Human TIMP-1 DuoSet ELISA, 15 Plate

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

TIMPs-1 through -4 regulate the activity of zinc metalloproteases known as MMPs, ADAMs and ADAMTSs. Structurally, TIMPs contain two domains. The N-terminal domain binds to the active site of mature metalloproteases via a 1:1 non-covalent interaction, blocking access of substrates to the catalytic site. In addition, The C-terminal domain of TIMP-1 and TIMP-2 binds to the hemopexin- like domain of pro-MMP-9 and pro-MMP-2, respectively. The latter binding is essential for the cell surface activation of MMP-2 by MMP-14.

We have publications tested in 1 confirmed species: Human.

Showing Publications 1 - 10 of 44. Show All 44 Publications. Collapse Publications.

Publications using DY970	Applications	Species
Almuntashiri, S;Dutta, S;Zhu, Y;Gamare, S;Ramírez, G;Irineo-Moreno, V;Camarena, A;Regino, N;Campero, P;Hernández-Cardenas, CM;Rodriguez-Reyna, TS;Zuñiga, J;Owen, CA;Wang, X;Zhang, D; Estrogen-dependent gene regulation: Molecular basis of TIMP-1 as a sex-specific biomarker for acute lung injury Physiological reports 2024-09-01 [PMID: 39267201] (Human)		Human
Zisman, D;Sabtan, H;Rahat, MM;Simanovich, E;Haddad, A;Gazitt, T;Feld, J;Slobodin, G;Kibari, A;Elias, M;Rahat, MA; Tofacitinib Regulates Endostatin via Effects on CD147 and Cathepsin S International journal of molecular sciences 2024-07-02 [PMID: 39000375] (Human)		Human
Cherpaz, M;Meugnier, E;Seillier, G;Pozzi, M;Pierrard, R;Leboube, S;Farhat, F;Vola, M;Obadia, JF;Amaz, C;Chalabreysse, L;May, C;Chanon, S;Brun, C;Givre, L;Bidaux, G;Mewton, N;Derumeaux, G;Bergerot, C;Paillard, M;Thibault, H; Myocardial transcriptomic analysis of diabetic patients with aortic stenosis: key role for mitochondrial calcium signaling Cardiovascular diabetology 2024-07-08 [PMID: 38978010] (Human)		Human
Wierzbicka-Ruci?ska, A;Kubiszewska, I;Grzywa-Czuba, R;Gackowska, L;Szalecki, M;Micha?kiewicz, J;Trojanek, JB; Implications of the Matrix Metalloproteinases, Their Tissue Inhibitors and Some Other Inflammatory Mediators Expression Levels in Children Obesity-Related Phenotypes Journal of personalized medicine 2024-03-19 [PMID: 38541059] (Human)		Human
Coufal, S;Kverka, M;Kreisinger, J;Thon, T;Rob, F;Kolar, M;Reiss, Z;Schierova, D;Kostovcikova, K;Roubalova, R;Bajer, L;Jackova, Z;Mihula, M;Drastich, P;Tresnak Hercogova, J;Novakova, M;Vasatko, M;Lukas, M;Tlaskalova-Hogenova, H;Jiraskova Zakostelska, Z; Serum TGF-?1 and CD14 Predicts Response to Anti-TNF-? Therapy in IBD Journal of immunology research 2023-06-20 [PMID: 37383609] (Human)		Human
Buchheit, T;Huh, Y;Breglio, A;Bang, S;Xu, J;Matsuoka, Y;Guo, R;Bortsov, A;Reinecke, J;Wehling, P;Jun Huang, T;Ji, RR; Intrathecal Administration of Conditioned Serum from Different Species Resolves Chemotherapy-Induced Neuropathic Pain in Mice via Secretory Exosomes Brain, behavior, and immunity 2023-05-05 [PMID: 37150265] (Human)		Human
D Abasheva, MM Dolcet-Neg, MA Fernández-, JM Mora-Gutié, J Orbe, FJ Escalada, N Garcia-Fer Association between Circulating Levels of 25-Hydroxyvitamin D3 and Matrix Metalloproteinase-10 (MMP-10) in Patients with Type 2 Diabetes Nutrients, 2022-08-24;14(17):. 2022-08-24 [PMID: 36079742] (Human)		Human
Kartasheva-Ebertz D, Gaston J, Lair-Mehiri L, Mottez E, Buivan T, Massault P, Scatton O, Gaujoux S, Vaillant J, Pol S, Lagaye S IL-17A in Human Liver: Significant Source of Inflammation and Trigger of Liver Fibrosis Initiation. Int J Mol Sci, 2022-08-29;23(17):. 2022-08-29 [PMID: 36077175] (Human)		Human
S Rutecki, P Szulc, M Paku?a, P Uruski, A Radziemski, E Naumowicz, R Moszy?ski, A Tykarski, J Miku?a-Pie, K Ksi??ek Pro-cancerogenic effects of spontaneous and drug-induced senescence of ovarian cancer cells in vitro and in vivo: a comparative analysis Journal of ovarian research, 2022-07-26;15(1):87. 2022-07-26 [PMID: 35883110] (Human)		Human
JP Lapuente, G Gómez, J Marco-Brua, P Fernández, P Desportes, J Sanz, M García-Gil, F Bermejo, JV San Martín, A Algaba, JC De Gregori, D Lapuente, A De Gregori, B Lapuente, S Gómez, MLV Andrés, A Anel Evaluation in a Cytokine Storm Model In Vivo of the Safety and Efficacy of Intravenous Administration of PRS CK STORM (Standardized Conditioned Medium Obtained by Coculture of Monocytes and Mesenchymal Stromal Cells) Biomedicines, 2022-05-08;10(5):. 2022-05-08 [PMID: 35625831] (Human)		Human
P Globig, R Madurawala, R Willumeit-, F Martini, E Mazzoni, BJC Luthringer Mg-based materials diminish tumor spreading and cancer metastases Bioactive materials, 2022-05-10;19(0):594-610. 2022-05-10 [PMID: 35600975] (Human)		Human
S Cambier, M Metzemaeke, AC Carvalho, A Nooyens, C Jacobs, L Vanderbeke, B Malengier-, M Gouwy, E Heylen, P Meersseman, G Hermans, E Wauters, A Wilmer, C Consortium, D Schols, P Matthys, G Opdenakker, RE Marques, J Wauters, J Vandooren, P Proost Atypical response to bacterial co-infection and persistent neutrophilic broncho-alveolar inflammation distinguish critical COVID-19 from influenza JCI Insight, 2022-01-11;0(0):. 2022-01-11 [PMID: 34793331] (Human)		Human
S Boumiza, K Chahed, Z Tabka, MP Jacob, X Norel, G Ozen MMPs and TIMPs levels are correlated with anthropometric parameters, blood pressure, and endothelial function in obesity Scientific Reports, 2021-10-08;11(1):20052. 2021-10-08 [PMID: 34625635] (Human)		Human
K Noda, B Dufner, H Ito, K Yoshida, G Balboni, RH Straub Differential inflammation-mediated function of prokineticin 2 in the synovial fibroblasts of patients with rheumatoid arthritis compared with osteoarthritis Scientific Reports, 2021-09-15;11(1):18399. 2021-09-15 [PMID: 34526577] (Human)		Human
Y Hosokawa, I Hosokawa, K Ozaki Nobiletin Decreases Inflammatory Mediator Expression in Tumor Necrosis Factor-Stimulated Human Periodontal Ligament Cells Mediators of Inflammation, 2021-07-10;2021(0):5535844. 2021-07-10 [PMID: 34335088] (Human)		Human
S Hong, KH Park, YE Lee, S Shin, HJ Kim, YM Kim Antibody microarray analysis of the amniotic fluid proteome�for predicting the outcome of rescue cerclage in patients with cervical insufficiency Bioscience Reports, 2021-07-30;41(7):. 2021-07-30 [PMID: 34195783] (Human)		Human
R Urbanavi?i, R Zabitait?, A Kriš?iukai, VP Deltuva, D Skiriut? Serum protein triplet TGF-&beta1, TIMP-1, and YKL-40 serve as diagnostic and prognostic profile for astrocytoma Scientific Reports, 2021-06-23;11(1):13100. 2021-06-23 [PMID: 34162919] (Human)		Human
MM Brunton-O', AS Holley, KE Hally, GA Kristono, SA Harding, PD Larsen A combined biomarker approach for characterising extracellular matrix profiles in acute myocardial infarction Scientific Reports, 2021-06-16;11(1):12705. 2021-06-16 [PMID: 34135421] (Human)		Human
C Veraar, J Kliman, A Benazzo, F Oberndorfe, M Laggner, P Hacker, T Raunegger, S Janik, P Jaksch, W Klepetko, HJ Ankersmit, B Moser Potential novel biomarkers for chronic lung allograft dysfunction and azithromycin responsive allograft dysfunction Scientific Reports, 2021-03-24;11(1):6799. 2021-03-24 [PMID: 33762606] (Human)		Human
Y Hosokawa, I Hosokawa, K Ozaki, T Matsuo The Polymethoxy Flavonoid Sudachitin Inhibits Interleukin-1&beta-Induced Inflammatory Mediator Production in Human Periodontal Ligament Cells BioMed Research International, 2021-01-28;2021(0):8826586. 2021-01-28 [PMID: 33575345] (Human)		Human
HK Pihlstrøm, T Ueland, AE Michelsen, P Aukrust, F Gatti, C Hammarströ, M Kasprzycka, J Wang, G Haraldsen, G Mjøen, DO Dahle, K Midtvedt, IA Eide, A Hartmann, H Holdaas Exploring the potential effect of paricalcitol on markers of inflammation in de novo renal transplant recipients PLoS ONE, 2020-12-16;15(12):e0243759. 2020-12-16 [PMID: 33326471] (Human)		Human
JB Trojanek, J Micha?kiew, R Grzywa-Czu, W Ja?czyk, L Gackowska, I Kubiszewsk, A Helmin-Bas, A Wierzbicka, M Szalecki, P Socha Expression of Matrix Metalloproteinases and Their Tissue Inhibitors in Peripheral Blood Leukocytes and Plasma of Children with Nonalcoholic Fatty Liver Disease Mediators Inflamm., 2020-09-10;2020(0):8327945. 2020-09-10 [PMID: 32963496] (Human)		Human
A Abbes, Y Zayani, W Zidi, MB Hammami, A Mebazaa, D El Euch, A Ben Ammar, H Sanhaji, MV El May, M Mokni, M Feki, M Allal-Elas Matrix metalloproteinase-7 could be a predictor for acute inflammation in psoriatic patients Cytokine, 2020-07-11;134(0):155195. 2020-07-11 [PMID: 32663776] (Human)		Human
CC Wu, YR Chen, DH Lu, LH Hsu, KC Yang, S Sumi Evaluation of the post-treatment anti-inflammatory capacity of osteoarthritic chondrocytes: An in�vitro study using baicalein Regen Ther, 2020-02-24;14(0):177-183. 2020-02-24 [PMID: 32128354] (Human)		Human
JM Mora-Gutié, JA Rodríguez, MA Fernández-, J Orbe, FJ Escalada, MJ Soler, MF Slon Roble, M Riera, JA Páramo, N Garcia-Fer MMP-10 is Increased in Early Stage Diabetic Kidney Disease and can be Reduced by Renin-Angiotensin System Blockade Sci Rep, 2020-01-08;10(1):26. 2020-01-08 [PMID: 31913319] (Human)		Human
YJ Park, SJ Woo, YM Kim, S Hong, YE Lee, KH Park Immune and Inflammatory Proteins in Cord Blood as Predictive Biomarkers of Retinopathy of Prematurity in Preterm Infants Invest. Ophthalmol. Vis. Sci., 2019-09-03;60(12):3813-3820. 2019-09-03 [PMID: 31525777] (Human)		Human
S Coufal, N Galanova, L Bajer, Z Gajdarova, D Schierova, Z Jiraskova, K Kostovciko, Z Jackova, Z Stehlikova, P Drastich, H Tlaskalova, M Kverka Inflammatory Bowel Disease Types Differ in Markers of Inflammation, Gut Barrier and in Specific Anti-Bacterial Response Cells, 2019-07-13;8(7):. 2019-07-13 [PMID: 31337064] (Human)		Human
R Linder, E Rönmark, J Pourazar, AF Behndig, A Blomberg, A Lindberg Proteolytic biomarkers are related to prognosis in COPD- report from a population-based cohort Respir. Res., 2018-04-12;19(1):64. 2018-04-12 [PMID: 29650051] (Human)		Human
O Prokopchuk, B Grünwald, U Nitsche, C Jäger, OL Prokopchuk, EC Schubert, H Friess, ME Martignoni, A Krüger Elevated systemic levels of the matrix metalloproteinase inhibitor TIMP-1 correlate with clinical markers of cachexia in patients with chronic pancreatitis and pancreatic cancer BMC Cancer, 2018-02-02;18(1):128. 2018-02-02 [PMID: 29394913] (Human)		Human
S Brilha, CWM Ong, B Weksler, N Romero, PO Couraud, JS Friedland Matrix metalloproteinase-9 activity and a downregulated Hedgehog pathway impair blood-brain barrier function in an in vitro model of CNS tuberculosis Sci Rep, 2017-11-22;7(1):16031. 2017-11-22 [PMID: 29167512] (Human)		Human
CW Ong, PJ Pabisiak, S Brilha, P Singh, F Roncaroli, PT Elkington, JS Friedland Complex regulation of neutrophil-derived MMP-9 secretion in central nervous system tuberculosis J Neuroinflammation, 2017-02-07;14(1):31. 2017-02-07 [PMID: 28173836] (Human)		Human
Shams-Un-Nisa Naveed MMP-1 Activation Contributes to Airway Smooth Muscle Growth and Asthma Severity Am. J. Respir. Crit. Care Med, 2017-04-15;0(0):. 2017-04-15 [PMID: 27967204] (Human)		Human
Association of Matrix Metalloproteinases -7, -8 and -9 and TIMP -1 with Disease Severity in Acute Pancreatitis. A Cohort Study PLoS ONE, 2016-08-25;11(8):e0161480. 2016-08-25 [PMID: 27561093] (Human)		Human
Linder R, Ronmark E, Pourazar J, Behndig A, Blomberg A, Lindberg A Serum metalloproteinase-9 is related to COPD severity and symptoms - cross-sectional data from a population based cohort-study. Respir Res, 2015-02-21;16(0):28. 2015-02-21 [PMID: 25849664] (Human)		Human
Rath T, Zwaschka L, Hage L, Kugler M, Menendez K, Naehrlich L, Schulz R, Roderfeld M, Roeb E Identification of neutrophil activation markers as novel surrogate markers of CF lung disease. PLoS ONE, 2014-12-29;9(12):e115847. 2014-12-29 [PMID: 25545245] (Human)		Human
Ji J, von Scheele I, Bergstrom J, Billing B, Dahlen B, Lantz A, Larsson K, Palmberg L Compartment differences of inflammatory activity in chronic obstructive pulmonary disease. Respir Res, 2014-08-26;15(0):104. 2014-08-26 [PMID: 25155252] (Human)		Human
Gomez I, Benyahia C, Louedec L, Leseche G, Jacob M, Longrois D, Norel X Decreased PGE(2) content reduces MMP-1 activity and consequently increases collagen density in human varicose vein. PLoS ONE, 2014-02-05;9(2):e88021. 2014-02-05 [PMID: 24505358] (Human)		Human
Tsai HC, Ye SY, Kunin CM, Lee SS, Wann SR, Tai MH, Shi MH, Liu YC, Chen YS Expression of matrix metalloproteinases and their tissue inhibitors in the serum and cerebrospinal fluid of patients with HIV-1 infection and syphilis or neurosyphilis. Cytokine, 2011-02-26;54(0):109-16. 2011-02-26 [PMID: 21354815] (Human)		Human
O'Kane CM, Elkington PT, Jones MD, Caviedes L, Tovar M, Gilman RH, Stamp G, Friedland JS STAT3, p38 MAPK, and NF-kappaB drive unopposed monocyte-dependent fibroblast MMP-1 secretion in tuberculosis. Am. J. Respir. Cell Mol. Biol., 2009-11-13;43(0):465. 2009-11-13 [PMID: 19915152] (Human)		Human
Shyamsundar M, McKeown ST, O'Kane CM, O'Kane CM, O'Kane CM, O'Kane CM, O'Kane CM, Craig TR, Brown V, Thickett DR, Matthay MA, Taggart CC, Backman JT, Elborn JS, McAuley DF Simvastatin decreases lipopolysaccharide-induced pulmonary inflammation in healthy volunteers. Am. J. Respir. Crit. Care Med., 2009-03-26;179(12):1107-14. 2009-03-26 [PMID: 19324974] (Human)		Human
Dietmann A, Helbok R, Lackner P, Issifou S, Lell B, Matsiegui PB, Reindl M, Schmutzhard E, Kremsner PG Matrix metalloproteinases and their tissue inhibitors (TIMPs) in Plasmodium falciparum malaria: serum levels of TIMP-1 are associated with disease severity. J. Infect. Dis., 2008-06-01;197(11):1614-20. 2008-06-01 [PMID: 18700258] (Human)		Human
Tsai HC, Chung LY, Chen ER, Sy CL Association of matrix metalloproteinase-9 and tissue inhibitors of metalloproteinase-4 in cerebrospinal fluid with blood-brain barrier dysfunction in patients with eosinophilic meningitis caused by Angiostrongylus cantonensis. Am. J. Trop. Med. Hyg., 2008-01-01;78(1):20-7. 2008-01-01 [PMID: 18187780] (Human)		Human
Lauder SN, Carty SM, Carpenter CE Interleukin-1beta induced activation of nuclear factor-kappab can be inhibited by novel pharmacological agents in osteoarthritis. Rheumatology (Oxford), 2007-01-11;46(5):752-8. 2007-01-11 [PMID: 17218328] (Human)		Human
Bergin PJ, Anders E, Sicheng W, Erik J, Jennie A, Hans L, Pierre M, Qiang PH, Marianne QJ Increased production of matrix metalloproteinases in Helicobacter pylori-associated human gastritis. Helicobacter, 2004-06-01;9(0):201. 2004-06-01 [PMID: 15165255] (Human)		Human
Show All 44 Publications. Collapse Publications.

Array DY970

• TIMP-1 Antibodies
• TIMP-1 Antibody Pair
• TIMP-1 ELISA Kits
• TIMP-1 Lysate
• TIMP-1 Protein
• TIMP-1 Proteins and Enzymes
• TIMP-1 ELISAs