FXR/NR1H4 Products

Description

FXR and LXR fall into a category of proteins termed orphan receptors; because of their lack of a defined function, and in the case of LXR, the lack of a defined ligand. FXR has been shown to bind a class of lipid molecules called farnesoids. LXR/RXR heterodimers have highest affinity for DR-4 DNA elements while FXR/RXR heterodimers bind IR-1 elements. Both LXR/RXR and FXR/RXR heterodimers retain their responsiveness to 9-cis retinoic acid. The steroid receptor superfamily acts through direct association with DNA sequences known as hormone response elements (HREs) and bind DNA as either homo- or heterodimers. The promiscuous mediator of heterodimerization, RXR, is the receptor for 9-cis retinoic acid, and dimerizes with VDR, TR, PPAR, as well as several novel receptors including LXR (also referred to as RLD-1) and FXR.

Bioinformatics

Entrez	20186 Mouse 9971 Human
Uniprot	B6ZGS9 Human NM_005123 Human NP_005114 Human NP_005114.1 Human Q60641 Mouse Q96RI1 Human
Product By Gene ID	9971
Alternate Names	bile acid receptor farnesoid X receptor Farnesoid X-activated receptor Farnesol receptor HRR-1 FXRBAR HRR-1 HRR1MGC163445 Nuclear receptor subfamily 1 group H member 4 nuclear receptor subfamily 1, group H, member 4 Retinoid X receptor-interacting protein 14 RIP14RXR-interacting protein 14

Research Areas for FXR/NR1H4

Find related products by research area and learn more about each of the different research areas below.

Cancer
Chromatin Research
Lipid and Metabolism
Signal Transduction