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Hepcidin Antimicrobial Peptide Antibody (1F9)

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Immunohistochemistry-Paraffin: Hepcidin Antimicrobial Peptide Antibody (1F9) [H00057817-M02] - Immunoperoxidase of monoclonal antibody to HAMP ( Cat # H00057817-M02 ) on formalin-fixed paraffin-embedded human liver. ...read more
ELISA: Hepcidin Antimicrobial Peptide Antibody (1F9) [H00057817-M02] - Detection limit for recombinant GST tagged HAMP is approximately 0.03ng/ml as a capture antibody.

Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, ELISA, IHC
Clone
1F9
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated

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Hepcidin Antimicrobial Peptide Antibody (1F9) Summary

Immunogen
HAMP (AAH20612, 25 a.a. ~ 84 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. SVFPQQTGQLAELQPQDRAGARASWMPMFQRRRRRDTHFPICIFCCGCCHRSKCGMCCKT
Specificity
HAMP - hepcidin antimicrobial peptide
Isotype
IgG1 Kappa
Clonality
Monoclonal
Host
Mouse
Gene
HAMP
Purity
IgG purified
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Applications/Dilutions

Dilutions
  • ELISA 1:100-1:2000
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 1:10-1:500
  • Western Blot 1:500
Application Notes
Antibody reactive against recombinant protein for Western Blot. Has also been used for immunohistochemistry (paraffin) and ELISA.

Packaging, Storage & Formulations

Storage
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Buffer
In 1x PBS, pH 7.4
Preservative
No Preservative
Purity
IgG purified

Notes

This product is produced by and distributed for Abnova, a company based in Taiwan.

Alternate Names for Hepcidin Antimicrobial Peptide Antibody (1F9)

  • HAMP
  • HEPC
  • hepcidin antimicrobial peptide
  • Hepcidin
  • HEPCPutative liver tumor regressor
  • HFE2B
  • HFE2Bhepcidin
  • LEAP1
  • LEAP-1
  • LEAP1PLTR
  • Liver-expressed antimicrobial peptide 1
  • PLTR

Background

The product encoded by this gene is involved in the maintenance of iron homeostasis, and it is necessary for the regulation of iron storage in macrophages, and for intestinal iron absorption. The preproprotein is post-translationally cleaved into mature peptides of 20, 22 and 25 amino acids, and these active peptides are rich in cysteines, which form intramolecular bonds that stabilize their beta-sheet structures. These peptides exhibit antimicrobial activity. Mutations in this gene cause hemochromatosis type 2B, also known as juvenile hemochromatosis, a disease caused by severe iron overload that results in cardiomyopathy, cirrhosis, and endocrine failure.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol HAMP
Entrez
OMIM
Uniprot