GRP75/HSPA9B/Mortalin Antibody

The HSP 70 family comprises four highly conserved proteins, HSP 70, HSC 70, GRP 75 and GRP 78, which serve a variety of roles. They act as molecular chaperones facilitating the assembly of multi-protein complexes, participate in the translocation of polypeptides across cell membranes and to the nucleus, and aid in the proper folding of nascent polypeptide chains. HSC 70, GRP 75 and GRP 78 are constitutively expressed in primate cells. HSP 70 expression is strongly induced in response to heat stress. HSP 70 and HSC 70, which are found in both the cytosol and nucleus of mammalian cells, play key roles in the cytosolic endoplasmic reticulum and mitochondrial import machinery. They are involved in chaperoning nascent polypeptide chains and in protecting cells against the accumulation of improperly folded proteins. GRP 75 and GRP 78 are unresponsive to heat stress and are induced by glucose deprivation. GRP 75 expression is restricted to the mitochondrial matrix and aids in the translocation and folding of nascent polypeptide chains of both nuclear and mitochondrial origin. GRP 78 is localized in the endoplasmic reticulum, where it receives imported secretory proteins and is involved in the folding and translocation of nascent peptide chains. Research indicates that members of the HSP 70 family may act as force-generating motors, relying on the hydrolysis of ATP for their activity.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: IF/IHC.

Showing Publication 1 - 1 of 1.

Publication using NBP1-89729	Applications	Species
Morisaki T, Yashiro M, Kakehashi A, et al. Comparative Proteomics Analysis of Gastric Cancer Stem Cells PLos One. 2014-11-07 [PMID: 25379943] (IF/IHC, Human) Details: Chorein/VPS13A antibody used for IHC- P at 1:500 dilution on gastric cancer tissue specimens - antigen retrieval for 10 minutes at 105C by autoclave in Target Retrieval Solution, endogenous peroxidase blocked with 3%H2O2, On/4C incubation for primary, streptavidin-peroxidase-DAB detection (Figure 3).	IF/IHC	Human

Array NBP1-89729

• GRP75/HSPA9B/Mortalin Antibodies
• GRP75/HSPA9B/Mortalin ELISA Kits
• GRP75/HSPA9B/Mortalin Lysate
• GRP75/HSPA9B/Mortalin Proteins