Human IL-21 DuoSet ELISA, 5 Plate

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

IL-21 (Interleukin-21) is member of the family of cytokines that utilize the common gamma chain as a receptor subunit. This subunit is also a component of the receptors for IL-2, IL-4, IL-7, IL-9, and IL-15. IL-21 is produced by activated T follicular helper cells (Tfh), Th17 cells, and NKT cells. It exerts its biological effects through a heterodimeric receptor complex of the common gamma chain and the IL-21-specific IL-21 R. IL-21 supports Tfh cell development, immunoglobulin affinity maturation, plasma cell differentiation, B cell memory responses, and the migration of dendritic cells to draining lymph nodes. It costimulates the activation, proliferation, and survival of CD8+ T cells and NKT cells and promotes Th17 cell polarization. It blocks the generation of regulatory T cells and their suppressive effects on CD4+ T cells. In addition, IL-21 suppresses cutaneous hypersensitivity reactions by limiting allergen-specific IgE production and mast cell degranulation.

We have publications tested in 1 confirmed species: Human.

Showing Publications 1 - 10 of 10.

Publications using DY8879-05	Applications	Species
Chen, S;Nguyen, TD;Lee, KZ;Liu, D; Ex vivo T cell differentiation in adoptive immunotherapy manufacturing: Critical process parameters and analytical technologies Biotechnology advances 2024-08-19 [PMID: 39168355] (Human)		Human
Alipour, S;Amanallahi, P;Baradaran, B;Aghebati-Maleki, A;Soltani-Zangbar, MS;Aghebati-Maleki, L; Altered gene expression of miR-155 in peripheral blood mononuclear cells of Multiple sclerosis patients: Correlation with TH17 frequency, inflammatory cytokine profile and autoimmunity Multiple sclerosis and related disorders 2024-07-07 [PMID: 39033590] (Human)		Human
Cai, Y;Ji, H;Zhou, X;Zhao, K;Zhang, X;Pan, L;Shi, R; Interleukin-21 modulates balance between regulatory T cells and T-helper 17 cells in chronic hepatitis B virus infection BMC infectious diseases 2023-10-24 [PMID: 37875903] (Human)		Human
H Asashima, S Mohanty, M Comi, WE Ruff, KB Hoehn, P Wong, J Klein, C Lucas, I Cohen, S Coffey, N Lele, L Greta, K Raddassi, O Chaudhary, A Unterman, B Emu, SH Kleinstein, RR Montgomery, A Iwasaki, CS Dela Cruz, N Kaminski, AC Shaw, DA Hafler, TS Sumida PD-1highCXCR5-CD4+ peripheral helper T�cells promote CXCR3+ plasmablasts in human acute viral infection Cell Reports, 2023-01-02;0(0):111895. 2023-01-02 [PMID: 36596303] (Human)		Human
H Jiang, CW Wang, Z Wang, Y Dai, Y Zhu, YS Lee, Y Cao, WH Chung, S Ouyang, H Wang Functional and structural characteristics of HLA-B*13:01-mediated specific T cells reaction in dapsone-induced drug hypersensitivity Journal of Biomedical Science, 2022-08-13;29(1):58. 2022-08-13 [PMID: 35964029] (Human)		Human
A Martner, H Grauers Wi, A Törnell, J Ringlander, M Arabpour, M Lindh, M Lagging, S Nilsson, K Hellstrand Transient and durable T cell reactivity after COVID-19 Oncogene, 2022-07-12;119(30):e2203659119. 2022-07-12 [PMID: 35858456] (Human)		Human
A Rajamanick, N Pavan Kuma, AN Pandiaraj, N Selvaraj, S Munisankar, RM Renji, V Venkataram, M Murhekar, JWV Thangaraj, SK Muthusamy, GK Chethrapil, T Bhatnagar, M Ponnaiah, S Ramasamy, S Velusamy, S Babu Characterization of memory T cell subsets and common gamma-chain cytokines in convalescent COVID-19 individuals Journal of leukocyte biology, 2022-03-08;0(0):. 2022-03-08 [PMID: 35258122] (Human)		Human
M Paccagnell, A Abbona, A Michelotti, E Geuna, F Ruatta, E Landucci, N Denaro, P Vanella, C Lo Nigro, D Galizia, M Merlano, O Garrone Circulating Cytokines in Metastatic Breast Cancer Patients Select Different Prognostic Groups and Patients Who Might Benefit from Treatment beyond Progression Vaccines, 2022-01-05;10(1):. 2022-01-05 [PMID: 35062739] (Human)		Human
Y Hao, L Xie, J Xia, Z Liu, B Yang, M Zhang Plasma interleukin-21 levels and genetic variants are associated with susceptibility to rheumatoid arthritis Bmc Musculoskeletal Disorders, 2021-03-05;22(1):246. 2021-03-05 [PMID: 33673829] (Human)		Human
W Xu, M Ren, S Ghosh, K Qian, Z Luo, A Zhang, C Zhang, J Cui Defects of CTLA-4 Are Associated with Regulatory T Cells in Myasthenia Gravis Implicated by Intravenous Immunoglobulin Therapy Mediators Inflamm., 2020-02-14;2020(0):3645157. 2020-02-14 [PMID: 32148437] (Human)		Human

Array DY8879-05

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