Mouse HMGB1/HMG-1 ELISA Kit (Colorimetric)

HMGB1 and HMGB2 are part of the chromatin non-histone high mobility group proteins 1 and 2. HMGB1 and HMGB2 (containing multiple HMG-boxes) are conserved domains of 80 amino acids which mediate the DNA binding of many proteins. HMG box domains recognize DNA structure. Both HMGB1 and HMGB2 contain a N-terminal HMG box, a central HMG box, and an acidic carboxy terminus. The acidic tails of HMGB1 and HMGB2 contain multiple serine residues which match the phosphorylation consensus sites of casein kinase II, and phosphorylation of this domain appears to be important for proper functioning of these proteins. HMGB1 and HMGB2 have been shown to facilitate the binding of various sequence-specific transcription factors to their respective DNA binding sites. HMGB1 and HMGB2 may also serve as architectural factors that recognize and mediate DNA structural changes that accompany various events such as DNA repair, transcription, and replication.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. ELISA Kits are guaranteed for 6 months from date of receipt.

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 1 application: ELISA.

Showing Publications 1 - 10 of 10.

Publications using NBP2-62767	Applications	Species
Koutsodendris N, Blumenfeld J, Agrawal A et al. APOE4-promoted gliosis and degeneration in tauopathy are ameliorated by pharmacological inhibition of HMGB1 release Cell reports 2023-10-31 [PMID: 37863057] Details: Biochemically extracted mouse hippocampal tissue lysates or collected hippocampal interstitial fluid (ISF) were run according to the provided manufacturer protocols (mouse HMGB1; (Novus Biologicals).
Liu H, Ghosh S, Vaidya T et al. Activated cGAS/STING signaling elicits endothelial cell senescence in early diabetic retinopathy JCI insight 2023-06-22 [PMID: 37345657] (ELISA)	ELISA
Ghosh P, Sasaki K, Pulido Ruiz IA et al. Inflammatory macrophage to hepatocyte signals can be prevented by extracellular vesicle reprogramming Journal of cell science 2023-04-13 [PMID: 37051862] (ELISA, Mouse)	ELISA	Mouse
Chang L, Chin Y, Wu P et al. Polymeric nano-formulation of spectrum selective RTK inhibitor strengthens anti-cancer effects via immune remodeling by endoplasmic reticulum stress-modulating mitochondrial metabolism Nano Today 2024-02-01 (ELISA, Mouse)	ELISA	Mouse
Zhang J, Brown R, Hogan M, Wang J Mitigating Scar Tissue Formation in Tendon Injuries: Targeting HMGB1, AMPK Activation, and Myofibroblast Migration All at Once preprints.org 2023-11-13 [PMID: 38139865] (ELISA)	ELISA
Yiwei Zhu, Lin Lei, Xinghui Wang, Linfang Chen, Wei Li, Jinxia Li, Chenchen Zhao, Xiliang Du, Yuxiang Song, Wenwen Gao, Guowen Liu, Xinwei Li The E3 ubiquitin ligase NEDD4-1 protects against acetaminophen-induced liver injury by targeting VDAC1 for degradation Acta Pharmaceutica Sinica. B 2023-01-29 [PMID: 37139424]
Deng B, yang D, Wu H et al. Ketamine inhibits TNF-alpha-induced cecal damage by enhancing RIP1 ubiquitination to attenuate lethal SIRS Cell death discovery 2022-02-19 [PMID: 35184141]
Israr Ahmad, Adam Molyvdas, Ming-Yuan Jian, Ting Zhou, Amie M. Traylor, Huachun Cui, Gang Liu, Weifeng Song, Anupam Agarwal, Tamas Jilling, Saurabh Aggarwal, Sadis Matalon AICAR decreases acute lung injury by phosphorylating AMPK and upregulating heme oxygenase-1 The European respiratory journal 2022-05-28 [PMID: 34049949]
Go EJ, Yang H, Chon HJ et al. Combination of Irreversible Electroporation and STING Agonist for Effective Cancer Immunotherapy Cancers 2020-10-26 [PMID: 33114476] (ELISA)	ELISA
Shi C, Wang Z, Wang L et al. A nanotrap improves survival in severe sepsis by attenuating hyperinflammation Nat Commun 2020-07-07 [PMID: 32636379] (ELISA, Mouse)	ELISA	Mouse

Array NBP2-62767

• HMGB1/HMG-1 Antibodies
• HMGB1/HMG-1 Antibody Pair
• HMGB1/HMG-1 ELISA Kits
• HMGB1/HMG-1 Lysate
• HMGB1/HMG-1 Proteins
• HMGB1/HMG-1 Proteins and Enzyme