GSK-3 beta [p Tyr279, p Tyr216] Antibody

Glycogen synthase kinase 3 (GSK3) is a proline directed serine threonine kinase that was initially identified as a phosphorylating and inactivating glycogen synthase, a key enzyme in glycogen metabolism. Since then, it has been shown to be involved in the regulation of a diverse array of cellular functions, including protein synthesis, cell proliferation, cell differentiation, microtubule assembly/disassembly, and apoptosis. GSK3s substrate specificity is unique in that phosphorylation of substrate only occurs if a phosphoserine or phosphotyrosine is present four residues C terminal to the site of GSK phosphorylation.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 3 confirmed species: Human, Mouse, Mammal.

We have publications tested in 3 applications: IF/IHC, IHC-P, WB.

Showing Publications 1 - 10 of 10.

Publications using NB100-81946	Applications	Species
Xu M, Lantz MJ, Nichols RA, Li QX Anti-Neuroinflammatory Effects of a Semi-Synthetic Isoorientin-Based Glycogen Synthase Kinase-3beta Inhibitor in Lipopolysaccharide-Activated Microglial Cells ACS chemical neuroscience 2022-01-05 [PMID: 34913695]
Hsing C, Tsai C, Chen C Et Al. Pharmacologically Inhibiting Glycogen Synthase Kinase-3beta Ameliorates Renal Inflammation and Nephrotoxicity in an Animal Model of Cisplatin-Induced Acute Kidney Injury Biomedicines 2021-07-25 [PMID: 34440091] (IHC-P)	IHC-P
Takaichi Y, Chambers JK, Ano Y et al. Deposition of Phosphorylated alpha -Synuclein and Activation of GSK-3 beta and PP2A in the PS19 Mouse Model of Tauopathy Journal of neuropathology and experimental neurology 2021-06-21 [PMID: 34151989]
Takaichi Y, Chambers JK, Takahashi K, et al. Amyloid beta and tau pathology in brains of aged pinniped species (sea lion, seal, and walrus) Acta neuropathologica communications 2021-01-07 [PMID: 33413691] (IHC-P, Mammal)	IHC-P	Mammal
Wu L, Lin W, Liao Q et al. Calcium Channel Blocker Nifedipine Suppresses Colorectal Cancer Progression and Immune Escape by Preventing NFAT2 Nuclear Translocation Cell Rep 2020-10-27 [PMID: 33113363] (WB, Human)	WB	Human
Liu Z, Selby CP, Yang Y et al. Circadian regulation of c-MYC in mice Proc. Natl. Acad. Sci. U.S.A. 2020-08-19 [PMID: 32817420] (WB, Mouse)	WB	Mouse
Takaichi Y, Chambers JK, Inoue H et al. Phosphorylation and oligomerization of alpha-synuclein associated with GSK-3 beta activation in the rTg4510 mouse model of tauopathy Acta Neuropathol Commun 2020-06-19 [PMID: 32560668] (IF/IHC, Mouse)	IF/IHC	Mouse
Wu X, Kosaraju J, Tam kY. Anti-neuroinflammatory effects of SLOH in AB-induced BV-2 microglial cells and 3xTg-AD mice involve the inhibition of GSk-3B. Neurosci. Lett. 2018-09-29 [PMID: 30278248] (WB, Mouse)	WB	Mouse
Wu X, Kosaraju J, Zhou W, Tam KY. SLOH, a carbazole-based fluorophore, mitigates neuropathology and behavioral impairment in the triple-transgenic mouse model of Alzheimer's disease Neuropharmacology 2018-01-05 [PMID: 29309769] (Mouse)		Mouse
Denysenko T, Annovazzi L, Cassoni P et al. WNT/b-catenin Signaling Pathway and Downstream Modulators in Low- and High-grade Glioma. Cancer Genomics Proteomics. 2015-12-28 [PMID: 26708597] (IHC-P, Human)	IHC-P	Human

Array NB100-81946

• GSK-3 beta Antibodies
• GSK-3 beta ELISA Kits
• GSK-3 beta Lysate
• GSK-3 beta Protein
• GSK-3 beta Proteins and Enzyme