GPR39 Antibody - BSA Free

GPR39 (G-protein coupled receptor 39) is an orphan GPCR receptor from ghrelin/motilin receptor subfamily of G-protein coupled receptor 1 family, and it is constitutively active with Zn2+ as its physiological agonist. GPR39 is a multipass transmembrane protein found in cell membranes and is expressed in several tissues such as stomach, intestine and hypothalamus. Obestatin, a 23 amino acid peptide originating from ghrelin precursor, was originally shown to be the endogenous ligand of GPR39, a study that happened to be non-reproducible, and later on it was shown that obestatin does not bind, nor activate GPR39 but that Zn2+ could stimulate GPR39 signalling in vitro, thereby inferring that obestatin is not the natural ligand of GPR39. GPR39 receptor also displays a strong ligand-independent signaling activity through G-alpha12/13 as well as G-alphaq. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. GPR39 has been shown to implicate in the regulation of insulin release/pancreatic function, body weight, gastrointestinal mobility, hormone secretion and cell death.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 3 applications: IF/IHC, IHC-P, WB.

Showing Publications 1 - 4 of 4.

Publications using NLS139	Applications	Species
Tang Y, Yang J, Ye C Et al. miR-182 mediated the inhibitory effects of NF- kappa B on the GPR39/CREB/BDNF pathway in the hippocampus of mice with depressive-like behaviors Behavioural Brain Research 2022-02-01 [PMID: 34743948] (WB, Mouse)	WB	Mouse
Wu X, Dou Y, Xu H, Jiang Z The expression and clinical significance of GPR39 in colon cancer Irish journal of medical science 2021-09-29 [PMID: 34586565] (IHC-P, Human)	IHC-P	Human
Yang Q, Li Y, Zhang X, Chen D. Zac1/GPR39 phosphorylating CaMK-II contributes to the distinct roles of Pax3 and Pax7 in myogenic progression. Biochim Biophys Acta Mol Basis Dis 2018-02-01 [PMID: 29079520]
Zhao H, Qiao J, Zhang S et al. GPR39 marks specific cells within the sebaceous gland and contributes to skin wound healing Sci Rep. 2015-01-21 [PMID: 25604641] (IF/IHC, Mouse)	IF/IHC	Mouse

Array NLS139

• GPR39 Antibodies
• GPR39 Proteins