Human FGF-19 Quantikine ELISA Kit

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

The Fibroblast Growth Factor (FGF) family consists of at least 22 highly conserved proteins and are found in many species ranging from C. elegans and Drosophila to humans (1). FGFs are heparin-binding growth factors with a core 120 amino acid (aa) FGF domain that allows for a common tertiary structure. In general, FGFs are expressed during embryonic development and in restricted adult tissues. They act on cells of mesodermal and neuroectodermal origin to regulate diverse physiologic functions including angiogenesis, cell growth, pattern formation, metabolic regulation, cell migration, neurotrophic effects, and tissue repair (2). The activities of the FGF family are mediated by four receptors, FGF R1 through FGF R4 (2). The receptors are transmembrane proteins with a tyrosine kinase domain and are thought to act as classical receptor tyrosine kinases. FGF R5/FGF RL1 has also been described, but lacks the kinase domain and signaling capability (3). 

We have publications tested in 1 confirmed species: Human.

Showing Publications 1 - 10 of 37. Show All 37 Publications. Collapse Publications.

Publications using DF1900	Applications	Species
Oostveen, RF;Kaiser, Y;Hartgers, ML;Meessen, ECE;Grefhorst, A;Hovingh, GK;Kuipers, F;Stroes, ESG;Groen, AK;Reeskamp, LF; Ursodeoxycholic Acid for Trans Intestinal Cholesterol Excretion Stimulation: A Randomized Placebo Controlled Crossover Study Journal of the American Heart Association 2024-10-15 [PMID: 39377212] (Human)		Human
Wahlström, A;Aydin, Ö;Olsson, LM;Sjöland, W;Henricsson, M;Lundqvist, A;Marschall, HU;Franken, R;van de Laar, A;Gerdes, V;Meijnikman, AS;Hofsø, D;Groen, AK;Hjelmesæth, J;Nieuwdorp, M;Bäckhed, F; Alterations in bile acid kinetics after bariatric surgery in patients with obesity with or without type 2 diabetes EBioMedicine 2024-08-02 [PMID: 39096744] (Human)		Human
Xue, T;Wang, X;Pan, X;Liu, M;Xu, F; PTX promotes breast cancer migration and invasion by recruiting ATF4 to upregulate FGF19 Cellular signalling 2024-07-23 [PMID: 39053672] (Human)		Human
Christidis, G;Küppers, F;Karatayli, SC;Karatayli, E;Weber, SN;Lammert, F;Krawczyk, M; Skin advanced glycation end-products as indicators of the metabolic profile in diabetes mellitus: correlations with glycemic control, liver phenotypes and metabolic biomarkers BMC endocrine disorders 2024-03-05 [PMID: 38443880] (Human)		Human
Goralska, J;Razny, U;Gruca, A;Zdzienicka, A;Micek, A;Dembinska-Kiec, A;Solnica, B;Malczewska-Malec, M; Plasma Cytokeratin-18 Fragment Level Reflects the Metabolic Phenotype in Obesity Biomolecules 2023-04-14 [PMID: 37189422] (Human)		Human
RO Ali, GM Quinn, R Umarova, JA Haddad, GY Zhang, EC Townsend, L Scheuing, KL Hill, M Gewirtz, S Rampertaap, SD Rosenzweig, AT Remaley, JM Han, V Periwal, H Cai, PJ Walter, C Koh, EB Levy, DE Kleiner, O Etzion, T Heller Longitudinal multi-omics analyses of the gut-liver axis reveals metabolic dysregulation in hepatitis C infection and cirrhosis Nature Microbiology, 2022-12-15;0(0):. 2022-12-15 [PMID: 36522461] (Human)		Human
X Yuan, R Wang, B Han, C Sun, R Chen, H Wei, L Chen, H Du, G Li, Y Yang, X Chen, L Cui, Z Xu, J Fu, J Wu, W Gu, Z Chen, X Fang, H Yang, Z Su, J Wu, Q Li, M Zhang, Y Zhou, L Zhang, G Ji, F Luo Functional and metabolic alterations of gut microbiota in children with new-onset type 1 diabetes Nature Communications, 2022-10-26;13(1):6356. 2022-10-26 [PMID: 36289225] (Human)		Human
S Sydor, C Dandyk, J Schwerdt, P Manka, D Benndorf, T Lehmann, K Schallert, M Wolf, U Reichl, A Canbay, LP Bechmann, R Heyer Discovering Biomarkers for Non-Alcoholic Steatohepatitis Patients with and without Hepatocellular Carcinoma Using Fecal Metaproteomics International Journal of Molecular Sciences, 2022-08-09;23(16):. 2022-08-09 [PMID: 36012106] (Human)		Human
JY Guo, HH Chen, WJ Lee, SC Chen, SD Lee, CY Chen Fibroblast Growth Factor 19 and Fibroblast Growth Factor 21 Regulation in Obese Diabetics, and Non-Alcoholic Fatty Liver Disease after Gastric Bypass Nutrients, 2022-02-02;14(3):. 2022-02-02 [PMID: 35277004] (Human)		Human
N Memon, CW Lee, A Herdt, BI Weinberger, T Hegyi, MO Carayannop, LM Aleksunes, GL Guo, IJ Griffin Suppression of Bile Acid Synthesis in a Preterm Infant Receiving Prolonged Parenteral Nutrition Journal of clinical and experimental hepatology, 2021-04-13;12(1):200-203. 2021-04-13 [PMID: 35068799] (Human)		Human
J Wang, H Zhao, L Zheng, Y Zhou, L Wu, Y Xu, X Zhang, G Yan, H Sheng, R Xin, L Jiang, J Lei, J Zhang, Y Chen, J Peng, Q Chen, S Yang, K Yu, D Li, Q Xie, Y Li FGF19/SOCE/NFATc2 signaling circuit facilitates the self-renewal of liver cancer stem cells Theranostics, 2021-03-05;11(10):5045-5060. 2021-03-05 [PMID: 33754043] (Human)		Human
F Mao, MX Wang, X Hou, Z Zhou, YY Yan, LJ Fang, Z Tan, WY Fang, T Liu, W He, C Li, XB Xie, SQ Lu, J Sui, F Wang, L Han, JS Wang, W Li NTCP Deficiency Causes Gallbladder Abnormalities in Mouse and Human Beings Cell Mol Gastroenterol Hepatol, 2020-09-09;0(0):. 2020-09-09 [PMID: 32919083] (Human)		Human
A Wilson, Q Wang, AA Almousa, LE Jansen, YH Choi, UI Schwarz, RB Kim Genetic variation in the farnesoid X-receptor predicts Crohn's disease severity in female patients Sci Rep, 2020-07-16;10(1):11725. 2020-07-16 [PMID: 32678214] (Human)		Human
WS Liu, MJ Tang, TL Xu, JB Su, XQ Wang, F Xu, DM Zhang, Q Zhu, J Cao, H Wang Association of serum fibroblast growth factor 19 levels with arteriosclerosis parameters assessed by arterial stiffness and atherogenic index of plasma in patients with type 2 diabetes Diabetol Metab Syndr, 2020-05-20;12(0):44. 2020-05-20 [PMID: 32477430] (Human)		Human
G Calderon, A McRae, J Rievaj, J Davis, I Zandvakili, S Linker-Nor, D Burton, G Roberts, F Reimann, B Gedulin, A Vella, NF LaRusso, M Camilleri, FM Gribble, A Acosta Ileo-colonic delivery of conjugated bile acids improves glucose homeostasis via colonic GLP-1-producing enteroendocrine cells in human obesity and diabetes EBioMedicine, 2020-04-25;55(0):102759. 2020-04-25 [PMID: 32344198] (Human)		Human
J Góralska, U Ra?ny, A Polus, A Dziewo?ska, A Gruca, A Zdzienicka, A Dembi?ska-, B Solnica, A Micek, M Kapusta, K S?owi?ska-, M Malczewska Enhanced GIP Secretion in Obesity Is Associated with Biochemical Alteration and miRNA Contribution to the Development of Liver Steatosis Nutrients, 2020-02-13;12(2):. 2020-02-13 [PMID: 32069846] (Human)		Human
A Wilson, A Almousa, WA Teft, RB Kim Attenuation of bile acid-mediated FXR and PXR activation in patients with Crohn's disease Sci Rep, 2020-02-05;10(1):1866. 2020-02-05 [PMID: 32024859] (Human)		Human
AE O'Mara, JW Johnson, JD Linderman, RJ Brychta, S McGehee, LA Fletcher, YA Fink, D Kapuria, TM Cassimatis, N Kelsey, C Cero, Z Abdul-Sate, F Piccinini, AS Baskin, BP Leitner, H Cai, CM Millo, W Dieckmann, M Walter, NB Javitt, Y Rotman, PJ Walter, M Ader, RN Bergman, P Herscovitc, KY Chen, AM Cypess Chronic mirabegron treatment increases human brown fat, HDL cholesterol, and insulin sensitivity J. Clin. Invest., 2020-05-01;0(0):. 2020-05-01 [PMID: 31961826] (Human)		Human
MJ Tang, JB Su, TL Xu, XQ Wang, DM Zhang, XH Wang Serum fibroblast growth factor 19 and endogenous islet beta cell function in type 2 diabetic patients Diabetol Metab Syndr, 2019-09-24;11(0):79. 2019-09-24 [PMID: 31572498] (Human)		Human
RN Appleby, I Moghul, S Khan, M Yee, P Manousou, TD Neal, JRF Walters Non-alcoholic fatty liver disease is associated with dysregulated bile acid synthesis and diarrhea: A prospective observational study PLoS ONE, 2019-01-25;14(1):e0211348. 2019-01-25 [PMID: 30682184] (Human)		Human
L Gao, L Lang, X Zhao, C Shay, AY Shull, Y Teng FGF19 amplification reveals an oncogenic dependency upon autocrine FGF19/FGFR4 signaling in head and neck squamous cell carcinoma Oncogene, 2018-12-05;0(0):. 2018-12-05 [PMID: 30518874] (Human)		Human
T Morville, RE Sahl, SA Trammell, JS Svenningse, MP Gillum, JW Helge, C Clemmensen Divergent effects of resistance and endurance exercise on plasma bile acids, FGF19, and FGF21 in humans JCI Insight, 2018-08-09;3(15):. 2018-08-09 [PMID: 30089729] (Human)		Human
G Cui, RC Martin, H Jin, X Liu, H Pandit, H Zhao, L Cai, P Zhang, W Li, Y Li Up-regulation of FGF15/19 signaling promotes hepatocellular carcinoma in the background of fatty liver J. Exp. Clin. Cancer Res., 2018-07-04;37(1):136. 2018-07-04 [PMID: 29973237] (Human)		Human
D Friedrich, HU Marschall, F Lammert Response of fibroblast growth factor 19 and bile acid synthesis after a body weight-adjusted oral fat tolerance test in overweight and obese NAFLD patients: a non-randomized controlled pilot trial BMC Gastroenterol, 2018-06-04;18(1):76. 2018-06-04 [PMID: 29866129] (Human)		Human
S Al-Dury, A Wahlström, S Wahlin, J Langedijk, RO Elferink, M Ståhlman, HU Marschall Pilot study with IBAT inhibitor A4250 for the treatment of cholestatic pruritus in primary biliary cholangitis Sci Rep, 2018-04-27;8(1):6658. 2018-04-27 [PMID: 29704003] (Human)		Human
JM Lee, JR Ong, L Vergnes, TQ de Aguiar, J Nolan, RM Cantor, JRF Walters, K Reue Diet1, bile acid diarrhea, and FGF15/19: mouse model and human genetic variants J. Lipid Res., 2018-01-02;0(0):. 2018-01-02 [PMID: 29295820] (Human)		Human
N Valentin, M Camilleri, P Carlson, SC Harrington, D Eckert, J O'Neill, D Burton, J Chen, AL Shaw, A Acosta Potential mechanisms of effects of serum-derived bovine immunoglobulin/protein isolate therapy in patients with diarrhea-predominant irritable bowel syndrome Physiol Rep, 2017-03-01;5(5):. 2017-03-01 [PMID: 28275113] (Human)		Human
S Straniero, F Rosqvist, D Edholm, H Ahlström, J Kullberg, M Sundbom, U Risérus, M Rudling Acute caloric restriction counteracts hepatic bile acid and cholesterol deficiency in morbid obesity J. Intern. Med, 2017-03-06;0(0):. 2017-03-06 [PMID: 28261926] (Human)		Human
L Martinez d, I Kyrou, J Vrbikova, V Hainer, P Sramkova, M Fried, MK Piya, S Kumar, G Tripathi, PG McTernan Impact of gut hormone FGF-19 on type-2 diabetes and mitochondrial recovery in a prospective study of obese diabetic women undergoing bariatric surgery BMC Med, 2017-02-16;15(1):34. 2017-02-16 [PMID: 28202005] (Human)		Human
Serum bile acids and GLP-1 decrease following telemetric induced weight loss: results of a randomized controlled trial Sci Rep, 2016-07-25;6(0):30173. 2016-07-25 [PMID: 27452603] (Human)		Human
Bile Acids and Dysbiosis in Non-Alcoholic Fatty Liver Disease PLoS ONE, 2016-05-20;11(5):e0151829. 2016-05-20 [PMID: 27203081] (Human)		Human
Natalia Gomez-Ospi, Carol J Potter, Rui Xiao, Kandamurugu Manickam, Mi-Sun Kim, Kang Ho Kim, Benjamin L Shneider, Jennifer L Picarsic, Theodora A Jacobson, Jing Zhang, Weimin He, Pengfei Liu, A S Knisely, Milton J Finegold, Donna M Muzny, Eric Boerwinkl, James R Lupski, Sharon E Plon, Richard A Gibbs, Christine M Eng, Yaping Yang, Gabriel C Washingto, Matthew H Porteus, William E Berquist, Neeraja Kambham, Ravinder J Singh, Fan Xia, Gregory M Enns, David D Moore Mutations in the nuclear bile acid receptor FXR cause progressive familial intrahepatic cholestasis. Nature Communications, 2016-02-18;0(0):2041-1723. 2016-02-18 [PMID: 26888176] (Human)		Human
Styer , Amanda M, Roesch , Stephen, Argyropoulos , George Modulation of fibroblast growth factor 19 expression by bile acids, meal replacement and energy drinks, milk, and coffee. PLoS ONE, 2014-01-20;9(1):e85558. 2014-01-20 [PMID: 24465600] (Human)		Human
Wang D, Zhu W, Li J, An C, Wang Z Serum concentrations of fibroblast growth factors 19 and 21 in women with gestational diabetes mellitus: association with insulin resistance, adiponectin, and polycystic ovary syndrome history. PLoS ONE, 2013-11-19;8(11):e81190. 2013-11-19 [PMID: 24260557] (Human)		Human
Feng S, Dakhova O, Creighton C, Ittmann M Endocrine fibroblast growth factor FGF19 promotes prostate cancer progression. Cancer Res, 2013-02-25;73(8):2551-62. 2013-02-25 [PMID: 23440425] (Human)		Human
Pournaras , Dimitri, Glicksman , Clare, Vincent , Royce P, Kuganolipava , Shophia, Alaghband-Zadeh , Jamie, Mahon , David, Bekker , Jan H R, Ghatei , Mohammad, Bloom , Stephen, Walters , Julian R, Welbourn , Richard, le Roux , Carel W The role of bile after Roux-en-Y gastric bypass in promoting weight loss and improving glycaemic control. Endocrinology, 2012-06-06;153(8):3613-9. 2012-06-06 [PMID: 22673227] (Human)		Human
Song KH, Li T, Owsley E Bile acids activate fibroblast growth factor 19 signaling in human hepatocytes to inhibit cholesterol 7alpha-hydroxylase gene expression. Hepatology, 2009-01-01;49(1):297-305. 2009-01-01 [PMID: 19085950] (Human)		Human
Show All 37 Publications. Collapse Publications.

Array DF1900

• FGF-19 Antibodies
• FGF-19 ELISA Kits
• FGF-19 Lysate
• FGF-19 Proteins
• FGF-19 ELISAs
• FGF-19 Proteins and Enzymes