |
1.0 mg/ml |
Purity |
Immunogen affinity purified |
Alternate Names for IFN-alpha/beta R1 Antibody
Background
Interferon alpha receptor 1 (IFN-alpha R1) is a class II cytokine receptor which belongs to type I human interferons (IFNs) family. IFNs plays a role in antiviral, antiproliferative, immunomodulatory, antitumor, and antiparasitic activities by inducing transcription of IFN-stimuated genes (ISGs) through activation of the Jak-STAT pathway. Specifically, IFN- R1 is a 135-kda signal transducing subunit of the IFN alpha/beta receptor complex (IFN-alpha R) (1). IFN-alpha R1 is phospholyated through PTK- and PKC-mediated phosphorylation, which initiates docking of STAT proteins to IFNs. This leads to activation of STAT proteins by PTK-mediated phosphorylation. The mechanism behind the amplification of IFN-alpha R complex mediated transmembrane signaling has been linked to tyrosine phosphorylation on IFN-alpha R1 (2).
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are
guaranteed for 1 year from date of receipt.
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Secondary Antibodies
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