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GITR/TNFRSF18 Antibody (110416) [DyLight 755]

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, Flow, B/N, CyTOF-ready, ELISA, ELISA(Cap), ELISA(Det)
Clone
110416
Clonality
Monoclonal
Host
Mouse
Conjugate
DyLight 755

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 350
FAB689U-100UG
Alexa Fluor 405
FAB689V-100UG
Alexa Fluor 532
FAB689X
Alexa Fluor 594
FAB689T-100UG
Alexa Fluor 647
FAB689R-100UG
Alexa Fluor 700
FAB689N-025
Alexa Fluor 700
FAB689N-100
Alexa Fluor 750
FAB689S-100UG
Allophycocyanin
FAB689A-025
Allophycocyanin
FAB689A-100
Allophycocyanin/Cy7
FAB689APCCY7
Biotin
FAB689B
CoraFluor 1
FAB689CL1
DyLight 350
FAB689D
DyLight 405
FAB689E
DyLight 488
FAB689K
DyLight 550
FAB689L
DyLight 594
FAB689M
DyLight 650
FAB689W
DyLight 680
FAB689Y
Fluorescein
FAB689F-025
Fluorescein
FAB689F-100
HRP
FAB689H
Janelia Fluor 525
FAB689JF525
Janelia Fluor 549
FAB689I
Janelia Fluor 585
FAB689JF585
Janelia Fluor 635
FAB689JF635
Janelia Fluor 646
FAB689J
Janelia Fluor 669
FAB689JF669
PE/Atto594
FAB689PEATT594
PE/Cy5.5
FAB689PECY55
PE/Cy7
FAB689PECY7
PerCP
FAB689C
Phycoerythrin
FAB689P-025
Phycoerythrin
FAB689P-100
Unconjugated
MAB689-100
mFluor Violet 450 SE
FAB689MFV450
mFluor Violet 500 SE
FAB689MFV500
mFluor Violet 610 SE
FAB689MFV610
View Available Formulations
Catalog# & Formulation Size Price
Standard Formulation
MAB689-100
Carrier Free
FAB689F-025
Carrier Free
FAB689S-100UG
Carrier Free
FAB689T-100UG
Carrier Free
FAB689U-100UG
Carrier Free
FAB689V-100UG
Carrier Free
MAB689-500
Carrier Free
MAB689-100
Carrier Free
FAB689F-100
Carrier Free
MAB689-SP
Carrier Free
FAB689P-025
Carrier Free
FAB689P-100
Carrier Free
FAB689A-025
Carrier Free
FAB689A-100
Carrier Free
FAB689N-025
Carrier Free
FAB689N-100
Carrier Free
FAB689R-100UG
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GITR/TNFRSF18 Antibody (110416) [DyLight 755] Summary

Immunogen
Mouse myeloma cell line NS0-derived recombinant human GITR/TNFRSF18
Gln26-Glu161 (Thr43Ala)
Accession # Q9Y5U5
Specificity
Detects human GITR in direct ELISAs and Western blots. Does not cross-react with recombinant human (rh) 4‑1BB, recombinant mouse
(rm) 4‑1BB, rhCD27, rmCD27, rhCD30, rmCD30, rhCD40, rmCD40, rhDR3, rhDR6, rhEDAR, rmEDAR, rhFas, rmFAS, rmGITR, rhHVEM, rhLymphotoxin R beta , rmLymphotoxin R beta , rhNGF R, rhOPG, rmOPG, rhRANK, rmRANK, rhTAJ, rhTNF RI, rmTNF RI, rhTNF RII, or rmTNF RII.
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
TNFRSF18
Purity
Protein A or G purified from hybridoma culture supernatant
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.
Learn about the Innovator's Reward

Applications/Dilutions

Dilutions
  • Blockade of Receptor-ligand Interaction
  • CyTOF-ready
  • ELISA Capture (Matched Antibody Pair)
  • ELISA Detection (Matched Antibody Pair)
  • ELISA Standard (Matched Pair)
  • Flow Cytometry
  • Western Blot
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Protein A or G purified from hybridoma culture supernatant

Notes

DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

Alternate Names for GITR/TNFRSF18 Antibody (110416) [DyLight 755]

  • Activation-inducible TNFR family receptor
  • AITR
  • AITRTNF receptor superfamily activation-inducible protein
  • CD357 antigen
  • CD357
  • GITR
  • GITR-D
  • GITRtumor necrosis factor receptor superfamily member 18
  • Glucocorticoid-induced TNFR-related protein
  • TNFRSF18
  • tumor necrosis factor receptor superfamily, member 18

Background

GITR is encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been shown to have increased expression upon T-cell activation, and it is thought to play a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells. Knockout studies in mice also suggest the role of this receptor is in the regulation of CD3-driven T-cell activation and programmed cell death. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol TNFRSF18