Human Chitinase 3-like 1/YKL-40 Quantikine ELISA Kit

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Chitinase 3-like 1 (CHI3L1), also called BRP39 in mouse or YKL-40 in humans, is a 39 kDa glycoprotein member of the glycosyl hydrolase 18 family although it does not show chitotriosidase activity. CHI3L1 is expressed by articular chondrocytes, synovial cells, activated monocyte-derived macrophages, neutrophils, endothelial cells, vascular smooth muscle cells, and some cancer cells. CHI3L1 binds to chitin and heparins, and it enhances cell adhesion, proliferation and tumor angiogenesis. Circulating CHI3L1 is elevated during inflammation and connective tissue remodeling such as arthritis, chronic obstructive pulmonary disease, diabetes, cardiovascular disease, inflammatory bowel disease, and liver cirrhosis. It is frequently upregulated in glioblastoma, myxoid chondrosarcoma, melanoma and carcinomas of the breast, thyroid, colon, lung, kidney, and ovary.

We have publications tested in 1 confirmed species: Human.

Showing Publications 1 - 10 of 37. Show All 37 Publications. Collapse Publications.

Publications using DC3L10	Applications	Species
Ropri, AS;Lam, TG;Kalia, V;Buchanan, HM;Bartosch, AMW;Youth, EHH;Xiao, H;Ross, SK;Jain, A;Chakrabarty, JK;Kang, MS;Boyett, D;Spinazzi, EF;Iodice, G;McGovern, RA;Honig, LS;Brown, LM;Miller, GW;McKhann, GM;Teich, AF; Alzheimer's disease CSF biomarkers correlate with early pathology and alterations in neuronal and glial gene expression medRxiv : the preprint server for health sciences 2024-06-13 [PMID: 38947015] (Human)		Human
Shanks, HRC;Chen, K;Reiman, EM;Blennow, K;Cummings, JL;Massa, SM;Longo, FM;Börjesson-Hanson, A;Windisch, M;Schmitz, TW; p75 neurotrophin receptor modulation in mild to moderate Alzheimer disease: a randomized, placebo-controlled phase 2a trial Nature medicine 2024-05-17 [PMID: 38760589] (Human)		Human
M Babi? Leko, M Mihel?i?, J Jurasovi?, M Nikolac Pe, E Špani?, A Sekovani?, T Orct, K Zub?i?, L Langer Hor, N Plei?, S Ki?emet-Pi, Ž Vogrinc, N Pivac, A Diana, F Borove?ki, PR Hof, G Šimi? Heavy Metals and Essential Metals Are Associated with Cerebrospinal Fluid Biomarkers of Alzheimer's Disease International Journal of Molecular Sciences, 2022-12-27;24(1):. 2022-12-27 [PMID: 36613911] (Human)		Human
T Xu, K Zhang, C Zhong, Z Zhu, X Zheng, P Yang, B Che, Y Lu, Y Zhang Plasma Human Cartilage Glycoprotein-39 Is Associated With the Prognosis of Acute Ischemic Stroke Journal of the American Heart Association, 2022-09-14;0(0):e026263. 2022-09-14 [PMID: 36102255] (Human)		Human
A Huss, A Abdelhak, B Mayer, H Tumani, HP Müller, K Althaus, J Kassubek, M Otto, AC Ludolph, D Yilmazer-H, H Neugebauer Association of Serum GFAP with Functional and Neurocognitive Outcome in Sporadic Small Vessel Disease Biomedicines, 2022-08-02;10(8):. 2022-08-02 [PMID: 36009416] (Human)		Human
BF Vahsen, E Gray, A Candalija, KML Cramb, J Scaber, R Dafinca, A Katsikoudi, Y Xu, L Farrimond, R Wade-Marti, WS James, MR Turner, SA Cowley, K Talbot Human iPSC co-culture model to investigate the interaction between microglia and motor neurons Scientific Reports, 2022-07-23;12(1):12606. 2022-07-23 [PMID: 35871163] (Human)		Human
W Francuzik, K Pažur, M Dalke, S Dölle-Bier, M Babina, M Worm Serological profiling reveals hsa-miR-451a as a possible biomarker of anaphylaxis JCI Insight, 2022-04-08;0(0):. 2022-04-08 [PMID: 35202004] (Human)		Human
N Komabashir, F Suehiro, M Ishii, M Nishimura Efficacy of chitinase-3-like protein 1 as an in�vivo bone formation predictable marker of maxillary/mandibular bone marrow stromal cells Regenerative Therapy, 2021-03-27;18(0):38-50. 2021-03-27 [PMID: 33869686] (Human)		Human
PW Ko, HW Lee, M Lee, YC Youn, S Kim, JH Kim, K Kang, K Suk Increased plasma levels of chitinase 3-like 1 (CHI3L1) protein in patients with idiopathic normal-pressure hydrocephalus Journal of the neurological sciences, 2021-02-20;423(0):117353. 2021-02-20 [PMID: 33652290] (Human)		Human
Y Lee, E Lee, DK Yon, HM Jee, HS Baek, SW Lee, JY Cho, MY Han The potential pathways underlying the association of propyl-paraben exposure with aeroallergen sensitization and EASI score using metabolomics analysis Scientific Reports, 2021-02-12;11(1):3772. 2021-02-12 [PMID: 33580129] (Human)		Human
T Robinson, A Abdelhak, T Bose, E Meinl, M Otto, UK Zettl, R Dersch, H Tumani, S Rauer, A Huss Cerebrospinal Fluid Biomarkers in Relation to MRZ Reaction Status in Primary Progressive Multiple Sclerosis Cells, 2020-11-25;9(12):. 2020-11-25 [PMID: 33255854] (Human)		Human
Y Kwon, JH Kim, EK Ha, HM Jee, HS Baek, MY Han, SJ Jeong Serum YKL-40 Levels Are Associated with the Atherogenic Index of Plasma in Children Mediators Inflamm, 2020-09-26;2020(0):8713908. 2020-09-26 [PMID: 33061832] (Human)		Human
MA Gomez-Llor, A Martínez-C, N Chueca, MC Rico, R Romero, A Anguita-Ru, CM Aguilera, M Gil-Campos, MD Mesa, B Khakimov, JA Morillo, Á Gil, J Camacho, C Gomez-Llor A Multi-Omics Approach Reveals New Signatures in Obese Allergic Asthmatic Children Biomedicines, 2020-09-18;8(9):. 2020-09-18 [PMID: 32961859] (Human)		Human
G Ye, Z Xie, H Zeng, P Wang, J Li, G Zheng, S Wang, Q Cao, M Li, W Liu, S Cen, Z Li, Y Wu, Z Ye, H Shen Oxidative stress-mediated mitochondrial dysfunction facilitates mesenchymal stem cell senescence in ankylosing spondylitis Cell Death Dis, 2020-09-17;11(9):775. 2020-09-17 [PMID: 32943613] (Human)		Human
UD Teitsdotti, MK Jonsdottir, SH Lund, T Darreh-Sho, J Snaedal, PH Petersen Association of glial and neuronal degeneration markers with Alzheimer's disease cerebrospinal fluid profile and cognitive functions Alzheimers Res Ther, 2020-08-04;12(1):92. 2020-08-04 [PMID: 32753068] (Human)		Human
T Shirai, K Hirai, Y Gon, S Maruoka, K Mizumura, M Hikichi, K Itoh, S Hashimoto Combined assessment of serum eosinophil-derived neurotoxin and YKL-40 may identify Asthma-COPD overlap Allergol Int, 2020-06-20;0(0):. 2020-06-20 [PMID: 32571644] (Human)		Human
P Kušnierová, D Zeman, P Hradílek, O Zapletalov, D Stejskal Determination of chitinase 3-like 1 in cerebrospinal fluid in multiple sclerosis and other neurological diseases PLoS ONE, 2020-05-21;15(5):e0233519. 2020-05-21 [PMID: 32437412] (Human)		Human
EA Hoste, ST Vaara, J De Loor, M Haapio, L Nuytinck, K Demeyere, V Pettilä, E Meyer Urinary cell cycle arrest biomarkers and chitinase 3-like protein 1 (CHI3L1) to detect acute kidney injury in the critically ill: a post hoc laboratory analysis on the FINNAKI cohort Crit Care, 2020-04-10;24(1):144. 2020-04-10 [PMID: 32276601] (Human)		Human
HJ Whitwell, J Worthingto, O Blyuss, A Gentry-Mah, A Ryan, R Gunu, J Kalsi, U Menon, I Jacobs, A Zaikin, JF Timms Improved early detection of ovarian cancer using longitudinal multimarker models Br. J. Cancer, 2020-01-15;0(0):. 2020-01-15 [PMID: 31937926] (Human)		Human
S Palmqvist, PS Insel, E Stomrud, S Janelidze, H Zetterberg, B Brix, U Eichenlaub, JL Dage, X Chai, K Blennow, N Mattsson, O Hansson Cerebrospinal fluid and plasma biomarker trajectories with increasing amyloid deposition in Alzheimer's disease EMBO Mol Med, 2019-11-11;0(0):e11170. 2019-11-11 [PMID: 31709776] (Human)		Human
H Lowes, A Pyle, M Duddy, G Hudson Cell-free mitochondrial DNA in progressive multiple sclerosis Mitochondrion, 2018-08-08;0(0):. 2018-08-08 [PMID: 30098422] (Human)		Human
M Olsson, J Ärlig, J Hedner, K Blennow, H Zetterberg Sleep Deprivation and CSF Biomarkers for Alzheimer Disease Sleep, 2018-05-01;0(0):. 2018-05-01 [PMID: 29425372] (Human)		Human
CS Jensen, E Portelius, P Høgh, L Wermuth, K Blennow, H Zetterberg, SG Hasselbalc, AH Simonsen Effect of physical exercise on markers of neuronal dysfunction in cerebrospinal fluid in patients with Alzheimer's disease Alzheimers Dement (N Y), 2017-04-17;3(2):284-290. 2017-04-17 [PMID: 29067334] (Human)		Human
A Pikwer, M Castegren, S Namdar, K Blennow, H Zetterberg, N Mattsson Effects of surgery and propofol-remifentanil total intravenous anesthesia on cerebrospinal fluid biomarkers of inflammation, Alzheimer's disease, and neuronal injury in humans: a cohort study J Neuroinflammation, 2017-09-29;14(1):193. 2017-09-29 [PMID: 28962579] (Human)		Human
J Salomon, ? Matusiak, D Nowicka-Su, JC Szepietows Chitinase-3-Like Protein 1 (YKL-40) Is a New Biomarker of Inflammation in Psoriasis Mediators Inflamm., 2017-08-28;2017(0):9538451. 2017-08-28 [PMID: 28932021] (Human)		Human
J Salomon, ? Matusiak, D Nowicka-Su, JC Szepietows Chitinase-3-Like Protein 1 (YKL-40) Reflects the Severity of Symptoms in Atopic Dermatitis J Immunol Res, 2017-06-04;2017(0):5746031. 2017-06-04 [PMID: 28660216] (Human)		Human
P Jørgen Jen, L Østergaard, JM Czarna Bah, S Modvig, K Fog, A Holm, B Rahbek Kor, S Gammeltoft Cerebrospinal Fluid Biomarkers of Neurodegeneration Are Decreased or Normal in Narcolepsy Sleep, 2017-01-01;40(1):. 2017-01-01 [PMID: 28364448] (Human)		Human
SR Langley, K Willeit, A Didangelos, LP Matic, P Skroblin, J Barallobre, M Lengquist, G Rungger, A Kapustin, L Kedenko, C Molenaar, R Lu, T Barwari, G Suna, X Yin, B Iglseder, B Paulweber, P Willeit, J Shalhoub, G Pasterkamp, AH Davies, C Monaco, U Hedin, CM Shanahan, J Willeit, S Kiechl, M Mayr Extracellular matrix proteomics identifies molecular signature of symptomatic carotid plaques J. Clin. Invest, 2017-03-20;0(0):. 2017-03-20 [PMID: 28319050] (Human)		Human
J De Loor, I Herck, K Francois, A Van Wesema, L Nuytinck, E Meyer, EA Hoste Diagnosis of cardiac surgery-associated acute kidney injury: differential roles of creatinine, chitinase 3-like protein 1 and neutrophil gelatinase-associated lipocalin: a prospective cohort study Ann Intensive Care, 2017-03-01;7(1):24. 2017-03-01 [PMID: 28251598] (Human)		Human
Viktoria Johansson Cerebrospinal fluid microglia and neurodegenerative markers in twins concordant and discordant for psychotic disorders Eur Arch Psychiatry Clin Neurosci, 2016-12-30;0(0):. 2016-12-30 [PMID: 28039552] (Human)		Human
Development of an in vitro human liver system for interrogating nonalcoholic steatohepatitis JCI Insight, 2016-12-08;1(20):e90954. 2016-12-08 [PMID: 27942596] (Human)		Human
Least absolute shrinkage and selection operator type methods for the identification of serum biomarkers of overweight and obesity: simulation and application BMC Med Res Methodol, 2016-11-14;16(1):154. 2016-11-14 [PMID: 27842498] (Human)		Human
Annette Eyking MiR-205 and MiR-373 Are Associated with Aggressive Human Mucinous Colorectal Cancer PLoS ONE, 2016-06-06;11(6):e0156871. 2016-06-06 [PMID: 27271572] (Human)		Human
Fantino E, Gangell C, Hartl D, Sly P Airway, but not serum or urinary, levels of YKL-40 reflect inflammation in early cystic fibrosis lung disease. BMC Pulm Med, 2014-02-27;14(0):28. 2014-02-27 [PMID: 24576297] (Human)		Human
Yan , Cong, Ding , Xinchun, Wu , Lingyan, Yu , Menggang, Qu , Peng, Du , Hong Stat3 downstream gene product chitinase 3-like 1 is a potential biomarker of inflammation-induced lung cancer in multiple mouse lung tumor models and humans. PLoS ONE, 2013-04-22;8(4):e61984. 2013-04-22 [PMID: 23613996] (Human)		Human
Kim HR, Jun CD, Lee KS, Cho JH, Jeong ET, Yang SH, Lee YJ, Park DS Levels of YKL-40 in pleural effusions and blood from patients with pulmonary or pleural disease. Cytokine, 2012-04-03;58(3):336-43. 2012-04-03 [PMID: 22480951] (Human)		Human
Hector A, Kormann MS, Mack I, Latzin P, Casaulta C, Kieninger E, Zhou Z, Yildirim AÖ, Bohla A, Rieber N, Kappler M, Koller B, Eber E, Eickmeier O, Zielen S, Eickelberg O, Griese M, Mall MA, Hartl D The chitinase-like protein YKL-40 modulates cystic fibrosis lung disease. PLoS ONE, 2011-09-20;6(9):e24399. 2011-09-20 [PMID: 21949714] (Human)		Human
Show All 37 Publications. Collapse Publications.

Array DC3L10

• Chitinase 3-like 1/YKL-40 Antibodies
• Chitinase 3-like 1/YKL-40 Lysate
• Chitinase 3-like 1/YKL-40 Protein
• Chitinase 3-like 1/YKL-40 ELISAs
• Chitinase 3-like 1/YKL-40 Proteins and Enzymes