GRP75/HSPA9B/Mortalin Products

Description

The HSP 70 family comprises four highly conserved proteins, HSP 70, HSC 70, GRP 75 and GRP 78, which serve a variety of roles. They act as molecular chaperones facilitating the assembly of multi-protein complexes, participate in the translocation of polypeptides across cell membranes and to the nucleus, and aid in the proper folding of nascent polypeptide chains. HSC 70, GRP 75 and GRP 78 are constitutively expressed in primate cells. HSP 70 expression is strongly induced in response to heat stress. HSP 70 and HSC 70, which are found in both the cytosol and nucleus of mammalian cells, play key roles in the cytosolic endoplasmic reticulum and mitochondrial import machinery. They are involved in chaperoning nascent polypeptide chains and in protecting cells against the accumulation of improperly folded proteins. GRP 75 and GRP 78 are unresponsive to heat stress and are induced by glucose deprivation. GRP 75 expression is restricted to the mitochondrial matrix and aids in the translocation and folding of nascent polypeptide chains of both nuclear and mitochondrial origin. GRP 78 is localized in the endoplasmic reticulum, where it receives imported secretory proteins and is involved in the folding and translocation of nascent peptide chains. Research indicates that members of the HSP 70 family may act as force-generating motors, relying on the hydrolysis of ATP for their activity.

Bioinformatics

Entrez	15526 Mouse 291671 Rat 3313 Human
Uniprot	AAH00478 Human AAH00478.1 Human NM_004134 Human P38646 Human
Product By Gene ID	3313
Alternate Names	75 kDa glucose-regulated protein GRP-75 GRP75mthsp75 Heat shock 70 kDa protein 9 heat shock 70kD protein 9B heat shock 70kDa protein 9 (mortalin) heat shock 70kDa protein 9B (mortalin-2) HSPA9BMGC4500 Mortalin mortalin, perinuclear mortalin-2 MOT MOT2 mot-2 MTHSP75 p66-mortalin PBP74CSA Peptide-binding protein 74 stress-70 protein, mitochondrial

Research Areas for GRP75/HSPA9B/Mortalin

Find related products by research area and learn more about each of the different research areas below.

Core ESC-Like Genes
Stem Cell Markers