Species: Hu, Mu, Rt, Bv, Ca, Rb, Sh, Po, Eq
Applications: WB, Simple Western, ELISA, Flow, ICC/IF, IHC, KD
Host: Rabbit Polyclonal
Species: Hu
Applications: WB, IHC, ChIP, CyTOF-ready, Flow, ICC/IF
Host: Mouse Monoclonal
Species: Hu, Ec
Applications: WB, ELISA, ICC/IF, IHC, B/N, KD
Host: Mouse Monoclonal
Species: Hu
Applications: ELISA
Host: Monoclonal
Species: Hu
Applications: ELISA
Species: Mu
Applications: ELISA
Species: Mu
Applications: ELISA
Species: Hu
Applications: WB
Species: Hu
Applications: PAGE
Species: Mu
Applications: AC
Species: Mu
Applications: ELISA, Bioactivity
Description
HMGB1 and HMGB2 are part of the chromatin non-histone high mobility group proteins 1 and 2. HMGB1 and HMGB2 (containing multiple HMG-boxes) are conserved domains of 80 amino acids which mediate the DNA binding of many proteins. HMG box domains recognize DNA structure. Both HMGB1 and HMGB2 contain a N-terminal HMG box, a central HMG box, and an acidic carboxy terminus. The acidic tails of HMGB1 and HMGB2 contain multiple serine residues which match the phosphorylation consensus sites of casein kinase II, and phosphorylation of this domain appears to be important for proper functioning of these proteins. HMGB1 and HMGB2 have been shown to facilitate the binding of various sequence-specific transcription factors to their respective DNA binding sites. HMGB1 and HMGB2 may also serve as architectural factors that recognize and mediate DNA structural changes that accompany various events such as DNA repair, transcription, and replication.
Bioinformatics
| Entrez |
Mouse
Rat
Human
|
| Uniprot |
Human
Human
Human
Human
Human
Human
Mouse
Rat
|
| Product By Gene ID |
3146 |
| Alternate Names |
- Amphoterin
- high mobility group box 1
- High mobility group protein 1
- high mobility group protein B1
- high-mobility group (nonhistone chromosomal) protein 1
- high-mobility group box 1
- HMG-1
- HMG1DKFZp686A04236
- HMG3
- SBP-1
- Sulfoglucuronyl carbohydrate binding protein
|
![Western Blot HMGB1/HMG-1 Antibody (115603) [Unconjugated]](http://images.novusbio.com/fullsize2/HMGB1_MAB1690_Western_Blot_16821.jpg)
![Chromatin Immunoprecipitation (ChIP) HMGB1/HMG-1 Antibody (115603) [Unconjugated]](http://images.novusbio.com/fullsize2/HMGB1_MAB1690_Chromatin_Immunoprecipitation_11247.jpg)
![Intracellular Staining by Flow Cytometry HMGB1/HMG-1 Antibody (115603) [Unconjugated]](http://images.novusbio.com/fullsize2/HMGB1_MAB1690_Flow_Cytometry_8344.jpg)
![Immunocytochemistry HMGB1/HMG-1 Antibody (115603) [Unconjugated]](http://images.novusbio.com/fullsize2/HMGB1_MAB1690_Immunocytochemistry_10338.jpg)
![Immunohistochemistry HMGB1/HMG-1 Antibody (115603) [Unconjugated]](http://images.novusbio.com/fullsize2/HMGB1_MAB1690_Immunohistochemistry_24145.jpg)
![Western Blot HMGB1/HMG-1 Antibody (115603) [Unconjugated]](http://images.novusbio.com/fullsize/mab1690_human-hmgb1-mab-clone-115603-41202412505382.jpg)
![Western Blot HMGB1/HMG-1 Antibody (115603) [Unconjugated]](http://images.novusbio.com/fullsize/mab1690_human-hmgb1-mab-clone-115603-41202412512686.jpg)
![Immunohistochemistry HMGB1/HMG-1 Antibody (115603) [Unconjugated]](http://images.novusbio.com/fullsize/mab1690_human-hmgb1-mab-clone-115603-4120241250537.jpg)
