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ICEBERG Antibody

Images

 
Western Blot: ICEBERG Antibody [H00059082-B01P] - Analysis of CARD18 expression in transfected 293T cell line by CARD18 polyclonal antibody. Lane 1: ICEBERG transfected lysate(9.9 KDa). Lane 2: Non-transfected lysate.

Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB
Clonality
Polyclonal
Host
Mouse
Conjugate
Unconjugated

Order Details

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ICEBERG Antibody Summary

Immunogen
ICEBERG (NP_067546.1, 1 a.a. - 90 a.a.) full-length human protein. MADQLLRKKRRIFIHSVGAGTINALLDCLLEDEVISQEDMNKVRDENDTVMDKARVLIDLVTGKGPKSCCKFIKHLCEEDPQLASKMGLH
Specificity
ICEBERG - ICEBERG caspase-1 inhibitor,
Isotype
IgG
Clonality
Polyclonal
Host
Mouse
Gene
CARD18
Purity
Protein A purified
Innovator's Reward
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Applications/Dilutions

Dilutions
  • Western Blot 1:500
Application Notes
Antibody reactive against recombinant protein with GST tag on ELISA and western blot and also on transfected lysate in western blot. GST tag alone is used as a negative control.

Packaging, Storage & Formulations

Storage
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.4)
Preservative
No Preservative
Purity
Protein A purified

Notes

This product is produced by and distributed for Abnova, a company based in Taiwan.

Alternate Names for ICEBERG Antibody

  • caspase recruitment domain family, member 18
  • Caspase-1 inhibitor Iceberg
  • ICEBERG caspase-1 inhibitor
  • ICEBERGcaspase recruitment domain-containing protein 18
  • pseudo-ICE
  • UNQ5804

Background

ICEBERG, also known as Caspase recruitment domain-containing protein 18, is a 90 amino acid protein that is 10 kDa, most often expressed in the heart and placenta, down-regulates the release of IL1B, and by interacting with caspase-1 and preventing its association with RIP2 inhibits the generation of IL-1-beta. This protein is being studied for its involvement in chronic lymphocytic leukemia. The ICEBERG protein has been linked to the NOD-like receptor signaling pathway where it interacts with CASP1, CARD8, CARD16, and CARD17.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol

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Secondary Antibodies

 

Isotype Controls

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Bioinformatics

Gene Symbol CARD18
Entrez
Uniprot