HDAC6 Antibody [DyLight 650] Summary
Immunogen |
A synthetic peptide made to a C-terminal portion of the human HDAC6 protein (between residues 1175-1215). [UniProt Q9UBN7] |
Localization |
Nucleus. Cytoplasm. Note: It is cytoplasmic when associated with microtubules. |
Isotype |
IgG |
Clonality |
Polyclonal |
Host |
Rabbit |
Gene |
HDAC6 |
Purity |
Immunogen affinity purified |
Innovator's Reward |
Test in a species/application not listed above to receive a full credit towards a future purchase. |
Applications/Dilutions
Dilutions |
- Flow Cytometry
- Immunocytochemistry/ Immunofluorescence 1:100
|
Application Notes |
Optimal dilution of this antibody should be experimentally determined. |
Packaging, Storage & Formulations
Storage |
Store at 4C in the dark. |
Buffer |
50mM Sodium Borate |
Preservative |
0.05% Sodium Azide |
Purity |
Immunogen affinity purified |
Notes
DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.
Alternate Names for HDAC6 Antibody [DyLight 650]
Background
Histone deacetylase 6 (HDAC-6, HD6, and JM21) is a class II histone deacetylase/AcuC/AphA family member. HDAC-6 primarily functions to alter chromosome structure, regulate transcription factor access to DNA, and deacetylate the lysine residues on the N-terminal region of histones. The deacetylase activity, in turn, has a role in the degradation of misfolded proteins by autophagy (PMID: 21235576). The HDAC-6 protein contains two catalytic domains that function independently of each other and plays an important role in cell motility (microtubule dependent) by the deacetylation of tubulin. Research involving HDAC-6 includes cancer development and progression, Parkinson's disease, and epigenetics (PMID: 21455583, 21235576).
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are
guaranteed for 1 year from date of receipt.
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