Human IL-13 R alpha 2 DuoSet ELISA, 15 Plate

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Two members of the type 5 subfamily of type I cytokine receptors can serve as receptors for IL-13. IL-13 can bind to IL-13 R alpha 1 (CD213a1; previously designated IL-13 R alpha or NR4) with low affinity, then recruits the IL-4 R alpha chain to form a high affinity receptor, causing downstream STAT6 activation. Alternately, IL-13 can bind IL-13 R alpha 2 (CD213a2) with high affinity; this interaction does not cause activation of STAT6, but does induce TGF-beta production. IL-13 R alpha 1 and IL-13 R alpha 2 each have three extracellular fibronectin type III domains, two cytokine receptor homology modules and a WSXWS motif typical of the class I cytokine receptor family, but IL-13 R alpha 2 has a much shorter cytoplasmic tail. IL-13 R subunits can be expressed on monocytes, macrophages, fibroblasts, human B cells, basophils, eosinophils, endothelial cells, and smooth muscle cells.

We have publications tested in 1 confirmed species: Human.

Showing Publications 1 - 5 of 5.

Publications using DY614	Applications	Species
D Keresztes, A Csizmarik, N Nagy, O Módos, T Fazekas, T Bracht, B Sitek, K Witzke, M Puhr, S Sevcenco, G Kramer, S Shariat, Z Küronya, L Takács, I Tornyi, J Lázár, B Hadaschik, A Lászik, M Sz?cs, P Nyirády, T Szarvas Comparative proteome analysis identified CD44 as a possible serum marker for docetaxel resistance in castration-resistant prostate cancer Journal of Cellular and Molecular Medicine, 2021-12-30;0(0):. 2021-12-30 [PMID: 34970839] (Human)		Human
O'Toole M, Legault H, Ramsey R, Wynn TA, Kasaian MT A novel and sensitive ELISA reveals that the soluble form of IL-13R-alpha2 is not expressed in plasma of healthy or asthmatic subjects. Clin. Exp. Allergy, 2008-02-25;38(4):594-601. 2008-02-25 [PMID: 18307523] (Human)		Human
Matsumura M, Inoue H, Matsumoto T, Nakano T, Fukuyama S, Matsumoto K, Takayama K, Saito M, Kawakami K, Nakanishi Y Endogenous metalloprotease solubilizes IL-13 receptor alpha2 in airway epithelial cells. Biochem. Biophys. Res. Commun., 2007-06-19;360(2):464-9. 2007-06-19 [PMID: 17603012] (Human)		Human
Daines MO, Chen W, Tabata Y, Walker BA, Gibson AM, Masino JA, Warrier MR, Daines CL, Wenzel SE, Hershey GK Allergen-dependent solubilization of IL-13 receptor alpha2 reveals a novel mechanism to regulate allergy. J. Allergy Clin. Immunol., 2006-11-30;119(2):375-83. 2006-11-30 [PMID: 17140645] (Human)		Human
Daines MO, Tabata Y, Walker BA, Chen W, Warrier MR, Basu S, Hershey GK Level of expression of IL-13R alpha 2 impacts receptor distribution and IL-13 signaling. J. Immunol., 2006-06-15;176(12):7495-501. 2006-06-15 [PMID: 16751396] (Human)		Human

Array DY614

• IL-13R alpha 2 Antibodies
• IL-13R alpha 2 ELISA Kits
• IL-13R alpha 2 Lysate
• IL-13R alpha 2 Proteins
• IL-13R alpha 2 Proteins and Enzymes
• IL-13R alpha 2 ELISAs