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Glucosamine (N-acetyl)-6-Sulfatase/GNS Antibody - BSA Free

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Western Blot: Glucosamine (N-acetyl)-6-Sulfatase/GNS Antibody [NBP1-69352] - Human liver.
Immunohistochemistry: Glucosamine (N-acetyl)-6-Sulfatase/GNS Antibody [NBP1-69352] - Formalin fixed paraffin embedded human heart tissue, cytoplasmic staining.
Immunohistochemistry: Glucosamine (N-acetyl)-6-Sulfatase/GNS Antibody [NBP1-69352] - Formalin Fixed paraffin embedded human liver tissue, cytoplasmic staining of Kupffer cells in sinusoids

Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, IHC
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Format
BSA Free
Concentration
0.5 mg/ml

Order Details

Glucosamine (N-acetyl)-6-Sulfatase/GNS Antibody - BSA Free Summary

Description
The addition of 50% glycerol is optional for those storing this antibody at -20C and not aliquoting smaller units. However, please note that glycerol may interrupt some downstream antibody applications and should be added with caution.
Immunogen
Synthetic peptides corresponding to GNS(glucosamine (N-acetyl)-6-sulfatase (Sanfilippo disease IIID)) The peptide sequence was selected from the C terminal of GNS. Peptide sequence PILRGASNLTWRSDVLVEYQGEGRNVTDPTCPSLSPGVSQCFPDCVCEDA. The peptide sequence for this immunogen was taken from within the described region.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
GNS
Purity
Affinity purified
Innovator's Reward
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Applications/Dilutions

Dilutions
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin
  • Western Blot 1.0 ug/ml
Theoretical MW
58 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS, 2% Sucrose
Preservative
0.09% Sodium Azide
Concentration
0.5 mg/ml
Purity
Affinity purified

Alternate Names for Glucosamine (N-acetyl)-6-Sulfatase/GNS Antibody - BSA Free

  • EC 3.1.6
  • EC 3.1.6.14
  • G6Sglucosamine-6-sulfatase
  • glucosamine (N-acetyl)-6-sulfatase
  • Glucosamine6Sulfatase
  • Glucosamine-6-Sulfatase
  • GNS
  • MGC21274
  • N-acetylglucosamine-6-sulfatase

Background

GNS is a lysosomal enzyme found in all cells. It is involved in the catabolism of heparin, heparin sulphate, and keratan sulphate. Deficiency of this enzyme results in the accumulation of undegraded substrate and the lysosomal storage disorder ucopolysaccharidosis type IIID (Sanfilippo D syndrome). Mucopolysaccharidosis type IIID is the least common of the four subtypes of Sanfilippo syndrome.The product of this gene is a lysosomal enzyme found in all cells. It is involved in the catabolism of heparin, heparan sulphate, and keratan sulphate. Deficiency of this enzyme results in the accumulation of undegraded substrate and the lysosomal storage disorder mucopolysaccharidosis type IIID (Sanfilippo D syndrome). Mucopolysaccharidosis type IIID is the least common of the four subtypes of Sanfilippo syndrome.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol GNS
Uniprot