FOLR2 Antibody

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Folate Receptor 2 (FOLR2), also known as Folate Receptor beta, is a 38 kDa protein that mediates the cellular uptake of folic acid and reduced folates. Dietary folates are required for many key metabolic processes including nucleotide and methionine synthesis, the interconversion of glycine and serine, and histidine breakdown (1, 2). Mature FOLR2 is an N-glycosylated protein that is anchored to the cell surface by a GPI linkage (3, 4). Human FOLR2 shares 83% amino acid sequence identity with mouse and rat FOLR2. FOLR2 is predominantly expressed in placenta, cells of the neutrophilic lineage, and some CD34+ hematopoietic progenitor cells (4‑6). It is upregulated on myeloid  leukemias, head and neck squamous cell carcinomas, and several nonepithelial cancers (3, 5, 7). It is also upregulated on macrophages and monocytes at chronic inflammatory sites including rheumatoid arthritis synovium and glioblastoma (8‑10). FOLR2 knockout mice do not show gross morphological defects, but they exhibit increased sensitivity to arsenate-induced teratogenicity (11, 12).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: Western Blot.

Showing Publications 1 - 4 of 4.

Publications using AF5697	Applications	Species
Omar M. Young, Zhonghua Tang, Tracy Niven-Fairchild, Serkalem Tadesse, Graciela Krikun, Errol R. Norwitz et al. Toll-like Receptor-Mediated Responses by Placental Hofbauer Cells (HBCs): A Potential Pro-Inflammatory Role for Fetal M2 Macrophages* American Journal of Reproductive Immunology 1/1/2015 [PMID: 25345551]
Puligujja P, McMillan J, Kendrick L et al. Macrophage Folate Receptor-Targeted Antiretroviral Therapy Facilitates Drug Entry, Retention, Antiretroviral Activities and Biodistribution for Reduction of Human Immunodeficiency Virus Infections. Nanomedicine 5/13/2013 [PMID: 23680933]
Zhonghua Tang, Irina A. Buhimschi, Catalin S. Buhimschi, Serkalem Tadesse, Errol Norwitz, Tracy Niven-Fairchild et al. DECREASED LEVELS OF FOLATE RECEPTOR-beta AND REDUCED NUMBERS OF FETAL MACROPHAGES (HOFBAUER CELLS) IN PLACENTAS FROM PREGNANCIES WITH SEVERE PREECLAMPSIA (PE)* American Journal of Reproductive Immunology 8/1/2013 [PMID: 23480364]
Tang Z, Niven-Fairchild T, Tadesse S, Norwitz E, Buhimschi C, Buhimschi I, Guller S Glucocorticoids enhance CD163 expression in placental Hofbauer cells. Endocrinology, 2012-11-09;154(1):471-82. 2012-11-09 [PMID: 23142809] (Western Blot, Human)	Western Blot	Human

Array AF5697

• FOLR2 Antibodies
• FOLR2 Lysates
• FOLR2 ELISA
• FOLR2 Proteins and Enzymes