Human FGF acidic/FGF1 Quantikine ELISA Kit

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

FGF acidic, also known as FGF-1, ECGF, and HBGF-1, is a secreted mitogen that stimulates the proliferation of all cells of mesodermal origin and many cells of neuroectodermal, ectodermal, and endodermal origin. It plays a number of roles in development, regeneration, and angiogenesis. FGF acidic is released extracellularly as a disulfide-linked homodimer and is stored in complex with extracellular heparan sulfate. The association of FGF acidic with heparan sulfate is a prerequisite for its subsequent interaction with FGF receptors. Internalized FGF acidic can translocate to the cytosol and to the nucleus. Intracellular FGF acidic functions as a survival factor by inhibiting p53 activity and proapoptotic signaling.

We have publications tested in 1 confirmed species: Human.

Showing Publications 1 - 9 of 9.

Publications using DFA00B	Applications	Species
C Eggermont, P Giron, M Noeparast, H Vandenplas, P Aza-Blanc, GJ Gutierrez, J De Grève The EGFR-STYK1-FGF1 axis sustains functional drug tolerance to EGFR inhibitors in EGFR-mutant non-small cell lung cancer Oncogene, 2022-07-15;13(7):611. 2022-07-15 [PMID: 35840561] (Human)		Human
Q Hui, R Yang, C Lu, J Bi, L Li, J Gong, L Zhang, Z Jin, X Li, X Wang Validation of a Double-Sandwich Enzyme-Linked Immunoassay for Pharmacokinetic Study of an rh-aFGF Hydrogel in Rat Skin and Serum Front Pharmacol, 2020-05-19;11(0):700. 2020-05-19 [PMID: 32508643] (Human)		Human
EK Day, NG Sosale, A Xiao, Q Zhong, B Purow, MJ Lazzara Glioblastoma Cell Resistance to EGFR and MET Inhibition Can Be Overcome via Blockade of FGFR-SPRY2 Bypass Signaling Cell Rep, 2020-03-10;30(10):3383-3396.e7. 2020-03-10 [PMID: 32160544] (Human)		Human
Individuality in FGF1 expression significantly influences platinum resistance and progression-free survival in ovarian cancer. Br. J. Cancer, 2012-09-18;107(8):1327-36. 2012-09-18 [PMID: 22990650] (Human)		Human
Sherman JA, Hall A, Malenka DJ, De Muinck ED, Simons M Humoral and cellular factors responsible for coronary collateral formation. Am. J. Cardiol., 2006-08-31;98(9):1194-7. 2006-08-31 [PMID: 17056326] (Human)		Human
Beck LA, Tancowny B, Brummet ME, Asaki SY, Curry SL, Penno MB, Foster M, Bahl A, Stellato C Functional analysis of the chemokine receptor CCR3 on airway epithelial cells. J. Immunol., 2006-09-01;177(5):3344-54. 2006-09-01 [PMID: 16920975] (Human)		Human
Herrmann S, Green J, Weber T, Scharfenberger A Quantitative assessment of growth factors in reaming aspirate, iliac crest, and platelet preparation. Bone, 2006-07-25;39(5):1156-63. 2006-07-25 [PMID: 16863704] (Human)		Human
Numasaki M, Watanabe M, Suzuki T, Takahashi H, Nakamura A, McAllister F, Hishinuma T, Goto J, Lotze MT, Kolls JK, Sasaki H IL-17 enhances the net angiogenic activity and in vivo growth of human non-small cell lung cancer in SCID mice through promoting CXCR-2-dependent angiogenesis. J. Immunol., 2005-11-01;175(9):6177-89. 2005-11-01 [PMID: 16237115] (Human)		Human
Stapelberg M, Gellert N, Swettenham E, Tomasetti M, Witting PK, Procopio A, Neuzil J Alpha-tocopheryl succinate inhibits malignant mesothelioma by disrupting the fibroblast growth factor autocrine loop: mechanism and the role of oxidative stress. J. Biol. Chem., 2005-05-05;280(27):25369-76. 2005-05-05 [PMID: 15878867] (Human)		Human

Array DFA00B

• FGF acidic/FGF1 Antibodies
• FGF acidic/FGF1 ELISA Kits
• FGF acidic/FGF1 Lysates
• FGF acidic/FGF1 Proteins
• FGF acidic/FGF1 Proteins and Enzymes
• FGF acidic/FGF1 ELISAs