Name: HTRA1/PRSS11 Antibody (275615) [Unconjugated]
Brand: Novus Biologicals
SKU: MAB2916
Price: 449 USD

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At	=	A. thaliana	SyHa	=	Golden Syrian Hamster
All	=	All Species	Ha	=	Hamster
An	=	Animal	Hu	=	Human
ArHa	=	Armenian Hamster	I	=	Insect
Av	=	Avian	Ll	=	Llama
Bb	=	Baboon	Ma	=	Mammal
Ba	=	Bacteria	Mk	=	Monkey
Bv	=	Bovine	Mu	=	Mouse
Ca	=	Canine	Multi	=	Multi-species
Ce	=	C. Elegans	NA	=	Non-species specific
Ch	=	Chicken	Or	=	Orangutan
ChHa	=	Chinese Hamster	Pl	=	Plant
Cm	=	Cynomolgus Monkey	Pm	=	Primate
Do	=	Donkey	Po	=	Porcine
Dr	=	Drosophilia	Rb	=	Rabbit
Ec	=	E. Coli	Rt	=	Rat
Eq	=	Equine	RM	=	Rhesus Macaque
Fe	=	Feline	Sh	=	Sheep
Ft	=	Ferret	Vb	=	Vertebrate
Fi	=	Fish	Vi	=	Virus
Fu	=	Fungi	Xp	=	Xenopus
Ge	=	Gerbil	Ye	=	Yeast
GP	=	Guinea Pig	Ze	=	Zebrafish
Gt	=	Goat

Reactivity	HuSpecies Glossary
Applications	WB, IP
Clone	275615
Clonality	Monoclonal
Host	Mouse
Conjugate	Unconjugated
Concentration	LYOPH

Immunogen	Mouse myeloma cell line NS0-derived recombinant human HTRA1/PRSS11 Gln23-Pro480 Accession # Q92743
Specificity	Detects human HTRA1/PRSS11 in direct ELISAs and Western blots.
Source	N/A
Isotype	IgG2b
Clonality	Monoclonal
Host	Mouse
Gene	HTRA1
Purity Statement	Protein A or G purified from hybridoma culture supernatant
Innovator's Reward	Test in a species/application not listed above to receive a full credit towards a future purchase. Learn about the Innovator's Reward

Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer	Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Preservative	No Preservative
Concentration	LYOPH
Reconstitution Instructions	Reconstitute at 0.5 mg/mL in sterile PBS.

Publications using MAB2916	Applications	Species
Navneet, S;Ishii, M;Rohrer, B; Altered Elastin Turnover, Immune Response, and Age-Related Retinal Thinning in a Transgenic Mouse Model With RPE-Specific HTRA1 Overexpression Investigative ophthalmology & visual science 2024-07-01 [PMID: 39028977] (Immunohistochemistry, Transgenic Mouse)	Immunohistochemistry	Transgenic Mouse
Beaufort, N;Ingendahl, L;Merdanovic, M;Schmidt, A;Podlesainski, D;Richter, T;Neumann, T;Kuszner, M;Vetter, IR;Stege, P;Burston, SG;Filipovic, A;Ruiz-Blanco, YB;Bravo-Rodriguez, K;Mieres-Perez, J;Beuck, C;Uebel, S;Zobawa, M;Schillinger, J;Malik, R;Todorov-Völgyi, K;Rey, J;Roberti, A;Hagemeier, B;Wefers, B;Müller, SA;Wurst, W;Sanchez-Garcia, E;Zimmermann, A;Hu, XY;Clausen, T;Huber, R;Lichtenthaler, SF;Schmuck, C;Giese, M;Kaiser, M;Ehrmann, M;Dichgans, M; Rational correction of pathogenic conformational defects in HTRA1 Nature communications 2024-07-16 [PMID: 39013852] (Western Blot, Mouse)	Western Blot	Mouse
Kouri, AM;Caza, TN;Beck, LH;Misurac, JM;Evans, MD;Phillips, CL;Eadon, MT;Larsen, CP;Andreoli, SP;Bu, L;Rheault, MN;Khalid, M; Clinical and Histopathologic Characteristics of Pediatric Patients With Primary Membranous Nephropathy Kidney international reports 2023-11-01 [PMID: 38025223] (IHC, Human)	IHC	Human
D Inoue, GL Chew, B Liu, BC Michel, J Pangallo, AR D'Avino, T Hitchman, K North, SC Lee, L Bitner, A Block, AR Moore, A Yoshimi, L Escobar-Ho, H Cho, A Penson, SX Lu, J Taylor, Y Chen, C Kadoch, O Abdel-Waha, RK Bradley Spliceosomal disruption of the non-canonical BAF complex in cancer Nature, 2019-10-09;0(0):. 2019-10-09 [PMID: 31597964] (Western Blot, Mouse)	Western Blot	Mouse
DC Hondius, KN Eigenhuis, THJ Morrema, RC van der Sc, P van Nierop, M Bugiani, KW Li, JJM Hoozemans, AB Smit, AJM Rozemuller Proteomics analysis identifies new markers associated with capillary cerebral amyloid angiopathy in Alzheimer's disease Acta Neuropathol Commun, 2018-06-04;6(1):46. 2018-06-04 [PMID: 29860944] (IHC, Human)	IHC	Human
S Yamawaki, M Naitoh, H Kubota, R Aya, Y Katayama, T Ishiko, T Tamura, K Yoshikawa, T Enoshiri, M Ikeda, S Suzuki HtrA1 Is Specifically Up-Regulated in Active Keloid Lesions and Stimulates Keloid Development Int J Mol Sci, 2018-04-24;19(5):. 2018-04-24 [PMID: 29695130] (Western Blot, Human)	Western Blot	Human
O Globus, T Evron, M Caspi, R Siman-Tov, R Rosin-Arbe High-Temperature Requirement A1 (Htra1) - A Novel Regulator of Canonical Wnt Signaling Sci Rep, 2017-12-21;7(1):17995. 2017-12-21 [PMID: 29269789] (Western Blot, Human)	Western Blot	Human
E Melo, P Oertle, C Trepp, H Meisterman, T Burgoyne, L Sborgi, AC Cabrera, CY Chen, JC Hoflack, T Kam-Thong, R Schmucki, L Badi, N Flint, ZE Ghiani, F Delobel, C Stucki, G Gromo, A Einhaus, B Hornsperge, S Golling, J Siebourg-P, F Gerber, B Bohrmann, C Futter, T Dunkley, S Hiller, O Schilling, V Enzmann, S Fauser, M Plodinec, R Iacone HtrA1 Mediated Intracellular Effects on Tubulin Using a Polarized RPE Disease Model EBioMedicine, 2017-12-13;0(0):. 2017-12-13 [PMID: 29269042] (Immunoprecipitation, Mouse)	Immunoprecipitation	Mouse
Chi Pui Pang Protective effects of an HTRA1 insertion-deletion variant against age-related macular degeneration in the Chinese populations Lab. Invest., 2016-11-14;0(0):. 2016-11-14 [PMID: 27841854] (ICC, Western Blot, Human)	ICC, Western Blot	Human
Tsz Kin Ng HTRA1 promoter variant differentiates polypoidal choroidal vasculopathy from exudative age-related macular degeneration Sci Rep, 2016-06-24;6(0):28639. 2016-06-24 [PMID: 27338780] (Western Blot, Human)	Western Blot	Human
Jo , Hakryul, Patterson , Victoria, Stoessel , Sean, Kuan , Chia-Yi, Hoh , Josephin Protoporphyrins enhance oligomerization and enzymatic activity of HtrA1 serine protease. PLoS ONE, 2014-12-15;9(12):e115362. 2014-12-15 [PMID: 25506911] (Western Blot, Human)	Western Blot	Human
Kumar , Sandeep, Berriochoa , Zachary, Ambati , Balamura, Fu , Yingbin Angiographic features of transgenic mice with increased expression of human serine protease HTRA1 in retinal pigment epithelium. Invest Ophthalmol Vis Sci, 2014-05-22;55(6):3842-50. 2014-05-22 [PMID: 24854852] (IHC, Western Blot, Mouse)	IHC, Western Blot	Mouse
Jacobo , Sarah Me, Deangelis , Margaret, Kim , Ivana K, Kazlauskas , Andrius Age-related macular degeneration-associated silent polymorphisms in HtrA1 impair its ability to antagonize insulin-like growth factor 1. Mol Cell Biol, 2013-03-11;33(10):1976-90. 2013-03-11 [PMID: 23478260] (Immunoprecipitation, Human)	Immunoprecipitation	Human
Wang N, Eckert KA, Zomorrodi AR Down-Regulation of HtrA1 Activates the Epithelial-Mesenchymal Transition and ATM DNA Damage Response Pathways. PLoS ONE, 2012-06-26;7(6):e39446. 2012-06-26 [PMID: 22761798] (Western Blot, Human)	Western Blot	Human
Mauney J, Olsen BR, Volloch V Matrix remodeling as stem cell recruitment event: a novel in vitro model for homing of human bone marrow stromal cells to the site of injury shows crucial role of extracellular collagen matrix. Matrix Biol., 2010-09-07;29(8):657-63. 2010-09-07 [PMID: 20828613] (Immunoprecipitation, Human)	Immunoprecipitation	Human
Show All 15 Publications. Collapse Publications.

HTRA1/PRSS11 Antibody (275615) [Unconjugated]

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Catalog# & Formulation	Size	Price
Carrier Free MAB2916-SP

Gene Symbol	HTRA1
Uniprot	Q92743()